Chapter 6 Neuroendocrine states and behavioral and physiological stress responses

Bohus, B.; Benus, R.F.; Fokkema, Dirk S.; Koolhaas, Jaap M.; Nyakas, Csaba; Oortmerssen, G.A. van; Prins, A.J.A.; Ruiter, A.J.H. de; Scheurink, Antonius; Steffens, A.B.

doi:10.1016/s0079-6123(08)60196-x

Cited by 171 publications

(91 citation statements)

References 45 publications

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“…However, some of the applied stress paradigms, such as ether and hypoglycemia, did not affect the secretion of either of the two hormones. The stress response is probably an interaction between the neuroendocrine system, the sympathetic nervous system and the target organs, resulting in activation of different neuronal pathways and release of specific hormones (35). Stress in itself releases various neurotransmitters, which may have either stimulating (catecholamines, 5-HT, histamine) or inhibiting (GABA) effect on hypothalamic and pituitary hormone release (19).…”

Section: Discussionmentioning

confidence: 99%

Serotonergic involvement in stress-induced vasopressin and oxytocin secretion

Jørgensen

Knigge²,

Kjær³

et al. 2002

European Journal of Endocrinology

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Objective: To investigate the involvement of serotonin (5-hydroxytryptamine -5-HT) receptors in mediation of stress-induced arginine vasopressin (AVP) and oxytocin (OT) secretion in male rats. Design: Experiments on laboratory rats with control groups. Methods: Different stress paradigms were applied after pretreatment with intracerebroventricular infusion of saline or different 5-HT antagonists. Results: Restraint stress (5 min), hypotensive hemorrhage or dehydration for 24 h increased AVP secretion fivefold and OT secretion threefold. Swim stress for 3 min had no effect on AVP secretion, but increased OT secretion threefold. Ether vapor or hypoglycemia had no effect on AVP or OT secretion. The restraint stress-induced AVP response was inhibited by pretreatment with the 5-HT 2Aþ2C antagonists ketanserin (KET) and LY-53857 (LY) and the 5-HT 3þ4 antagonist ICS-205930 (ICS), whereas the 5-HT 1A antagonist WAY-100635 (WAY) had no effect. The OT response to restraint stress was inhibited by WAY, KET and LY but not by ICS. KET and LY inhibited OT response to dehydration, and LY inhibited OT response to hemorrhage. Neither of the antagonists affected AVP responses to dehydration or hemorrhage, nor the swim stress-induced OT response.

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Section: Discussionmentioning

confidence: 99%

Serotonergic involvement in stress-induced vasopressin and oxytocin secretion

Jørgensen

Knigge²,

Kjær³

et al. 2002

European Journal of Endocrinology

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“…Various behavioural studies that have included neuroendocrine parameters have shown that at least two distinct stress response patterns, referred to as proactive and reactive stress coping styles, exist in mammals (Bohus, et al, 1987;Koolhaas et al, 1999;. The proactive and reactive stress coping style is characterized by behavior patterns that are similar to those described for bold and shy individuals, and these traits are associated with a defined set of neuroendocrine characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…Primarily, when exposed to a stressor the proactive individuals display a sympathetic activation (the fight/flight response), while reactive individuals respond with a parasympathetic/hypothalamic activation (the conservation/withdrawal response) (Bohus et al, 1987;Koolhaas et al, 1999). Consequently, the reactive individuals respond to stressors with greater hypothalamic-pituitary-adrenocortical (HPA) axis reactivity, resulting in a larger increase in plasma glucocorticoid levels compared to proactive animals (Koolhaas et al, 1999;.…”

Section: Introductionmentioning

confidence: 99%

Divergence in behavioural responses to stress in two strains of rainbow trout () with contrasting stress responsiveness

Schjolden

Bäckström²,

Pulman³

et al. 2005

Hormones and Behavior

115

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The aim of this study was to establish whether two lines of rainbow trout divergent for their plasma cortisol response to a standardized stressor would show consistent differences in their behavioural response to a range of challenging situations. Our results show that the high-and low-responding (HR and LR) lines of rainbow trout did not differ in the aggression shown towards an intruder or in their response to the introduction of a novel object to their home environment. However, there was a difference in behaviour between the two selection lines when they were exposed to two unfamiliar environments. These results suggest that the behaviour of the HR and LR fish differs when they are challenged in unfamiliar environments, while their behaviour does not differ when they are challenged in their home environment. These observations are in agreement with studies on mammals thatshow that individuals with reactive coping styles perform similarly to proactive animals when they are challenged in a familiar environment, while they show different behaviour when they are challenged in unfamiliar environments. Thus, these results provide further evidence that the HR and LR selection lines of rainbow trout exemplify the two different coping styles described in mammals.

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“…Immobility behavior Autonomic responses Bradycardia Stress Amphetamine Vasopressin IN aging animals and humans, stress-related cardiac dysrhythmias and hypertension may involve autonomic dysfunctions (1,18,23,24). Previous research in this laboratory was focussed on the age-related changes in the autonomic responses due to stressors inducing behavioral immobility.…”

Section: Agingmentioning

confidence: 99%