Chapter 34. Biochemical Markers of Bone Turnover in Osteoporosis

Szulc, Paweł; Delmas, Pierre D.

doi:10.1002/9780470623992.ch34

Cited by 7 publications

(1 citation statement)

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“…Bone metabolism is the result of two opposite mechanisms involved in bone turn over. These include bone formation and resorption happening continuously as the tissue evolves [ 19 ]. Several markers of bone turnover each assessing specific physiolocal properties of this process have been introduced till now [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of calcitriol supplementation and tail suspension on serum biomarkers of bone formation in rats

Hashemian

Rismanchi

Esfahani

et al. 2015

J Diabetes Metab Disord

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BackgroundCalcitriol is documented to cause significant increase in bone mass densitometry counteracting osteoporosis. Promising results of calcitriol supplementation in studies aiming space flight induced osteoporosis is little and the effect of this hormone on biomarkers of bone metabolism is not examined yet in space flight models of osteoporosis in rats.MethodsThis was an interventional animal study being performed in a 1-month period. We included 21 Sprague Dawley strain rats (>200 gr, >6 week) who were randomly assigned to receive daily supplementation of oral 0.03μgr calcitriol and to be submitted to tail suspension model. Rats were followed for 1 month and were tested for serum osteocalcin (OC), alkaline phosphatase (ALP) and serum calcium at the beginning and the end of the study period. The results were analyzed and compared between groups.ResultsAlthough serum levels of osteocalcin and alkaline phosphatase biomarkers and total serum calcium were not significantly different within and between study groups, their levels were increased in tail suspension model compared to control group. The levels of these biomarkers were lower in those who were submitted to tail suspension model and received calcitriol supplementation compared to those who were only submitted to tail suspension (60.14 ± 11.73 ng/mL vs. 58.29 ± 2.69 ng/mL; p = 0.696 for osteocalcin and 381.86 ± 99.16 mU/mL vs. 362.57 ± 27.41 ng/mL; p = 0.635 for alkaline phosphatase).ConclusionSupplementation of daily diet with calcitriol in rats under weightlessness conditions may results in lower values for bone metabolic biomarkers of alkaline phosphatase and osteocalcin and serum calcium. This pattern of change in biomarkers of bone formation, may point to the capacity of calcitriol supplementation in preventing cellular process of osteoporosis. Thus calcitriol supplementation could be an available, economic and effective strategy for preventing bone metabolic changes related to weightlessness commonly encountered in space flight. The outcome of this study needs to be further studied in future trying to find more definite results.

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Section: Discussionmentioning

confidence: 99%