Chapter 7 Inflammatory Optic Neuropathies Not Associated with Multiple Sclerosis

Kidd, Desmond P.

doi:10.1016/s1877-184x(09)70037-1

Cited by 8 publications

(10 citation statements)

References 162 publications

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“…Colour vision is frequently impaired and, like IDON, there are many possible different patterns of visual field loss. Over 50% have optic disc pallor at presentation, but several other abnormalities are common including disc swelling, periphlebitis and granuloma; only 10% have truly normal fundi 29 31 32…”

Section: Mimicsmentioning

confidence: 99%

“…Relapses are usually corticosteroid-sensitive, but they continue to recur so patients end up on low-dose maintenance therapy 33. The final visual acuity is, overall, worse than that of IDON, and there is a strong suggestion that earlier, more aggressive treatment with corticosteroids gives a better outcome 32 34…”

Section: Mimicsmentioning

confidence: 99%

“…Visual loss is predominantly due to maculopathy rather than optic nerve dysfunction. Neuroretinitis is classified into three broad categories: (1) idiopathic, (2) associated with infection (most commonly cat-scratch fever due to Bartonella henselae but there are reports of many other causative organisms32), and (3) inflammatory but non-infectious (eg, sarcoidosis or polyarteritis nodosa) 44…”

Section: Mimicsmentioning

confidence: 99%

“…Nevertheless, the conditions have the potential to cause apparently isolated involvement of the optic nerve(s) which could result in diagnostic difficulty. The list has been compiled from a number of published sources 3 32 67 68. Highlighted items in dark red are discussed in detail in the text.…”

Section: Introductionmentioning

confidence: 99%

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Mimics and chameleons of optic neuritis

Weerasinghe

Lueck

2016

Pract Neurol

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Optic neuritis is a common problem and most neurologists are familiar with it. Recent studies have suggested that it can be overdiagnosed in as many as 10% of cases. The major reasons for this relate to confusion regarding terminology and lack of familiarity with common mimics. This article covers typical 'idiopathic' demyelinating optic neuropathy (IDON) and several possible variations in the way it can present (chameleons). We then discuss several conditions that can mimic IDON, including neuromyelitis optica, sarcoidosis, chronic relapsing inflammatory optic neuropathy, anterior ischaemic optic neuropathy, infectious/parainfectious optic neuropathy, neuroretinitis, Leber's hereditary optic neuropathy, and some 'ocular' mimics including autoimmune retinopathy and central serous choroidoretinopathy.

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Section: Mimicsmentioning

confidence: 99%

Section: Mimicsmentioning

confidence: 99%

Section: Mimicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mimics and chameleons of optic neuritis

Weerasinghe

Lueck

2016

Pract Neurol

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“…The primary objective of the trial was the assessment of the efficacy of corticosteroids in the treatment of optic neuritis. It also gives some information about the clinical profile of optic neuritis, its natural history and its relationship to MS 3 . Inclusion criteria in ONTT included a clinical syndrome consistent with unilateral optic neuritis (including a relative afferent pupillary defect and a visual field defect in the affected eye), visual symptoms of eight days or less, no previous episodes of optic neuritis in the affected eye, no previous corticosteroid treatment for optic neuritis or MS, and no evidence of a systemic disease other than MS as a cause for the optic neuritis 4 .…”

Section: Optic Neuritis Treatment Trial (Ontt)mentioning

confidence: 99%

Role Of Various Factors In The Treatment Of Optic Neuritis----A Study

Prasad¹,

Ravikiran²

2016

IOSR

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Optic neuropathy associated with systemic sarcoidosis

Kidd

Burton

Graham

et al. 2016

Neurol Neuroimmunol Neuroinflamm

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Objective:To identify and follow a series of 52 patients with optic neuropathy related to sarcoidosis.Methods:Prospective observational cohort study.Results:The disorder was more common in women and affected a wide age range. It was proportionately more common in African and Caribbean ethnic groups. Two clinical subtypes were identified: the more common was a subacute optic neuropathy resembling optic neuritis; a more slowly progressive optic neuropathy arose in the remaining 17%. Sixteen (31%) were bilateral. Concurrent intraocular inflammation was seen in 36%. Pain arose in only 27% of cases. An optic perineuritis was seen in 2 cases, and predominate involvement of the chiasm in one. MRI findings showed optic nerve involvement in 75% of cases, with adjacent and more widespread inflammation in 31%. Treatment with corticosteroids was helpful in those with an inflammatory optic neuropathy, but not those with mass lesions. Relapse of visual signs arose in 25% of cases, necessitating an increase or escalation of treatment, but relapse was not a poor prognostic factor.Conclusions:This is a large prospective study of the clinical characteristics and outcome of treatment in optic neuropathy associated with sarcoidosis. Patients who experience an inflammatory optic neuropathy respond to treatment but may relapse. Those with infiltrative or progressive optic neuropathies improve less well even though the inflammatory disorder responds to therapy.

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Chapter 7 Inflammatory Optic Neuropathies Not Associated with Multiple Sclerosis

Cited by 8 publications

References 162 publications

Mimics and chameleons of optic neuritis

Mimics and chameleons of optic neuritis

Role Of Various Factors In The Treatment Of Optic Neuritis----A Study

Optic neuropathy associated with systemic sarcoidosis

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