Characterisation and cellular uptake of polysorbate 80-coated PLA nanoparticles

Raudszus, Bastian; Partikel, Katrin; Mulac, Dennis; Langer, Klaus

doi:10.1016/j.matpr.2017.09.186

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…This result seems to be in accordance with the suggestion from Kreuter et al that the core of the nanoparticles could influence the surface properties of the nanoparticles and therefore their ability to bind with apolipoproteins in the blood [54]. PS80 coating was also successful for PLA-b-PEG nanoparticles [58] but failed for PLA nanoparticles [59]. PLGA-PEG-PLGA nanoparticles loaded with loperamide and coated with either PS80 or P188 were compared [60].…”

Section: Coating With Surfactantssupporting

confidence: 88%

Key for crossing the BBB with nanoparticles: the rational design

Lombardo

Schneider

Türeli³

et al. 2020

Beilstein J. Nanotechnol.

163

106

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Central nervous system diseases are a heavy burden on society and health care systems. Hence, the delivery of drugs to the brain has gained more and more interest. The brain is protected by the blood–brain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessels, which at the same time acts as a bottleneck for drug delivery by preventing the vast majority of drugs to reach the brain. To overcome this obstacle, drugs can be loaded inside nanoparticles that can carry the drug through the BBB. However, not all particles are able to cross the BBB and a multitude of factors needs to be taken into account when developing a carrier system for this purpose. Depending on the chosen pathway to cross the BBB, nanoparticle material, size and surface properties such as functionalization and charge should be tailored to fit the specific route of BBB crossing.

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Section: Coating With Surfactantssupporting

confidence: 88%

Key for crossing the BBB with nanoparticles: the rational design

Lombardo

Schneider

Türeli³

et al. 2020

Beilstein J. Nanotechnol.

163

106

View full text Add to dashboard Cite

show abstract

“…Since then, polylactide‐ co ‐glycolide (PLGA) NPs loaded with either loperamide or doxorubicin and coated with PS80 or P188 have demonstrated an ability to cross the BBB and deliver their cargo to the brain (Gelperina et al, 2010). PS80 coating was also successful for PLA (polylactic acid)‐ b ‐PEG NPs (Ren et al, 2009) but was unsuccessful for PLA NPs (Raudszus et al, 2017). This suggests that effectiveness of the coating is influenced by the composition of the NP core and the components used in its development (Kreuter, 2004).…”

Section: Bbb Dysfunction In Dementiamentioning

confidence: 99%

Blood–brain barrier disruption in dementia: Nano‐solutions as new treatment options

Cooper,

Kafetzis,

Patabendige

et al. 2023

Eur J of Neuroscience

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Candidate drugs targeting the central nervous system (CNS) demonstrate extremely low clinical success rates, with more than 98% of potential treatments being discontinued due to poor blood–brain barrier (BBB) permeability. Neurological conditions were shown to be the second leading cause of death globally in 2016, with the number of people currently affected by neurological disorders increasing rapidly. This increasing trend, along with an inability to develop BBB permeating drugs, is presenting a major hurdle in the treatment of CNS‐related disorders, like dementia. To overcome this, it is necessary to understand the structure and function of the BBB, including the transport of molecules across its interface in both healthy and pathological conditions. The use of CNS drug carriers is rapidly gaining popularity in CNS research due to their ability to target BBB transport systems. Further research and development of drug delivery vehicles could provide essential information that can be used to develop novel treatments for neurological conditions. This review discusses the BBB and its transport systems and evaluates the potential of using nanoparticle‐based delivery systems as drug carriers for CNS disease with a focus on dementia.

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Characterisation and cellular uptake of polysorbate 80-coated PLA nanoparticles

Cited by 2 publications

References 16 publications

Key for crossing the BBB with nanoparticles: the rational design

Key for crossing the BBB with nanoparticles: the rational design

Blood–brain barrier disruption in dementia: Nano‐solutions as new treatment options

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