Characterisation of nosocomial and community-acquired influenza in a large university hospital during two consecutive influenza seasons

Huzly, Daniela; Kurz, Sven; Ebner, Winfried; Dettenkofer, Markus; Panning, Marcus

doi:10.1016/j.jcv.2015.10.016

Cited by 43 publications

(41 citation statements)

References 17 publications

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“…8 A German group recently reported the proportion of hospital-acquired influenza virus infection as 20.5%-24.6%. 9 Our rate of such infections (28.1%) was somewhat higher than prior reports. Our inclusion of pediatric patients may have been responsible for this.…”

Section: Discussioncontrasting

confidence: 69%

Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital

Choi

Kim

Sung

et al. 2017

American Journal of Infection Control

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Of 7,772 laboratory-confirmed cases of respiratory viral infection among hospitalized patients, 22.8% were categorized as having hospital-acquired infection. The overall incidence of hospital-acquired respiratory viral infection was 3.9 (95% confidence interval, 3.7-4.1) cases per 1,000 admitted patients. Rhinovirus was the most common virus (30.3%), followed by influenza virus (17.6%) and parainfluenza virus (15.6%).

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Section: Discussioncontrasting

confidence: 69%

Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital

Choi

Kim

Sung

et al. 2017

American Journal of Infection Control

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“…In a study over two influenza seasons in Germany, Huzly et al reported a rate of nosocomial transmission of 24% (2012–2013) and 20% (2013–2014) (54). Specific guidelines are available to help prevent transmission of infectious pathogens through isolation precautions (55).…”

Section: Other Viruses Leading To Ardsmentioning

confidence: 99%

Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome

2016

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Viral infections are an important cause of pediatric acute respiratory distress syndrome (ARDS). Numerous viruses, including respiratory syncytial virus (RSV) and influenza A (H1N1) virus, have been implicated in the progression of pneumonia to ARDS; yet the incidence of progression is unknown. Despite acute and chronic morbidity associated with respiratory viral infections, particularly in “at risk” populations, treatment options are limited. Thus, with few exceptions, care is symptomatic. In addition, mortality rates for viral-related ARDS have yet to be determined. This review outlines what is known about ARDS secondary to viral infections including the epidemiology, the pathophysiology, and diagnosis. In addition, emerging treatment options to prevent infection, and to decrease disease burden will be outlined. We focused on RSV and influenza A (H1N1) viral-induced ARDS, as these are the most common viruses leading to pediatric ARDS, and have specific prophylactic and definitive treatment options.

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“…In a tertiary care hospital in France, during the 2016-2017 in uenza A season, 25% of hospitalized infection cases were considered hospital-acquired infection [12] . A German university hospital reported 24% hospital-acquired infection cases in the 2012-2013 in uenza season and 20% in the 2013-2014 season [5] . However, a lower proportion of hospital-acquired cases have been observed in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Hospital-acquired in uenza may be associated with poor prognosis. In Germany, a case fatality rate of 9% has been reported, which was mainly associated with in uenza virus A(H1N1) pdm09 [5] , and in Sweden, a hospital-acquired in uenza A case fatality rate of 9.6% has been reported [6] . Moreover, hospital-acquired in uenza A infection has been reported to be an independent factor associated with mortality among patients admitted to an intensive care unit (ICU) [7] .…”

Section: Introductionmentioning

confidence: 99%

Risk factors for hospital-acquired influenza A and patient characteristics: A matched case-control study

Yang

Zhang

Gao

et al. 2020

Preprint

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Background: Hospital-acquired influenza A brings hospitalized patients an additional cost of care and considerable mortality, but risk factors for hospital-acquired influenza A are unknown. We aimed to describe the characteristics of patients vulnerable for hospital-acquired influenza A and to identify its risk factors. This knowledge would help clinicians to control hospital-acquired infection and reduce the burden of treatment.Methods: A case-control study was conducted in hospitalized patients aged ≥18 years in a tertiary level teaching hospital during the 2018–2019 influenza A season. Patient data were retrieved from hospital-based electronic medical records. Hospital-acquired influenza A was defined as a case of influenza A diagnosed 7 days or more after admission, in a patient who had no evidence of viral respiratory infection on admission. The controls without influenza were selected among patients exposed to the same setting during the same time period. We identified risk factors using conditional logistic regression and described characteristics of patients with hospital-acquired influenza A by comparing the clinical data of the influenza patients and the controls.Results: Of 412 hospitalized patients with influenza A from all departments of the study hospital, 93 (22.6%) cases were classified as hospital-acquired. The most common comorbidities of the 93 cases were hypertension (41.9%), coronary heart disease (21.5%) and cerebrovascular disease (20.4%). Before the onset of hospital-acquired influenza A, patients presented more lymphocytopenia (51.6% vs 35.5%, P=0.027), hypoalbuminemia (78.5% vs 57.0%, P=0.002) and pleural effusion (26.9% vs 9.7%, P=0.002) than matched controls. Notably, infected patients had a longer hospital stay (18 days vs 14 days, P=0.002), and higher mortality (10.8% vs 2.2%, P=0.017). Lymphocytopenia (odds ratio [OR]: 3.11; 95% confidence interval [CI]: 1.24–7.80; P =0.016), hypoalbuminemia (OR: 2.24; 95% CI: 1.10–4.57; P =0.027) and pleural effusion (OR: 3.09; 95% CI: 1.26–7.58; P =0.014) were independently associated with hospital-acquired influenza A.Conclusions: Lymphocytopenia, hypoalbuminemia and pleural effusion were independent risk factors that could help identify patients at high risk of hospital-acquired influenza A, which might extend hospital stay and is associated with a high mortality.

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Characterisation of nosocomial and community-acquired influenza in a large university hospital during two consecutive influenza seasons

Abstract: Despite the different distribution of virus subtypes and epidemiological properties between both influenza seasons, the rate of nosocomial cases remained similar. Systematic detection and targeted prevention measures seem mandatory to minimize nosocomial influenza.

Cited by 43 publications

References 17 publications

Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital

Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital

Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome

Risk factors for hospital-acquired influenza A and patient characteristics: A matched case-control study

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