Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology

D’Agostino, Maurine; Tesse, Nicolas; Lavergne, Rose Anne; Pape, Patrice Le; Bouchara, Jean Philippe; Frippiat, Jean-Pol; Machouart, Marie; Debourgogne, Anne

doi:10.1016/j.jgar.2021.03.017

Cited by 4 publications

(11 citation statements)

References 29 publications

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“…However, there was a significant difference between MTR and wild-type (WT) strains of Aspergillus fumigatus to VRC. The average MIC for susceptible strains was 1 µg ml −1 , while it was 8 or 16 µg ml −1 for A. fumigatus TR 34 and TR 46 , respectively, indicating a dilution rank greater ≥2 [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…In a previous study we demonstrated that the distribution of MIC for CIN-102 was unimodal for Fusarium , Scedosporium and Aspergillus genera, with a small range of MIC values, unlike voriconazole and amphotericin B (3–4 dilution range of MIC for CIN-102). These results indicate that these strains did not develop resistance against CIN-102 [ 16 ]. We also demonstrated that CIN-102 is equally effective against both susceptible and resistant strains, unlike VRC and AMB.…”

Section: Discussionmentioning

confidence: 99%

“…The Septeos company has developed CIN-102, a synthetic mixture of seven compounds comprising three cinnamaldehyde derivatives, that was developed from the formulation of cinnamon essential oil available in the Pharmacopoeia, and from which the genotoxic compounds (safrole, eugenol and coumarin) have been removed. The compounds in this mixture are synergic, and exhibit fungicidal antifungal activity on the genera Aspergillus , Fusarium and Scedosporium [ 16 ]. Consequently, this study aimed to determine the effect of this new compound on the resistance phenotypes of strains involved in IFIs, on biofilm formation, and on induced resistance.…”

Section: Introductionmentioning

confidence: 99%

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In vitro antifungal effect of a plant-based product, CIN-102, on antifungal resistant filamentous fungi and their biofilms

D’Agostino

Tesse

Lavergne

et al. 2021

Journal of Medical Microbiology

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Introduction. The increase of invasive fungal infections (IFIs) and associated treatment failure in populations at risk is driving us to look for new treatments. Hypothesis. The CIN-102 compound, derived from cinnamon essential oil, could be a new antifungal class with an activity, in particular, on strains resistant to current antifungals but also on biofilms, a factor of virulence and resistance of fungi. Aim. The aim of this study is to show the activity of CIN-102 on various strains resistant to current antifungals, on the biofilm and to determine the possibility of resistance induced with this compound. Methodology. We studied the MIC of CIN-102 and of current antifungals (voriconazole and amphotericin B) using CLSI techniques against eight different strains of three genera of filamentous fungi involved in IFIs and having resistance phenotypes to current antifungals. We also determined their effects on biofilm formation, and the induced resistance by voriconazole (VRC) and CIN-102. Results. MIC values determined for CIN-102 were between 62.5 and 250 µg ml−1. We demonstrated the antifungal effect of CIN-102 on biofilm, and more particularly on its formation, with 100 % inhibition achieved for most of the strains. CIN-102 at a sub-inhibitory concentration in the medium did not induce resistance in our strains, even after 30 generations. Conclusions. In this study we show that CIN-102 is effective against resistant filamentous fungi and against biofilm formation. In addition, our strains did not acquire a resistance phenotype against CIN-102 over time, unlike with VRC. CIN-102 is therefore an interesting candidate for the treatment of IFIs, including in cases of therapeutic failure linked to resistance, although further studies on its efficacy, safety and mechanism of action are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro antifungal effect of a plant-based product, CIN-102, on antifungal resistant filamentous fungi and their biofilms

D’Agostino

Tesse

Lavergne

et al. 2021

Journal of Medical Microbiology

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“…The main antifungal ingredient of Cinnamomum cassia is cinnamaldehyde [18,21,22]. Other varieties of cinnamon based EOs exist, such as Cinnamomum zeylanicum (bark), which also contains cinnamaldehyde.…”

Section: Discussionmentioning

confidence: 99%

“…All five EOs tested here are known for their antifungal activity against at least some members of the genus Aspergillus [14][15][16][17][18]21,22]. However, to our knowledge, no past study has assessed the effect of these EOs against A. oryzae specifically.…”

Section: Cinnamomum Cassia a Fungicidal Eo Against A Oryzaementioning

confidence: 99%

Antifungal activity of Cinnamomum cassia and Origanum compactum essential oils against Aspergillus oryzae

Leclercq

Commenge

Bouriot

et al. 2022

Preprint

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Aspergillosis is a nosocomial disease that usually affects the respiratory system. While most patients develop mild symptoms, aspergillosis can become a serious health threat in immunocompromised populations and patients with pre-existing respiratory conditions. Aspergillosis is caused by fungi of the Aspergillus genus. Existing treatments include drugs such as amphotericin B, with strong side effects. Numerous studies have shown the antifungal properties of essential oils (EOs), which represent potential alternative treatments against fungal infections. Here, we screened the antifungal properties of five EOs against Aspergillus oryzae: Melaleuca alternifolia, Mentha x piperita, Thymus zygis, Origanum compactum, and Cinnamomum cassia. Of the five EOs, two demonstrated antifungal activity: Origanum compactum acted as a fungistatic, while Cinnamomum cassia showed both fungistatic and fungicidal effects against A. oryzae. Therefore, both EOs represent potential alternative treatments against Aspergillosis.

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Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis

Leclercq,

Commenge,

Bouriot

et al. 2024

MSURJ

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Aspergillosis is a disease that usually affects the respiratory system. While most patients develop mild symptoms, aspergillosis can become a serious health threat in immunocompromised populations and patients with pre-existing respiratory conditions. Aspergillosis is caused by fungi of the Aspergillus genus. Existing treatments include drugs such as azoles, ergosterol interfering agents (Amphotericin B), and echinocandins (Caspofungin), which usually come with various drawbacks. Numerous studies have shown the antifungal properties of certain essential oils (EOs), which represent potential alternative treatments against fungal infections. Here, we screened the antifungal properties of five EOs against Aspergillus oryzae: Melaleuca alternifolia, Mentha x piperita, Thymus zygis, Origanum compactum, and Cinnamomum cassia. Of the five EOs, two demonstrated antifungal activity: Origanum compactum acted as a fungistatic, while Cinnamomum cassia showed both fungistatic and fungicidal effects against A. oryzae. Therefore, both EOs represent potential alternative treatments against Aspergillosis.

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Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology

Cited by 4 publications

References 29 publications

In vitro antifungal effect of a plant-based product, CIN-102, on antifungal resistant filamentous fungi and their biofilms

In vitro antifungal effect of a plant-based product, CIN-102, on antifungal resistant filamentous fungi and their biofilms

Antifungal activity of Cinnamomum cassia and Origanum compactum essential oils against Aspergillus oryzae

Cinnamomum cassia and Origanum compactum Essential Oils as Antifungal Candidates for the Treatment of Aspergillosis

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