Characterisation of carotid plaques with ultrasound elastography: feasibility and correlation with high-resolution magnetic resonance imaging

Naïm, Cyrille; Cloutier, Guy; Mercure, Elizabeth; Destrempes, François; Zhao, Qian; El-Abyad, Walid; Lanthier, Sylvain; Giroux, Marie‐France; Soulez, Gilles

doi:10.1007/s00330-013-2772-7

Cited by 59 publications

(44 citation statements)

References 32 publications

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“…In addition, in vitro investigations in postmortem human coronary arteries have revealed that elastography can identify vulnerable plaques with a sensitivity of 88% and a specificity of 89% (Schaar et al 2003). A recently published investigation used strain analysis with noninvasive elastography to characterize the composition and vulnerability of carotid plaques, with highresolution magnetic resonance imaging as a reference technique: the presence of a lipid core could be detected by elastography with high sensitivity and moderate specificity (Naim et al 2013). The present study is the first to comprehensively describe the utility of RTE as a noninvasive technique in a small artery (the carotid artery) and to correlate the elastography data with pathologic findings.…”

Section: Discussionmentioning

confidence: 97%

Real-Time Tissue Elastography for the Detection of Vulnerable Carotid Plaques in Patients Undergoing Endarterectomy: A Pilot Study

Liu

Qiang

Zhang

et al. 2015

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 97%

Real-Time Tissue Elastography for the Detection of Vulnerable Carotid Plaques in Patients Undergoing Endarterectomy: A Pilot Study

Liu

Qiang

Zhang

et al. 2015

Ultrasound in Medicine & Biology

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“…With this preclinical model, we could confirm the feasibility of NIVE for the characterization of endoleaks and thrombus organization after EVAR. The LSME algorithm estimated the strain transmitted by cardiac pulsation inside the aneurysm sac by computing axial and lateral strain and shear maps from RF US images (16)(17)(18)(19). No external compression or radiation force was needed.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, to generate the elastogram, there is no need to use a low-frequency radiation force, as with the acoustic radiation force impulse imaging technique, or a supersonic shear wave, as with supersonic imaging techniques. NIVE was first developed to help characterize carotid atherosclerotic lesions (19 Angiography.-Digital subtraction angiography (Koordinat 3D; Siemens Medical Solutions, Forchheim, Germany) was performed at baseline, before and during implantation of the stentgraft, and at sacrifice by the same interventional radiologist (G.S.). A pigtail catheter (4 or 5 F) was inserted in the abdominal aorta.…”

Section: Implication For Patient Carementioning

confidence: 99%

Endovascular Repair of Abdominal Aortic Aneurysm: Follow-up with Noninvasive Vascular Elastography in a Canine Model

Salloum¹,

Bertrand-Grenier²,

Lerouge³

et al. 2016

Radiology

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Purpose:To assess the ability of noninvasive vascular elastography (NIVE) to help characterize endoleaks and thrombus organization in a canine model of abdominal aortic aneurysm after endovascular aneurysm repair with stent-grafts, in comparison with computed tomography (CT) and pathologic examination findings. Materials and Methods:All protocols were approved by the Animal Care Committee in accordance with the guidelines of the Canadian Council of Animal Care. Stent-grafts were implanted in a group of 18 dogs with aneurysms created in the abdominal aorta. Type I endoleak was created in four aneurysms; type II endoleak, in 13 aneurysms; and no endoleak, in one aneurysm. Doppler ultrasonography and NIVE examinations were performed at baseline and at 1-week, 1-month, 3-month, and 6-month follow-up. Angiography, CT, and macroscopic tissue examination were performed at sacrifice. Strain values were computed by using the Lagrangian speckle model estimator. Areas of endoleak, solid organized thrombus, and fresh thrombus were identified and segmented by comparing the results of CT and macroscopic tissue examination. Strain values were compared by using the Wilcoxon rank-sum and Kruskal-Wallis tests. Results:All stent-grafts were successfully deployed, and endoleaks were clearly depicted in the last follow-up elastography examinations. Maximal axial strains over consecutive heart cycles in endoleak, organized thrombus, and fresh thrombus areas were 0.78% 6 0.22, 0.23% 6 0.02, 0.10% 6 0.04, respectively. Strain values were significantly different between endoleak and organized or fresh thrombus areas (P , .000) and between organized and fresh thrombus areas (P , .0002). No correlation was found between strain values and type of endoleak, sac pressure, endoleak size, and aneurysm size. Conclusion:NIVE may be able to help characterize endoleak and thrombus organization, regardless of the size, pressure, and type of endoleak.q RSNA, 2015

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“…MRI images were segmented by a trained radiologist [9], inner and outer contours of the wall as well as inclusion contours (i.e., lipid and calcium) were extracted and used in a PFEM to model thedisplacement field and strain behavior of the plaques (see Fig. 2).…”

Section: A Fem Model From True In Vivomri Geometriesmentioning

confidence: 99%

Non-invasive vascular modulography: An inverse problem method for imaging the local elasticity of atherosclerotic carotid plaques

Porée

Garcia

Chayer

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Quantifying biomechanicalproperties of atherosclerotic plaques may help preventing strokes. Noninvasive vascular elastography (NIVE) in superficial carotid arteries has the potential to assess such properties and to discriminate plaque components (e.g., fibrosis, lipid and calcium) through elastograms (i.e., spatial strain distribution). However, the elasticity and morphology of the vessel wall, cannot be assessed directly from strain maps since the stress distribution remains unknown. In this study, we describe an unsupervised inverse problem for elasticity mapping (non invasive vascular modulography), which is capable of reconstructing a heterogeneous Young's modulus distribution of a plaque. High resolution elastograms were computed from ultrasound compounded plane wave images using the constrained lagrangian speckle model estimator (constrained LSME). Von mises strain maps were combined with a stress map, evaluated using a parametric finite element model (PFEM), and used to highlight mechanical heterogeneities and compute Young modulus maps (Modulograms).

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Characterisation of carotid plaques with ultrasound elastography: feasibility and correlation with high-resolution magnetic resonance imaging

Cited by 59 publications

References 32 publications

Real-Time Tissue Elastography for the Detection of Vulnerable Carotid Plaques in Patients Undergoing Endarterectomy: A Pilot Study

Real-Time Tissue Elastography for the Detection of Vulnerable Carotid Plaques in Patients Undergoing Endarterectomy: A Pilot Study

Endovascular Repair of Abdominal Aortic Aneurysm: Follow-up with Noninvasive Vascular Elastography in a Canine Model

Non-invasive vascular modulography: An inverse problem method for imaging the local elasticity of atherosclerotic carotid plaques

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