Character comparison of abdomen‐derived and eyelid‐derived mesenchymal stem cells

Kim, S.‐H.; Bang, So Hee; Park, S. A.; Kang, So Yeong; Park, K. D.; Oh, Il Ung; Yoo, Si Hyung; Kim, H.; Kim, C.‐H.; Lee, Ji Hyun

doi:10.1111/cpr.12027

Cited by 11 publications

(14 citation statements)

References 34 publications

(32 reference statements)

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“…MSCs were first characterized from bone marrow, adipose and embryonic tissues and are well-documented to travel to tumor sites [ 8 - 10 ]. MSCs have now been reported in a variety of other tissues including ovary, brain, spleen, liver, kidney, lung, muscle, thymus, pancreas, eyelid, and the peri-vasculature [ 11 - 13 ], suggesting MSCs may be present in many tissues throughout tumor initiation and growth.…”

Section: Introductionmentioning

confidence: 99%

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistanceviaa BMP4/HH signaling loop

et al. 2016

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The tumor microenvironment is critical to cancer growth and therapy resistance. We previously characterized human ovarian carcinoma-associated mesenchymal stem cells (CA-MSCs). CA-MSCs are multi-potent cells that can differentiate into tumor microenvironment components including fibroblasts, myofibroblasts and adipocytes. We previously reported CA-MSCs, compared to normal MSCs, express high levels of BMP proteins and promote tumor growth by increasing numbers of cancer stem-like cells (CSCs). We demonstrate here that ovarian tumor cell-secreted Hedgehog (HH) induces CA-MSC BMP4 expression. CA-MSC-derived BMP4 reciprocally increases ovarian tumor cell HH expression indicating a positive feedback loop. Interruption of this loop with a HH pathway inhibitor or BMP4 blocking antibody decreases CA-MSC-derived BMP4 and tumor-derived HH preventing enrichment of CSCs and reversing chemotherapy resistance. The impact of HH inhibition was only seen in CA-MSC-containing tumors, indicating the importance of a humanized stroma. These results are reciprocal to findings in pancreatic and bladder cancer, suggesting HH signaling effects are tumor tissue specific warranting careful investigation in each tumor type. Collectively, we define a critical positive feedback loop between CA-MSC-derived BMP4 and ovarian tumor cell-secreted HH and present evidence for the further investigation of HH as a clinical target in ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistanceviaa BMP4/HH signaling loop

et al. 2016

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“…35 ). Evenmore, it has been shown that adipose derived MSCs possess different abilities according to the tissue of origin 38,39 . Comparison of MSCs from abdominal fat, mesodermal origin, eyelid adipose tissue MSCs, and ectodermal origin, showed different phenotypes of cells together with variety in CD90 expression, suggesting higher abdominal fat MSCs response to angiogeneic factors 38 .…”

Section: Mscs Source Variabilitymentioning

confidence: 99%

“…Evenmore, it has been shown that adipose derived MSCs possess different abilities according to the tissue of origin 38,39 . Comparison of MSCs from abdominal fat, mesodermal origin, eyelid adipose tissue MSCs, and ectodermal origin, showed different phenotypes of cells together with variety in CD90 expression, suggesting higher abdominal fat MSCs response to angiogeneic factors 38 . Comparison of cardiac adipose tissue derived MSCs and abdominal fat MSCs, both of mesodermal origin, showed that cells were phenotypically identical, but cardiac MSCs constituted intristic properties toward myogenesis and vasculogenesis in significantly higher percentage and therefore have much better regenerative potential, especially for cardiac therapy 39 .…”

Section: Mscs Source Variabilitymentioning

confidence: 99%

Mesenchymal stem cells as the near future of cardiology medicine - truth or wish?

Brychtová

Thiele

Lysák

et al. 2019

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Cardiac damage is one of major cause of worldwide morbidity and mortality. Despite the development in pharmacotherapy, cardiosurgery and interventional cardiology, many patients remain at increased risk of developing adverse cardiac remodeling. An alternative treatment approach is the application of stem cells. Mesenchymal stem cells are among the most promising cell types usable for cardiac regeneration. Their homing to the damaged area, differentiation into cardiomyocytes, paracrine and/or immunomodulatory effect on cardiac tissue was investigated extensively. Despite promising preclinical reports, clinical trials on human patients are not convincing. Meta-analyses of these trials open many questions and show that routine clinical application of mesenchymal stem cells as a cardiac treatment may be not as helpful as expected. This review summarizes contemporary knowledge about mesenchymal stem cells role in cardiac tissue repair and discusses the problems and perspectives of this experimental therapeutical approach.

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“…Human eyelid adipose-derived stem cells (HEASCs) are novel MSCs and originated from the neural crest source. In addition, HEASCs are also similar to BMSCs in the growth potential and surface marker expression [ 7 , 9 ]. In addition, HEASCs lacked immunogenicity and were safe and well-tolerated after intravenous injections and topical administration in previous studies [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Age on the Regenerative Potential of Human Eyelid Adipose-Derived Stem Cells

Zhang

Wang

Zhao

et al. 2018

Stem Cells International

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Human eyelid adipose-derived stem cells (HEASCs) are a new source of autologous mesenchymal stem cells, which are derived from neuroectoderm and potentially applied in the tissue regeneration and cell therapies. Based on the prevalence of blepharoplasty in Asia and the availability of HEASCs, we investigated the effect of donor age on their characteristics and regenerative potential of HEASCs in vitro. The HEASCs were isolated from patients of three groups: (1) <20 years (n = 4), (2) >20 years, <45 years (n = 5), and (3) >55 years (n = 4). For each group, the proliferative capacity, colony-forming ability, surface markers, differentiation ability, wound healing function, and secreted protein were contrastively evaluated and quantified for statistical analysis. It was found that HEASCs were successfully isolated and cultured by an explant culture method. The proliferative rates, osteogenic and chondrogenic differentiation potentials, wound healing ability, and the expression of TGF-β1 and fibronectin protein of HEASCs significantly decreased as age increased. However, the expression of CD90 antigen and the adipogenic differentiation showed an age-related increase in HEASCs. As many degenerative diseases increase in prevalence with age, the age-related changes of the HEASCs proliferation potential, differentiation capacity, and wound healing ability should be taken into account whenever they are intended for use in research or cytotherapy.

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Character comparison of abdomen‐derived and eyelid‐derived mesenchymal stem cells

Abstract: Although isolated from similar adipose tissues, both types of cells displayed many contrasting characteristics. Understanding defining phenotypes of such cells is useful for making suitable choices in differing clinical indications.

Cited by 11 publications

References 34 publications

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistanceviaa BMP4/HH signaling loop

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistanceviaa BMP4/HH signaling loop

Mesenchymal stem cells as the near future of cardiology medicine - truth or wish?

The Effect of Age on the Regenerative Potential of Human Eyelid Adipose-Derived Stem Cells

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