Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats

Abstract

Assessment of body weight in the present model may not have predictive validity, and other measures may be needed to differentiate between WG-inducing and weight-neutral drugs.

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats

“…Consistent with previous studies, olanzapine caused significant metabolic dysregulation, 22,24,31,[37][38][39][40][41][42][43] evident as elevated fasting glucose levels, insulin resistance (greater HOMA-IR values) and glucose intolerance in the IGTT. To our knowledge, we assessed the effects of metformin, rosiglitazone and glyburide on these metabolic side effects in rats for the first time.…”

Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain

“…The doses were extrapolated from the dose relationship between haloperidol and APZ as used in clinical practice and in previous animal trials with haloperidol and clozapine (Fitzgerald et al 1995;Schmitt et al 2003b). The low (10 mg/kg/day) and high (40 mg/kg/day) doses lie in the range of other animal trials with subcutaneaous (Li et al 2005), oral (Inoue et al 1998;Kalinichev et al 2005) (Dr. Kikutichi, personal communication), or intraperitoneal (Cheng et al 2008;Semba et al 1995;Semba et al 1996) routes of application. APZ treatment showed a tendency to induce weight loss in our system (Segnitz et al 2009) in contrast to the animal study of Kalinichev et al (2005) but quite in concert with clinical observations (Englisch et al 2009;Henderson et al 2009).…”

No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs

“…Clinical studies have shown that olanzapine-induced weight gain among male schizophrenic adolescent inpatients treated for 4 weeks was owing to an increase in caloric intake with little change in resting energy expenditure or physical activity. 35,36 Kalinichev et al 37 reported that female rats treated for 14 days with olanzapine had significant weight Effect of fat on BW gain MB Cope et al gain, hyperphagia, increased body fat, and reduced lean tissue. Baptista et al 38,39 showed similar results for risperidone in female rats attributing the weight gain to increased energy consumption.…”

“…In human studies, the weight gain is mostly comprised of body fat. [53][54][55] Some reports have indicated that most of the weight gain in rodents is body fat, but these reports do not have pre-and post-treatment measures of body composition, only end point determination of body fat 37,38,56,57 Ader et al…”