Characterisation of Hyaluronic Acid Blends Modified by Poly(N-Vinylpyrrolidone)

Lewandowska, Katarzyna; Szulc, Marta

doi:10.3390/molecules26175233

Cited by 4 publications

(1 citation statement)

References 38 publications

(72 reference statements)

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“…The F1 formulation demonstrated thixotropic behavior with pseudoplastic flow, a desired property for topical medication formulations. This flow characteristic of formulations containing CS could be the consequence of shear, which breaks down the structural arrangement by rupturing the intermolecular bonds between polymeric chains (Lewandowska and Szulc, 2021).…”

Section: Rheologic Characteristics Of the Psz-co-cs Ne Formulationsmentioning

confidence: 99%

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders

Alissa,

Hjazi,

Abusalim

et al. 2024

Front. Pharmacol.

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Introduction: Essential oil‒based nanoemulsions (NEs) are the subjects of extensive investigation due to their potential to address a variety of oral health issues. NEs are delivery systems that improve lipid medicine solubility and distribution to intended sites. The goal of the current study was to create and enhance a self-nanoemulsifying drug delivery paradigm based on calendula oil (CO) and decorated with chitosan (CS) that could deliver posaconazole (PSZ) for the treatment of gingivitis.Method: Employing a response-surface Box‒Behnken design, PSZ-CO-CS NEs were created with varying amounts of PSZ (10, 15, and 20 mg), percentages of CO (6%, 12%, and 18%), and percentages of CS (0.5%, 1.5%, and 2.5%).Results and conclusion: The optimized formulation resulted in a 22-mm bacterial growth suppression zone, 25-mm fungal growth inhibition zone, droplet sizes of 110 nm, and a viscosity of 750 centipoise (cP). Using the appropriate design, the ideal formulation was produced; it contained 20 mg of PSZ, 18% of CO, and 1.35% of CS. Furthermore, the optimal formulation had a more controlled drug release, larger inhibition zones of bacterial and fungal growth, and desirable rheologic properties. Additionally, the optimized formulation substantially lowered the ulcer index in rats when tested against other formulations. Thus, this investigation showed that PSZ-CO-CS NEs could provide efficient protection against microbially induced gingivitis.

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Section: Rheologic Characteristics Of the Psz-co-cs Ne Formulationsmentioning

confidence: 99%

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders

Alissa,

Hjazi,

Abusalim

et al. 2024

Front. Pharmacol.

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Friction and Lubrication of Eye/Lens/Lid Interface: The Effect of Lubricant and Contact Lens Material

Nečas,

Kulíšek,

Štěpán

et al. 2023

Tribol Lett

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Irritation of the eye in the case of contact lens users may imply dry eye syndrome (DES), commonly treated by eye drops. The paper focuses on measuring the friction coefficient with the simultaneous observation of lubricating film formation of the simulated eye/lens/lid interface. The experiments are performed in a pin-on-plate setup under the linear reciprocal motion. The contact is lubricated by twelve different solutions as the potential ingredients for eye drops, focusing on the role of mucin, buffer type, and molecular weight (MW) of hyaluronic acid (HA). Two commercially available contact lenses are studied, while overall lens performance is evaluated, among others. The results showed that the lens material, the presence of mucin, and the type of buffer have a decisive influence on the contact behavior. Specifically, it is concluded that the selection of eye drops should reflect the type of lens the wearers use and the conditions of their tear film. The appropriate ingredient for Acuvue Oasys and Biofinity contact lenses is suggested based on the score of the biotribological performance of the lubricant, taking both friction and lubrication into account.

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Double-layer dissolving microneedles for delivery of mesenchymal stem cell Secretome: Formulation, characterisation and skin irritation study

Nainggolan,

Hartrianti,

Anjani

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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Characterisation of Hyaluronic Acid Blends Modified by Poly(N-Vinylpyrrolidone)

Cited by 4 publications

References 38 publications

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders

Friction and Lubrication of Eye/Lens/Lid Interface: The Effect of Lubricant and Contact Lens Material

Double-layer dissolving microneedles for delivery of mesenchymal stem cell Secretome: Formulation, characterisation and skin irritation study

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