In this paper, we present and compare two different full-band WR3.4 Sub-Harmonic Mixers (SHMs), featuring traditional GaAs and the novel low-barrier InGaAs discrete diodes. In this study, an Active Multiplier Chain (AMC) is used as a Local Oscillator source, which provides peak powers beyond 20 mW. The GaAs mixer presents Single-Sideband (SSB) Conversion Loss (CL) of 10 dB and Double-Sideband (DSB) Noise Temperature (NT) of 3000 K across the entire RF and IF bands when an LO power of 6–10 mW is applied. The low-barrier mixer featuring the new and improved batch of InGaAs diodes performs SSB Conversion Loss of 15 dB and DSB Noise Temperature of 9000 K, using LO powers of 0.5 mW. In this work, a comparison of the CL and NT of both mixers is carried out, highlighting the excellent performances of GaAs diodes and the minimum LO power requirements needed by InGaAs counterparts, as well as future perspectives in InGaAs mixer performances. The mixers and diodes were fully designed, fabricated, and tested at ACST GmbH.