2009
DOI: 10.1016/s1043-4526(09)58006-0
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Chapter 6 Gossypol-A Polyphenolic Compound from Cotton Plant

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Cited by 114 publications
(86 citation statements)
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“…Extracts from the bark of the tree Ulmus laevis have been shown to inhibit endometrial carcinoma [14], berberine and rhizoma coptidis represent novel antineoplastic agents [15], gossypol from the cotton plant (genus Gossypium) has an anticancer action [16], and annonaceous acetogenins from the seeds Annona plants have exhibited cytotoxic, antitumoral and immunosuppressive activities [17]. Both, duocarmycins and yatakemycin may lead to the development of other natural products [18]; an extract of the fruit from Xylopia aethiopica demonstrated an antiproliferative action on human cervical cancer cells [19], while extracts of the leaves of Brysocarpus coccineus have suggested their potential use in cancer chemotherapy [20].…”
Section: Anticancer Drugsmentioning
confidence: 99%
“…Extracts from the bark of the tree Ulmus laevis have been shown to inhibit endometrial carcinoma [14], berberine and rhizoma coptidis represent novel antineoplastic agents [15], gossypol from the cotton plant (genus Gossypium) has an anticancer action [16], and annonaceous acetogenins from the seeds Annona plants have exhibited cytotoxic, antitumoral and immunosuppressive activities [17]. Both, duocarmycins and yatakemycin may lead to the development of other natural products [18]; an extract of the fruit from Xylopia aethiopica demonstrated an antiproliferative action on human cervical cancer cells [19], while extracts of the leaves of Brysocarpus coccineus have suggested their potential use in cancer chemotherapy [20].…”
Section: Anticancer Drugsmentioning
confidence: 99%
“…It acts as a contraceptive by inhibiting enzyme systems that effect energy metabolism in sperm and spermatogenic cells (Coutinho, 2002;Wang et al, 2009).…”
Section: Antifertility/contraceptivementioning
confidence: 99%
“…Its free toxic form presents great concern in cottonseed and cottonseed meal commonly used as protein supplement for cattle. 36 Especially toxic for monogastric animals 37 and young calves, 38 adult ruminants are more resistant due to protein complex formation within the rumen. 39 Exceeding a dose of 24 g of free gossypol per day can lead to toxicosis because of inability of the animal to detoxify more than this amount.…”
Section: Toxic Plantsmentioning
confidence: 99%