Characterisation of clotting factors, anticoagulant protein activities and viscoelastic analysis in healthy donkeys

Pérez-Écija, Alejandro; Mendoza, Francisco J.

doi:10.1111/evj.12685

Cited by 15 publications

(10 citation statements)

References 20 publications

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“…Physiological differences have been demonstrated between donkeys and horses, for example, in haematology, biochemistry and haemostatic variables , and also regarding metabolic and endocrine hormonal regulation . Thus, extrapolating data and diagnostic protocols between species could lead to misdiagnosis and subsequent inappropriate management in false‐negative cases as well as unnecessary treatments and financial expenses in false‐positive cases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of dynamic testing for pituitary pars intermedia dysfunction diagnosis in donkeys

Mejia‐Pereira¹,

Pérez-Écija

Buchanan³

et al. 2018

Equine Veterinary Journal

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Summary Background Endocrine disorders are common in donkeys. Pituitary pars intermedia dysfunction (PPID) is thought to be a frequent disturbance in donkeys due to their longevity. However, information on PPID dynamic testing in donkeys is lacking. Objectives The objective of this study was to evaluate the previously described guidelines for PPID diagnosis in horses in donkeys with suspicion of PPID. Study design Prospective experimental study. Methods Eighty donkeys were evaluated for PPID suspicion based on clinical signs and baseline adrenocorticotropic hormone (ACTH) concentrations. Six mix‐breed donkeys (one jack and five non‐pregnant jennies) fulfilling inclusion criteria were subjected to dexamethasone suppression test (DST), thyrotropin‐releasing hormone stimulation test (TRH) and combined DST–TRH challenge. Tests were interpreted according to guidelines for PPID diagnosis in horses. Results Donkeys fulfilling inclusion criteria were diagnosed with PPID by TRH stimulation test (six of six). Both DST (three of six) and DST–TRH (4/6) challenges failed to detect those animals and showed conflicting results. Similarly, cortisol basal concentrations were not consistent with PPID suspicion. Main limitations Characterisation of seasonal and geographical location effect on baseline ACTH concentrations and response to TRH is compelling in this species. Further studies with a larger number of donkeys are needed. Conclusions This is the first study in donkeys to evaluate common dynamic tests used for PPID diagnosis in horses. Preliminary results agree with the guidelines for PPID diagnosis in horses and baseline ACTH measurement followed by TRH challenge are recommended tests for diagnosis of PPID in donkeys.

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Section: Introductionmentioning

confidence: 99%

Evaluation of dynamic testing for pituitary pars intermedia dysfunction diagnosis in donkeys

Mejia‐Pereira¹,

Pérez-Écija

Buchanan³

et al. 2018

Equine Veterinary Journal

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“…According to reports, there are many differences between donkeys and horses. Therefore, clinical data, treatment and diagnostic protocols from horse to donkey may lead to misdiagnosis and unnecessary or inadequate treatment [ 1 ]. It was found that cardiovascular disease is underreported in donkeys, possibly related to their limited athletic posture and frequent poor performance-related examinations.…”

Section: Introductionmentioning

confidence: 99%

Reference Values and Repeatability of Pulsed Wave Doppler Echocardiography Parameters in Normal Donkeys

Marzok

Almubarak

Mohamad

et al. 2022

Animals

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In the present study, thirty clinically healthy donkeys were used to establish the reference values and repeatability for Pulsed Wave Doppler echocardiographic variables of the mitral valve, aortic valve and myocardial performance. 2-dimensional Color flow mapping and spectral Doppler modes were performed. For the mitral valve, the mean velocity, pressure gradient and duration of E-wave were 57.7 ± 12.5 cm/s, 1.4 ± 0.7 mmHg and 0.4 ± 0.13 s, respectively. The velocity, pressure gradient and duration of the A-wave were 32.3 ± 9.1 cm/s, 0.3 ± 0.04 mmHg and 0.3 ± 0.1 s, respectively. The mitral valve area, pressure half time, pulsatility index (PI), resistance index (RI) and velocity time integral (VTI) were 1.8 ± 0.5 cm2, 66 ± 17 ms, 2.8 ± 1.4, 0.9 ± 0.03 and 19.1 ± 5.7 cm, respectively. For the aortic valve, the mean velocity was 64.9 ± 10.4 cm/s, pressure gradient was 1.8 ± 0.4 mmHg, pulsatility index was 1.4 ± 0.3, resistance index was 0.9 ± 0.02, VTI was 25.02 ± 6.2 cm, systolic/diastolic was 19 ± 4.7 and heart rate was 95.7 ± 28.9 per minute. For Myocardial Performance Index (LV)–Tei Index, the mean ejection, isovolumic relaxation, isovolumic contraction time and myocardial performance index were 0.24 ± 0.01, 0.14 ± 0.01, 0.14 ± 0.02 and 1.2 ± 0.1 s, respectively. The results of the present study provide the reference values of PW echocardiographic parameter measurements in normal adult donkeys. Such reference values are helpful, especially when confronted with clinical cases with cardiovascular disorders.

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“…Interest in donkeys has been increasing in recent years in developed countries, in particular related to assisted therapies for people with psychomotor and mental disabilities, as an alternative source of milk for people with cow's milk intolerance, in certain sport competitions and as companion animals [1]. Donkeys are afflicted by similar pathologies as horses, however, due to physiological and pharmacological differences between donkeys and horses [2][3][4], a speciesspecific approach should be considered when dealing with diagnostics and therapies in donkeys.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the combined glucose‐insulin and intravenous glucose tolerance tests for insulin dysregulation diagnosis in donkeys

Mendoza

Mejia-Moreira²,

Buchanan³

et al. 2021

Equine Veterinary Journal

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Characterisation of clotting factors, anticoagulant protein activities and viscoelastic analysis in healthy donkeys

Abstract: The haemostatic system in donkeys differs from that in horses and extrapolation of reference values between these species is not appropriate.

Cited by 15 publications

References 20 publications

Evaluation of dynamic testing for pituitary pars intermedia dysfunction diagnosis in donkeys

Evaluation of dynamic testing for pituitary pars intermedia dysfunction diagnosis in donkeys

Reference Values and Repeatability of Pulsed Wave Doppler Echocardiography Parameters in Normal Donkeys

Evaluation of the combined glucose‐insulin and intravenous glucose tolerance tests for insulin dysregulation diagnosis in donkeys

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