Chapter 5.4 Memory and cognitive performance in preclinical Alzheimer's disease and preclinical vascular disease

Small, Brent J.; MacDonald, Stuart W. S.; Iser, Lindsay; Bäckman, Lars

doi:10.1016/s1569-7339(08)00229-4

Cited by 2 publications

(5 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is because the distributions between the two groups still overlap to a large extent (>40%) for individual cognitive domains such as episodic memory or executive functioning. To increase sensitivity of early detection, Small et al suggest that future research incorporates the following improvements 145. First, these authors emphasize that multifactorial prediction models are required to improve early detection.…”

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

“…In particular, including multiple measurement occasions before diagnosis is required to better identify the onset of cognitive decline during the prodromal period, as well as to quantify the magnitude of acceleration. Multiwave datasets and linear mixed models may also identify whether select dementia correlates increase or decrease in importance in proximity to diagnosis 145. Such differentiation may help differentiate between disease risk factors vs precipitating factors.…”

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

“…Considerable effort has been devoted to better understanding change in cognitive functioning during the prodromal phase of dementia. 145 This research focus is well intentioned given the protracted nature of neuropathological change in dementia, coupled with the fact that effective treatment pharmacotherapy remains elusive. 146 Ultimately, the success of potential interventions will be further augmented through the early detection of those at risk.…”

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

“…To increase sensitivity of early detection, Small et al suggest that future research incorporates the following improvements. 145 First, these authors emphasize that multifactorial prediction models are required to improve early detection. Evidence suggests that early detection is improved considerably upon inclusion not only of episodic memory tasks, but also indicators of executive functioning and semantic memory.…”

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

“…Multiwave datasets and linear mixed models may also identify whether select dementia correlates increase or decrease in importance in proximity to diagnosis. 145 Such differentiation may help differentiate between disease risk factors vs precipitating factors.…”

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

See 4 more Smart Citations

Clinical features and multidisciplinary approaches to dementia care

Grand¹,

Caspar²,

MacDonald³

2011

JMDH

112

View full text Add to dashboard Cite

Dementia is a clinical syndrome of widespread progressive deterioration of cognitive abilities and normal daily functioning. These cognitive and behavioral impairments pose considerable challenges to individuals with dementia, along with their family members and caregivers. Four primary dementia classifications have been defined according to clinical and research criteria: 1) Alzheimer’s disease; 2) vascular dementias; 3) frontotemporal dementias; and 4) dementia with Lewy bodies/Parkinson’s disease dementia. The cumulative efforts of multidisciplinary healthcare teams have advanced our understanding of dementia beyond basic descriptions, towards a more complete elucidation of risk factors, clinical symptoms, and neuropathological correlates. The characterization of disease subtypes has facilitated targeted management strategies, advanced treatments, and symptomatic care for individuals affected by dementia. This review briefly summarizes the current state of knowledge and directions of dementia research and clinical practice. We provide a description of the risk factors, clinical presentation, and differential diagnosis of dementia. A summary of multidisciplinary team approaches to dementia care is outlined, including management strategies for the treatment of cognitive impairments, functional deficits, and behavioral and psychological symptoms of dementia. The needs of individuals with dementia are extensive, often requiring care beyond traditional bounds of medical practice, including pharmacologic and non-pharmacologic management interventions. Finally, advanced research on the early prodromal phase of dementia is reviewed, with a focus on change-point models, trajectories of cognitive change, and threshold models of pathological burden. Future research goals are outlined, with a call to action for social policy initiatives that promote preventive lifestyle behaviors, and healthcare programs that will support the growing number of individuals affected by dementia.

show abstract

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

Section: Empirical Research On Dementia: Toward Facilitating Early Dementioning

confidence: 99%

See 3 more Smart Citations

Clinical features and multidisciplinary approaches to dementia care

Grand¹,

Caspar²,

MacDonald³

2011

JMDH

112

View full text Add to dashboard Cite

show abstract

Placing behaviour at the forefront of brain science

Cirulli

Easton

2022

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Chapter 5.4 Memory and cognitive performance in preclinical Alzheimer's disease and preclinical vascular disease

Cited by 2 publications

References 81 publications

Clinical features and multidisciplinary approaches to dementia care

Clinical features and multidisciplinary approaches to dementia care

Placing behaviour at the forefront of brain science

Contact Info

Product

Resources

About