2024
DOI: 10.1038/s44298-024-00025-5
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Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak

Wilson Nguyen,
Narayan Gyawali,
Romal Stewart
et al.

Abstract: Human infections with the Japanese encephalitis virus (JEV) are a leading cause of viral encephalitis. An unprecedented outbreak of JEV genotype 4 was recently reported in Australia, with an isolate (JEVNSW/22) obtained from a stillborn piglet brain. Herein we conduct a thorough characterization of JEVNSW/22 in three different mouse strains and in human cortical brain organoids (hBOs), and determined the ability of JEVNSW/22 to be neutralized by sera from humans vaccinated with IMOJEV. JEVNSW/22 was less virul… Show more

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Cited by 7 publications
(1 citation statement)
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“…Four isolates of JEV were used in the vector competence experiments: TS00 (GI), FU (GII), JKT6468 (GIV) and the recently emerged Australian isolate O-0883/NSW/2022 (NSW/22; GIV) [38]. JEV JKT6468 was isolated from Cx.…”
Section: Virusesmentioning
confidence: 99%
“…Four isolates of JEV were used in the vector competence experiments: TS00 (GI), FU (GII), JKT6468 (GIV) and the recently emerged Australian isolate O-0883/NSW/2022 (NSW/22; GIV) [38]. JEV JKT6468 was isolated from Cx.…”
Section: Virusesmentioning
confidence: 99%