Characterisation by PIXE–RBS of metallic contamination of tissues surrounding a metallic prosthesis on a knee

Guibert, G.; Irigaray, J.L.; Moretto, Ph.; Sauvage, Thierry; Kémény, Jean-Louis; Cazenave, A.; Jallot, Édouard

doi:10.1016/j.nimb.2006.06.032

Cited by 15 publications

(7 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this case study, the next biomaterials selected are Stainless Steel, Titanium Alloys (Ti), Cobalt-Cromium Alloys (Co-Cr), Polylactic Acid (PLA) and Polyetherether ketone (PEEK). The biomechanical characterization and biocompatibility, was previously examined by Guibert et al [8] and Marti [9]. In addition, CoCr rods demonstrated significantly larger fatigue lifespan compared to Ti rods during cyclic loading testing [10].…”

Section: Fig 2: Type Of Spinal Surgery Option [4]mentioning

confidence: 98%

Biomechanical Analysis of Spinal Fusion Cage for Lumbar Vertebrae

Yahya¹,

Mazlan²,

Shuib³

et al. 2019

IJRTE

View full text Add to dashboard Cite

Lumbar spinal fusion or lumbar interbody fusion is a surgical procedure done by putting the cages implant between the lumbar vertebra supported by rods and screws to hold the vertebra. This procedure is commonly used to treat disc degeneration diseases and other medical conditions. However, failure of the subcutaneous vertebral endplate has been identified to increase the possibility of biomechanical instability. There are broad range of designs and material types of the spinal implant cages that can be used in spinal fusion. Posterior lumbar interbody fusion (PLIF) cage is used to preserve stability and stimulate fusion between vertebrae. There are four different types of biomaterials that can be used to produce the cage namely as metal, ceramic, polymer and composite. The objective of this project is to examine the interbody fusion effects of a several type of cage’s materials. A 3D finite element model of third (L3) and fourth lumbar (L4) vertebrae with interbody fusion made up of different types of cage’s materials namely as Polyether ether ketone (PEEK), poly lactic acid (PLA), Cobalt Chromium, Titanium Alloy and Stainless Steel were developed and analysed. A fusion model developed based on the respective surgical protocols. The resulting stress and displacement within the cage at the vertebra were measured under different types of compressive loadings and motions. The results indicated an important effects of the material properties on flexibility in extension, axial rotation and lateral bending. Titanium Alloy have been identified as a good material for the metal categories, while for the composite categories PLA (Polylactic acid) has also been simulated as the best alternative material with cheaper material and lower production costs.

show abstract

Section: Fig 2: Type Of Spinal Surgery Option [4]mentioning

confidence: 98%

Biomechanical Analysis of Spinal Fusion Cage for Lumbar Vertebrae

Yahya¹,

Mazlan²,

Shuib³

et al. 2019

IJRTE

View full text Add to dashboard Cite

show abstract

“…The in vivo depth migration, content, size, and nature of debris in human biopsies were determined by micro-PIXE method associated with RBS. [21] Experimental Section…”

Section: Characterization Of Contamination By Trace Elements Of Tissumentioning

confidence: 99%

Quantitative Chemical Mapping of Relevant Trace Elements at Biomaterials/Biological Media Interfaces by Ion Beam Methods

et al. 2010

View full text Add to dashboard Cite

The definition of biomaterial as proposed by the European Society for Biomaterials in 1986 puts forward the overall importance of the notion of contact between the biomaterial and biological medium (cell, tissue, fluid,...). The underlying concept of biocompatibility makes the interface between biomaterial and biological medium a privileged zone of interest. In this paper, we would like to give an exhaustive view of how ion beams techniques can contribute to a better understanding of such interface taking several examples dealing with bone tissue substitution. After a short presentation of ion beams techniques the paper will focus on PIXE/RBS spectroscopies and will give the basics of these coupled technique. Three examples will then be presented to illustrate the interest of these techniques to study biomaterials/biological interactions. The first example deals with metallic alloys based joint prostheses. The ionic release from the prosthesis and the wear behavior of total knee prostheses will be presented. In the last two examples, bioactive materials will be studied. The common characteristic of bioactive ceramics is the kinetic modification of their surface upon interaction which is ideally monitored by PIXE chemical mapping. The second example will review the benefit of using PIXE/RBS technique to study the effect of doping of bioactive glasses on the very first steps involved in the bioactivity mechanisms like dissolution, ionic release, and biomineralization onto the surface of the glasses. Finally, protein delivery systems based upon mesoporous hydroxyapatites will be studied. Chemical mapping allowing the quantitative determination of protein distribution inside the HAp grains will be presented for the first time

show abstract

“…Metal ions and biomaterial debris are released into peri-implant tissues as a result of corrosion and after this they can be transported by blood [Ti(IV) ions bound to transferrin] to other biocompartments (tissues) (Soto-Alvaredo et al 2014 ; Zierden and Valentine 2016 ). But some studies reported that metallic debris did not migrate deep into the tissue around implant (Guibert et al 2006 ) or the leakage of Ti to adjacent bone and later to organism was limited (Passi et al 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Does titanium in ionic form display a tissue-specific distribution?

et al. 2016

View full text Add to dashboard Cite

Most studies have focused on the biodistribution of titanium(IV) oxide as nanoparticles or crystals in organism. But several reports suggested that titanium is released from implant in ionic form. Therefore, gaining insight into toxicokinetics of Ti ions will give valuable information, which may be useful when assessing the health risks of long-term exposure to titanium alloy implants in patients. A micro synchrotron radiation-induced X-ray fluorescence (µ-SRXRF) was utilized to investigate the titanium distribution in the liver, spleen and kidneys of rats following single intravenous or 30-days oral administration of metal (6 mg Ti/b.w.) in ionic form. Titanium was mainly retained in kidneys after both intravenous and oral dosing, and also its compartmentalization in this organ was observed. Titanium in the liver was non-uniformly distributed—metal accumulated in single aggregates, and some of them were also enriched in calcium. Correlation analysis showed that metal did not displace essential elements, and in liver titanium strongly correlated with calcium. Two-dimensional maps of Ti distribution show that the location of the element is characteristic for the route of administration and time of exposure. We demonstrated that µ-SRXRF can provide information on the distribution of titanium in internal structures of whole organs, which helps in enhancing our understanding of the mechanism of ionic titanium accumulation in the body. This is significant due to the popularity of titanium implants and the potential release of metal ions from them to the organism.

show abstract

Characterisation by PIXE–RBS of metallic contamination of tissues surrounding a metallic prosthesis on a knee

Cited by 15 publications

References 56 publications

Biomechanical Analysis of Spinal Fusion Cage for Lumbar Vertebrae

Biomechanical Analysis of Spinal Fusion Cage for Lumbar Vertebrae

Quantitative Chemical Mapping of Relevant Trace Elements at Biomaterials/Biological Media Interfaces by Ion Beam Methods

Does titanium in ionic form display a tissue-specific distribution?

Contact Info

Product

Resources

About