Characterisation of the anti-inflammatory and antinociceptive activities of the Hyptis pectinata (L.) Poit essential oil

Raymundo, Larissa J.R.P.; Guilhon, Carolina Carvalho; Alviano, Daniela Sales; Matheus, Maria Eline; Antoniolli, Ângelo Roberto; Cavalcanti, Sócrates C.H.; Alves, Péricles Barreto; Alviano, Celuta Sales; Fernandes, Patrícia Dias

doi:10.1016/j.jep.2011.01.027

Cited by 80 publications

(78 citation statements)

References 39 publications

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“…The other primary compounds included humulene epoxide II, α-cadinol, calamusenone and β-elemene, with concentrations below 5%. The presence of caryophyllene oxide as the primary component of H. pectinata essential oil was also observed by other authors (Raymundo et al, 2011;Santos et al, 2008).…”

Section: Resultssupporting

confidence: 81%

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Influence of Drying in Hyptis pectinata Essential Oil

Branquinho¹,

Silva²,

Resende³

et al. 2018

JAS

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The present study assessed the effects of drying at different temperatures (35, 45 and 55 °C) and air velocities (1 and 2 m s -1 ) on the content and chemical characteristics of Hyptis pectinata essential oil. Drying was conducted in a fixed-bed dryer, and the temperatures and air velocities were controlled and recorded by an automated system. A 350±0.12 g quantity of fresh leaves was used for each of the four repetitions in each dryer. From the material obtained after drying, 60 g of each repetition was used to extract essential oil by the hydrodistillation method. Dichloromethane was used as the solvent, and anhydrous sodium sulfate was used as the desiccating agent. Gas chromatography in the forms of GC-MS and GC-FID were used for the chemical characterization of the essential oil compounds. Decreasing drying times and decreasing concentrations of essential oils were observed with increasing temperatures. A GC-MS analysis of the essential oil from H. pectinata leaves led to the identification of 19 compounds. A sesquiterpene called caryophyllene oxide was the most abundant compound under all drying conditions, with the highest concentration at a temperature of 55 °C, ranging from approximately 42 to 53%.

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Section: Resultssupporting

confidence: 81%

“…Raymundo et al (2011) also highlighted this fact and justified the possible presence of monoterpenes in the essential oil from H. pectinata, but at undetectable quantities.…”

Section: Resultsmentioning

confidence: 61%

Influence of Drying in Hyptis pectinata Essential Oil

Branquinho¹,

Silva²,

Resende³

et al. 2018

JAS

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“…(Lamiaceae) produces an essential oil that can be extracted by steam distillation from its dried leaves and inflorescences. This essential oil has several beneficial properties, including antinociceptive, anti-inflammatory, and antimicrobial properties against Gram (+) and Gram (-) strains of bacteria, such as the Candida genus and Cryptococcus neofarman, and antiStreptococcus-mutans activity (Arrigoni- Blank et al, 2008;Raymundo et al, 2011;Santos et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature, the compounds with the highest frequencies of occurrence in the essential oil are β-caryophyllene, ranging from 18.34% to 45.09%, caryophyllene oxide, ranging from 18.00% to 38.05%, and calamusenone, ranging from 24.68% to 48%, in which β-caryophyllene is the main component of the H. pectinata oil (Arrigoni- Blank et al, 2008;Blank et al, 2010;Raymundo et al, 2011;Santos et al, 2008;Silva et al, 2008;Tchoumbougnang et al, 2005). The chemical compositions of the essential oil of the H. pectinata leaves from three different geographical regions also showed variations.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the medicinal value of the essential oil from H. pectinata (Santos Neto et al, 2007) and the fact that several factors may influence its concentration, yield and chemical composition, the objective of the present study was to investigate the influence of storage time in different temperatures on the Hyptis pectinata essential oil of the Active Germplasm Bank of the Federal University of Sergipe (BAG/UFS).…”

Section: Introductionmentioning

confidence: 99%

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Influence of storage time and temperature on the chemical composition of the essential oil of Hyptis pectinata L. Poit

Jesus

Blank

Alves

et al. 2016

Rev. bras. plantas med.

