Characterisation of Antibodies Specific for Chick Brain Neural Cell Adhesion Molecules Which Cause Amnesia for a Passive Avoidance Task

Mileusnic, Radmila; Rose, Steven; Lancashire, Christine L.; Bullock, Sarah

doi:10.1046/j.1471-4159.1995.64062598.x

Cited by 39 publications

(10 citation statements)

References 55 publications

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“…Over the years, using traditional biochemistry, a few genes were correlated with memory formation in the IMHV (Rose, 2000). A pivotal attention was directed toward the role of N‐CAM, where both correlative (Mileusnic et al ., 1995) and interventive approaches (Mileusnic et al ., 1999) indicated its role in memory formation in the IMHV. Our present differential display findings indicate that the mRNA of N‐CAM is induced after training.…”

Section: Discussionmentioning

confidence: 99%

Cyclin S: a new member of the cyclin family plays a role in long‐term memory

Edelheit

Meiri

2004

Eur J of Neuroscience

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Memory is thought to be subserved by structural and functional alteration in synaptic connectivity. But although neuronal plasticity requires gene expression, the identity of the proteins involved is largely unknown. Using the chick 1-day-old passive avoidance learning paradigm and differential display RNA fingerprinting, we identified 13 candidate genes which are upregulated in the intermediate medial hyperstriatum ventrale (IMHV), an area that has been correlated with the initial processing of memory formation. One of the induced genes is a new member of the cyclin family, with high homology to cyclin L (ania-6a). Analysis of the expression pattern of this gene after training revealed two time waves of induction: the first correlated with learning and initial memory process in the IMHV; the second correlated with memory consolidation, first in the IMHV, and then in the lobus paraolefactoris. There is a correlation between methylanthranilate (MeA) concentrations (the malaise substrate in the passive avoidance training procedure), the duration of memory and the expression level of cyclin S. While training chicks on low concentrations of MeA causes short-term memory and low expression level of cyclin S, high concentration of MeA induces long-term memory and high expression level of cyclin S in the IMHV. The role of cyclins in the regulation of neuronal-plasticity-related gene expression was overlooked, and it might serve as a key step in long-term memory formation.

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Section: Discussionmentioning

confidence: 99%

Cyclin S: a new member of the cyclin family plays a role in long‐term memory

Edelheit

Meiri

2004

Eur J of Neuroscience

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“…NCAM knockout mice showed deficiency in learning in the Morris water maze test [35] . Amnesia was induced in rats and chicks injected with NCAM antibody [36,37] . In the present study, the total NCAM mRNA level was found to decrease in group H1 and increase up to the basal level after repeated exposure to hypoxia in group H4.…”

Section: Discussionmentioning

confidence: 99%

Hypoxic Preconditioning Improves Spatial Cognitive Ability in Mice

et al. 2006

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Although it has been reported in a lot of studies that hypoxic preconditiong could protect the brain from hypoxic/ischemic injury, it is not clear whether hypoxic preconditioning could affect brain functions such as cognitive ability. This work aims at investigating the effect of hypoxic preconditioning on spatial cognitive ability in mice after acute and repeated hypoxic exposures. The mice were randomly divided into 3 groups: a control group in which mice were not exposed to hypoxia (H0) and experimental groups in which mice encountered hypoxia either once (H1) or 4 times (H4). Neural cell adhesion molecule (NCAM) expression, long-term potentiation (LTP) recording and Morris water maze test were used to measure the animals’ cognitive ability. The tolerance time was progressively prolonged as exposure went on. The expression of both NCAM mRNA and NCAM protein as well as the LTP induction rate decreased in group H1, but recovered to control level in group H4. The performance of mice in the maze test was improved in H4 in comparison with that in both H1 and H0. These findings may indicate that spatial cognitive ability is improved in adult mice by their hypoxic preconditioning.

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“…For example, NCAMknockout mice demonstrate deficits in spatial learning (Cremer et al, 1994), and injections of synthetic peptides that interfere with NCAM homophilic binding (Cambon et al, 2003) or injections of NCAM antibodies (Mileusnic et al, 1995;Scholey et al, 1993), impair learning and memory processes in rats and chicks (Alexinsky et al, 1997;Arami et al, 1996;Doyle et al, 1992b). Moreover, intracerebroventricular administration of NCAM antibodies after training rats in an olfactory discrimination task disrupts subsequent retention of this task (Roullet et al, 1997).…”

Section: Ncam Modulation Is Specific To Its Polysialylated Statementioning

confidence: 99%

Olfactory learning-related NCAM expression is state, time, and location specific and is correlated with individual learning capabilities

et al. 2005

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The notion that long-term synaptic plasticity is generated by activity-induced molecular modifications is widely accepted. It is well established that neural cell adhesion molecule (NCAM) is one of the prominent modulators of synaptic plasticity. NCAM can be polysialylated (PSA-NCAM), a reaction that provides it with anti-adhesion properties. In this study we have focused on NCAM and on its polysialylated state, and their relation to learning of an olfactory discrimination task, which depends on both the piriform (olfactory) cortex and hippocampus. We trained rats to distinguish between pairs of odors until rule learning was achieved, a process that normally lasts 6-8 days. At four time points, during training and after training completion, synaptic NCAM and PSA-NCAM expression were assessed in the piriform cortex and hippocampus. We report that NCAM modulation is specific to PSA-NCAM, which is upregulated in the hippocampus one day after training completion. We also report a correlation between the performance of individual rats in an early training stage and their NCAM expression, both in the piriform cortex and hippocampus. Since individual early performance in our odor discrimination task is correlated with the performance throughout the training period, we conclude that early NCAM expression is associated with odor learning capability. We therefore suggest that early synaptic NCAM expression may be one of the factors determining the capability of rats to learn.

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Characterisation of Antibodies Specific for Chick Brain Neural Cell Adhesion Molecules Which Cause Amnesia for a Passive Avoidance Task

Cited by 39 publications

References 55 publications

Cyclin S: a new member of the cyclin family plays a role in long‐term memory

Cyclin S: a new member of the cyclin family plays a role in long‐term memory

Hypoxic Preconditioning Improves Spatial Cognitive Ability in Mice

Olfactory learning-related NCAM expression is state, time, and location specific and is correlated with individual learning capabilities

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