Chapter 4 Replication and Partitioning of Papillomavirus Genomes

McBride, Alison A.

doi:10.1016/s0065-3527(08)00404-1

Cited by 113 publications

(95 citation statements)

References 277 publications

(308 reference statements)

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“…1). In the viral life cycle, HPV replication is initiated by E2 binding and recruitment of the E1 helicase to the OR (McBride 2008). It also depends on activation of the DNA damage response by ATM (Gillespie et al 2012) and ATR (Reinson et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

et al. 2013

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Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of ''looping'' by which HPV integrant-mediated DNA replication and recombination may result in viral-host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability.

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Section: Discussionmentioning

confidence: 99%

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

et al. 2013

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“…DNA viruses are the smallest self-replicating entities, and specific palindromic sequences are required for their replication. 7,8 In most cases, the main initiating protein is encoded by the viral genome itself. Its binding to the Ori is also actively involved in the regulation of viral transcription and chromosomal segregation.…”

Section: New Insights Into Replication Origin Characteristics In Metamentioning

confidence: 99%

New insights into replication origin characteristics in metazoans

Cayrou¹,

Coulombe²,

Puy³

et al. 2012

Cell Cycle

168

143

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We recently reported the identification and characterization of DNA replication origins (Oris) in metazoan cell lines. Here, we describe additional bioinformatic analyses showing that the previously identified GC-rich sequence elements form origin G-rich repeated elements (OGREs) that are present in 67% to 90% of the DNA replication origins from Drosophila to human cells, respectively. Our analyses also show that initiation of DNA synthesis takes place precisely at 160 bp (Drosophila) and 280 bp (mouse) from the OGRE. We also found that in most CpG islands, an OGRE is positioned in opposite orientation on each of the two DNA strands and detected two sites of initiation of DNA synthesis upstream or downstream of each OGRE. Conversely, Oris not associated with CpG islands have a single initiation site. OGRE density along chromosomes correlated with previously published replication timing data. Ori sequences centered on the OGRE are also predicted to have high intrinsic nucleosome occupancy. Finally, OGREs predict G-quadruplex structures at Oris that might be structural elements controlling the choice or activation of replication origins.

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“…[63,65,66] One of the hypotheses suggests that E2 may be possibly involved in genome partitioning where the viral transcription is regulated by E2. [67] A viral DNA helicase, such as E1, may separate the viral DNA replication from cellular DNA replication during establishment and amplification of the genome. [6,68] Of all the HPV proteins, E6 and E7 are the key ones associated in cancers via eliminating the tumour suppressors p53 and Rb leading to anti-apoptosis, genetic instability and formation of skin or mucosa lesions.…”

Section: Role Of Hpv In Cancer Developmentmentioning

confidence: 99%

The role of human papillomaviruses in cancer progression

Tulay¹,

Serakıncı²

2016

JCMT

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The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken. In the last decade, development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers. In this report, we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

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Chapter 4 Replication and Partitioning of Papillomavirus Genomes

Cited by 113 publications

References 277 publications

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

New insights into replication origin characteristics in metazoans

The role of human papillomaviruses in cancer progression

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