CHAPTER iv: BLOOD, PLASMA AND RED‐CELL VOLUMES IN PATIENTS WITH RHEUMATOID ARTHRITIS OR IRON DEFICIENCY AND IN CONTROLS

The activities in blood of six enzymes of the haem biosynthetic pathway have been determined in 12 patients with rheumatoid disease, six of whom were anaemic. The porphyrin and porphyrin-precursor intermediary products of haem biosynthesis were also determined in blood, urine and faeces. No significant differences were found between anaemic and non-anaemic subjects. Failure of delta-amino-laevulinate synthase activity to increase in response to anaemia may be the nature of the marrow unresponsiveness suggested as one factor in the causation of the anaemia. Normal ferrochelatase activity and normal concentrations of free protoporphyrin support the view that iron is effectively unavailable although present in normal amounts. Coproporphyrinogen oxidase activity was significantly depressed.

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CHAPTER iv: BLOOD, PLASMA AND RED‐CELL VOLUMES IN PATIENTS WITH RHEUMATOID ARTHRITIS OR IRON DEFICIENCY AND IN CONTROLS

Cited by 3 publications

References 21 publications

Hematologic abnormalities in rheumatoid arthritis

Hematologic abnormalities in rheumatoid arthritis

Extraarticular manifestations of rheumatoid arthritis

Haem Biosynthesis in Rheumatoid Disease

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