Characterisation of N-terminal pro-brain natriuretic peptide in dialysis patients and its reduced prognostic significance in the elderly

Sato, Yuji; Ishizaki, Yuri; Aso, Kumiko; Minakwa, Akihiro; Toida, Tatsunori; Nishizono, Ryuzoh; Kikuchi, Masao; Inagaki, Hiroko; Fujimoto, Shouichi

doi:10.1038/s41598-019-43253-z

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…In addition to the LA, NT-proBNP can also reflect cardiac diastolic function. Previous research has shown that NT-proBNP ranges from 3,703 to 6,360 pg/mL in HD patients [32,33]. The mean NT-proBNP level in our study was 4,220 ng/L (range, 2,086-11,025 ng/L), which is consistent with previous research reports.…”

Section: Discussionsupporting

confidence: 92%

Hemodynamic factors affecting pulmonary hypertension in hemodialysis patients

Zhang,

Xiao,

et al. 2023

Kidney Res Clin Pract

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Background:The fluid status and rate of blood flow through the arteriovenous fistula (AVF) are two important factors affecting hemodynamic in hemodialysis patients; however, their effects on pulmonary hypertension have rarely been studied. Hence, we aimed to evaluate the effects of these factors in hemodialysis patients with pulmonary hypertension. Methods: This single-center cross-sectional survey included 219 maintenance hemodialysis patients (139 [63.5%] male). The prevalence of pulmonary hypertension was 13.6% (30 of 219). Pulmonary artery pressure was measured by echocardiography, fluid status was measured objectively using bioimpedance spectroscopy, and blood flow rate in the AVF (Qa) was determined using Doppler ultrasound.Results: The overall mean overhydration before hemodialysis was 1.5 L (range, 0.6-2.8 L). The mean overhydration in patients with and without pulmonary hypertension was 3.6 L (range, 2.3-4.6 L) and 1.4 L (range, 0.6-2.4 L), respectively (p < 0.001). The overall mean Qa was 780 mL/min (range, 570-1,015.5 mL/min). The mean Qa of patients with and without pulmonary hypertension was 672 mL/min (range, 505.7-982.2 mL/min) and 790 mL/min (range, 591-1,026 mL/min), respectively (p = 0.27). Overhydration (odds ratio [OR], 1.46; 95% confidence interval [CI], 1.08-1.97; p = 0.01), N-terminal prohormone of brain natriuretic peptide (NT-proB-NP; OR, 1.36; 95% CI, 1.09-1.71; p = 0.007), and left atrial diameter (OR, 1.14; 95% CI, 1.01-1.28; p = 0.03) were risk factors. Conclusion: Pulmonary hypertension is strongly associated with overhydration, NT-proBNP, and left atrial diameter in hemodialysis patients.

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Section: Discussionsupporting

confidence: 92%

Hemodynamic factors affecting pulmonary hypertension in hemodialysis patients

Zhang,

Xiao,

et al. 2023

Kidney Res Clin Pract

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“…The main outcome of this study was late discharge (postmenstrual age at discharge was in the fourth quartile (highest) among infants born at the same GA). In supplementary analyses, we also analyzed total costs during hospitalization and the major neonatal morbidities that may prolong the length of hospital stay, including BPD [defined as oxygen dependency at 36 weeks' corrected GA ( 21 )], NEC [stage 2 or higher NEC according to the criteria of Bell et al ( 22 )], and nosocomial infection [defined as meningitis or culture-positive sepsis ( 23 )].…”

Section: Methodsmentioning

confidence: 99%

Association Between NT-proBNP and Prolonged Length of Stay in Hospital Among Preterm Infants Born at 28–31 Weeks' Gestation

Luo

Lei

et al. 2022

Front. Pediatr.

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ObjectiveIn the early life of preterm infants, the relationship between heart function and length of hospitalization is unclear. This study aims to examine the association between serum NT-proBNP level on the 7th day (NT-proBNP7) after birth and length of hospitalization among preterm infants.MethodsA retrospective cohort study was conducted. Patients included 709 preterm infants born at 28–31 weeks' gestational age (GA) admitted to the NICU of the First Affiliated Hospital of Zhengzhou University between December 20, 2016, to April 31, 2021. Main outcome: Late discharge (postmenstrual age at discharge was in the fourth quartile (highest) among infants born at the same GA). Exposure factor: NT-proBNP7.ResultsWe observed increased prevalence ratios for late discharge among the tertile of logarithm of NT-proBNP7 level (LnNT-proBNP7) which was positive. Compared with the lowest tertile, infants in the highest tertile of LnNT-proBNP7 had an 8.4-fold increased probability of late discharge, and the results were consistent for the subgroups. Next, a non-linear (S-shaped) relationship between LnNT-proBNP7 and late discharge was observed, whose turning points were 7.5 and 9. The effect sizes and the confidence intervals on the left of the first turning point, between two turning points and on the right of the second turning point, were 0.6 (95% CI, 0.2–1.6), 5.0 (95% CI, 2.4–10.6), and 1.1 (95% CI, 0.2–6.1), respectively. In addition, the prevalence of BPD, NEC, nosocomial infection, or any of them was highest in the group of LnNT-proBNP7 ≥ 9, lowest in the group of LnNT-proBNP7 < 7.5.ConclusionHigher NT-proBNP7 levels were associated with longer hospitalization. The relationship between LnNT-proBNP7 and late discharge was S-shaped. LnNT-proBNP7 was positively related with late discharge when LnNT-proBNP7 was between 7.5 and 9.

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“…For chronic cases, on the other hand, neprilysin (responsible for the degradation of ANP and BNP) (34) inhibitor is used. Recent studies reported that human proBNP, in bloodstream and its post-translational modification at the N-terminal region could lead to its higher levels in cardiac patients (35).…”

Section: Peptide Hormonesmentioning

confidence: 99%

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

2020

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Diabetic cardiomyopathy (DCM) is an outcome of disturbances in metabolic activities through oxidative stress, local inflammation, and fibrosis, as well as a prime cause of fatality worldwide. Cardiovascular disorders in diabetic individuals have become a challenge in diagnosis and formulation of treatment prototype. It is necessary to have a better understanding of cellular pathophysiology that reveal the therapeutic targets and prevent the progression of cardiovascular diseases due to hyperglycemia. Critical changes in levels of collagen and integrin have been observed in the extracellular matrix of heart, which was responsible for cardiac remodeling in diabetic patients. This review explored the understanding of the mechanisms of how the phytochemicals provide cardioprotection under diabetes along with the caveats and provide future perspectives on these agents as prototypes for the development of drugs for managing DCM. Thus, here we summarized the effect of various plant extracts and natural polyphenols tested in preclinical and cell culture models of diabetic cardiomyopathy. Further, the potential use of selected polyphenols that improved the therapeutic efficacy against diabetic cardiomyopathy is also illustrated.

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Characterisation of N-terminal pro-brain natriuretic peptide in dialysis patients and its reduced prognostic significance in the elderly

Cited by 6 publications

References 33 publications

Hemodynamic factors affecting pulmonary hypertension in hemodialysis patients

Hemodynamic factors affecting pulmonary hypertension in hemodialysis patients

Association Between NT-proBNP and Prolonged Length of Stay in Hospital Among Preterm Infants Born at 28–31 Weeks' Gestation

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

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