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ABSTRACT:Hyptis pectinata, popularly known as "sambacaitá", is a native medicinal herb used by local people for treating disease. Its pharmacological, antimicrobial, and medicinal properties have been reported in several studies. The essential oil of the leaves is rich in terpene compounds responsible for its properties. Because there are factors that can influence the chemical composition of essential oils, the objective of this study was to evaluate the influence of storage on Hyptis pectinata essential oil for 360 days at two different temperatures. The essential oil was distilled from dried leaves of seven-month-old plants using the hydrodistillation method, and the chemical composition was determined using GC-MS and GC/FID. The effects of storage on the essential oil Hyptis pectinata were tested over the course of a year (0, 15, 30, 60, 90, 120, 150, 180, 240, 300, and 360 days), using two temperatures: room (±32ºC) and freezer (-20ºC). The predominant compounds in the essential oil are β-caryophyllene, caryophyllene oxide, and germancrene D. The concentration of the chemical constituents of the essential oil varied depending on the storage temperature, and over the 360 days. The storage of the essential oil at room temperature over one year resulted in higher concentrations of β-elemene, α-copaene, germacrene D, caryophyllene oxide, and (E,E)-α-farnesene and lower content of α-humulene and β-caryophyllene, compared to the results obtained from storing the essential oil in a freezer. These results indicate that the essential oil should be stored in a freezer, which provides greater stability to the concentration of the chemical constituents.Keywords: aromatic and medicinal plant, post-harvest, sambacaitá, chemical constituents.RESUMO: Influência do tempo de armazenamento e da temperatura na composição química do óleo essencial de Hyptis pectinata L. Poit. Hyptis pectinata, conhecida popularmente como Sambacaitá é uma erva medicinal nativa utilizada pela população local para o tratamento de enfermidades, cujas propriedades farmacológicas, antimicrobianas e medicinais foram relatadas em diversos estudos. O óleo essencial das folhas é rico em compostos terpênicos responsáveis pelas suas propriedades. Devido à existência de fatores que podem influenciar a composição química dos óleos essenciais, o objetivo deste trabalho foi avaliar a influência do armazenamento do óleo essencial Hyptis pectinata durante 360 dias em duas temperaturas diferentes. O óleo essencial foi destilado a partir de folhas secas de plantas de sete meses de idade, utilizando o método de hidrodestilação e a composição química foi determinada usando CG-EM e CG-DIC. Os efeitos do armazenamento no óleo essencial Hyptis pectinata foram testados ao longo de um ano (0, 15, 30, 60, 90, 120, 150, 180, 240, 300 e 360 dias), utilizando duas temperaturas: ambiente (±32ºC) e freezer (-20ºC). Os compostos predominantes no óleo essencial foram o β-cariofileno, óxido de cariofileno e germancreno D e houve variação na concentração dos constituintes químic...

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LASSBio‐1829 Hydrochloride: Development of a New Orally Active N‐Acylhydrazone IKK2 Inhibitor with Anti‐inflammatory Properties

Guedes

Freitas

Cordeiro³

et al. 2015

ChemMedChem

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Inhibitor of nuclear factor κB kinase 2 (IKK2) is suggested to be a potential target for the development of novel anti-inflammatory and anticancer drugs. In this work, we applied structure-based drug design to improve the potency of the inhibitor (E)-N'-(4-nitrobenzylidene)-2-naphthohydrazide (LASSBio-1524, 1 a: IC50 =20 μm). The molecular model built for IKK2 together with the docking methodology employed were able to provide important and consistent information with respect to the structural and chemical inhibitor characteristics that may confer potency to IKK2 inhibitors, providing important guidelines for the development of a new N-acylhydrazone (NAH) derivative. (E)-N'-(4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzylidene)-2-naphthohydrazide hydrochloride (LASSBio-1829 hydrochloride, 10) is a 7-azaindole NAH able to inhibit IKK2 with an IC50 value of 3.8 μm. LASSBio-1829 hydrochloride was found to be active in several pharmacological inflammation tests in vivo, showing its potential as an anti-inflammatory prototype.

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Characterisation of the anti-inflammatory and antinociceptive activities of the Hyptis pectinata (L.) Poit essential oil

Cited by 80 publications

References 39 publications

Influence of Drying in Hyptis pectinata Essential Oil

Influence of Drying in Hyptis pectinata Essential Oil

Influence of storage time and temperature on the chemical composition of the essential oil of Hyptis pectinata L. Poit

LASSBio‐1829 Hydrochloride: Development of a New Orally Active N‐Acylhydrazone IKK2 Inhibitor with Anti‐inflammatory Properties

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