Chapter 6. Memory and Learning

Anderson, Paul S.; Haubrich, Dean R.

doi:10.1016/s0065-7743(08)61273-7

Cited by 7 publications

(3 citation statements)

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“…There is evidence both from animal and human studies indicating that learning and memory can be modified by drugs which affect central cholinergic functions (McGaugh 1973;Drachman 1977;Anderson and Haubrich 1981). For instance, scopolamine, a muscarinic receptor blocking drug, has been shown to impair memory (Safer and Allen 1971;Frumier et al 1976) whereas muscarinic agonists, such as oxotremorine or arecoline, and acetylcholinesterase inhibitots, such as physostimnine, facilitate cognitive processes in animals and humans (Baratti et al 1979;Christie et al 1981;Mohs et al 1985).…”

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Effects of nootropic drugs in a scopolamine-induced amnesia model in mice

et al. 1988

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Scopolamine (3 mg/kg IP) given before an acquisition trial, reduced the retention of a one-trial passive avoidance "step through" response in mice. A single administration of cholinergic agonists such as oxotremorine, BM-5, or arecoline, antagonized this amnesic effect of scopolamine. A significant anti-amnesic effect was also found with nootropic drugs such as piracetam and ucb L059, whereas ucb L060 (the enantiomer of ucb L059), oxiracetam and rolziracetam were shown to be ineffective. Moreover, ucb L059, administered twice daily for 3 days, counteracted the amnesic effects of scopolamine completely, whereas ucb L060 was again inactive. The results demonstrate that: (a) this model of impaired cognition by scopolamine is able to discriminate between closely related chemical substances and even stereoisomers; and (b) nootropic drugs, such as ucb L059, are more effective after repeated rather than after acute administration.

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Effects of nootropic drugs in a scopolamine-induced amnesia model in mice

et al. 1988

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“…peaking a foreign language is a cognitive skill that involves many complex sub-processes for its execution. As with other skills, most of these subprocesses take place without our awareness and/or control and must be automatized so as to free mental capacity to execute other processes and subprocesses (ANDERSON, 1995).…”

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Working memory capacity and L2 speech production in a picture description task with repetition

Finardi¹

2008

Rev. Est. Ling.

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This study investigates the relationship between working memory capacity and gains in L2 oral performance in a picture description task with repetition. It departs from Fortkamp (2000) who found significant correlations between working memory capacity and measures of L2 speech performance and Bygate´s (2001b) findings that when repeating an oral task participants gained in complexity of L2 speech at the expense of accuracy and fluency, to propose that there might be a correlation between gains in complexity of L2 speech and working memory capacity. Results show there are gains in complexity of L2 speech in the second trial of the same task, but these gains do not correlate with working memory capacity. The lack of correlations is explained by the small number of participants, which did not allow for variation in terms of working memory capacity.

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“…Reaction of the dioxolane with the ribofuranuronic acid 10 via the acid azide prepared in situ by means of diphenylphosphoryl azide was poor; the yields ranged between 20 and 35%. Hydrolysis of the dioxolane 11 with dilute acid gave the desired / (12). Although preliminary results indicated that the bromo compound 13 can be made in a similar manner, 13 and 14 were readily prepared by the halide exchange reaction described above for 8 and 9.…”

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