CHAPTER 5. Activation of Chemical Substrates Under Sustainable Conditions: Electrochemistry and Electrocatalysis

Continuous Kolbe Electrolysis Using an Electrochemical Microreactor, Product Separation, and Electrolyte Recycling

“…Electrochemistry as alternative synthesis method is currently experiencing growing interest as it has a huge potential to pave the way towards greener and more sustainable synthesis routes [1][2][3][4]. For instance, the direct use of electrical current allows the substitution of environmental critical oxidating or reducing agents which are very often used in equimolar ratio.…”

Electrochemically Enabled Total Syntheses of Natural Products

“…Electrochemical methodology and the community of researchers involved in this exciting area of chemistry expands on a daily basis. Investigators such as Opatz and Waldvogel, [13][14][15][16][17][18]…”

“…Electrochemical methodology and the community of researchers involved in this exciting area of chemistry expands on a daily basis. Investigators such as Opatz and Waldvogel, [13–18] Baran, [19–28] Shono, [29,124,125,138,140,224] Moeller, [77,79,108,143] Little, [30–44] Lin, [45–54] and Stahl [55–62] are just a few of the researchers that have been integral to growing the available electrochemical toolset, educating the broader synthesis community, and drawing these techniques into mainstream organic synthesis. Electrochemical toolsets have been extensively reviewed in various contexts including comprehensive monographs; [5–17] this brief review highlights the use of electrochemical bond formations in the arena of natural products total synthesis with particular focus on completed works.…”

“…Investigators such as Opatz and Waldvogel, [13–18] Baran, [19–28] Shono, [29,124,125,138,140,224] Moeller, [77,79,108,143] Little, [30–44] Lin, [45–54] and Stahl [55–62] are just a few of the researchers that have been integral to growing the available electrochemical toolset, educating the broader synthesis community, and drawing these techniques into mainstream organic synthesis. Electrochemical toolsets have been extensively reviewed in various contexts including comprehensive monographs; [5–17] this brief review highlights the use of electrochemical bond formations in the arena of natural products total synthesis with particular focus on completed works. Where possible, we have endeavored to present works chronologically within different classes of natural products but for the sake of clarity, some achievements and strategies are presented by reaction type.…”