Characterisation of the correlations between oxidative potential and in vitro biological effects of PM10 at three sites in the central Mediterranean

Guascito, Maria Rachele; Lionetto, Maria Giulia; Mazzotta, Franco; Conte, M.; Giordano, Maria Elena; Caricato, Roberto; Bartolomeo, Anna Rita De; Dinoi, Adelaide; Cesari, Daniela; Merico, Eva; Mazzotta, Laura; Contini, Daniele

doi:10.1016/j.jhazmat.2023.130872

Cited by 39 publications

(22 citation statements)

References 92 publications

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“…Moderate to high correlations (e.g., often in the range of 0.44 to 0.75) between OP v DTT and PM mass concentration have been reported in ambient (outdoor air) studies. 48 , 75 , 76 These findings, along with the considerable variability in OP m DTT for the indoor experiments, suggest that the PM 2.5 mass concentration may not adequately represent the relative adverse health responses from exposures to different indoor sources.…”

Section: Resultsmentioning

confidence: 96%

“…The two data points significantly deviating from the regression line with relatively high OP v DTT values in Figure a correspond to emissions from the pellet stove, indicating heightened toxicity. Moderate to high correlations (e.g., often in the range of 0.44 to 0.75) between OP v DTT and PM mass concentration have been reported in ambient (outdoor air) studies. ,, These findings, along with the considerable variability in OP m DTT for the indoor experiments, suggest that the PM 2.5 mass concentration may not adequately represent the relative adverse health responses from exposures to different indoor sources.…”

Section: Resultsmentioning

confidence: 97%

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Indoor–Outdoor Oxidative Potential of PM_2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Yang,

Battaglia,

Robinson

et al. 2024

ACS EST Air

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The indoor air quality of a residential home during winter in Fairbanks, Alaska, was investigated and contrasted with outdoor levels. Twenty-four-hour average indoor and outdoor filter samples were collected from January 17 to February 25, 2022, in a residential area with high outdoor PM 2.5 concentrations. The oxidative potential of PM 2.5 was determined using the dithiothreitol-depletion assay (OP DTT ). For the unoccupied house, the background indoor-to-outdoor (I/O) ratio of massnormalized OP (OP m DTT ), a measure of the intrinsic healthrelevant properties of the aerosol, was less than 1 (0.53 ± 0.37), implying a loss of aerosol toxicity as air was transported indoors. This may result from transport and volatility losses driven by the large gradients in temperature (average outdoor temperature of −19°C/average indoor temperature of 21 °C) or relative humidity (average outdoor RH of 78%/average indoor RH of 11%), or both. Various indoor activities, including pellet stove use, simple cooking experiments, incense burning, and mixtures of these activities, were conducted. The experiments produced PM 2.5 with a highly variable OP m DTT . PM 2.5 from cooking emissions had the lowest OP values, while pellet stove PM 2.5 had the highest. Correlations between volume-normalized OP DTT (OP v DTT ), relevant to exposure, and indoor PM 2.5 mass concentration during experiments were much lower compared to those in outdoor environments. This suggests that mass concentration alone can be a poor indicator of possible adverse effects of various indoor emissions. These findings highlight the importance of considering both the quantity of particles and sources (chemical composition), as health metrics for indoor air quality.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 97%

Indoor–Outdoor Oxidative Potential of PM_2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Yang,

Battaglia,

Robinson

et al. 2024

ACS EST Air

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“…For example, Chirizzi et al 17 estimated a higher oxidative potential in PM2.5 that originated from road traffic and biomass combustion sources compared to Saharan dust particles, and attributed this outcome to the high carbon content at the specific site. Guascito et al 18 found that both cellular and intracellular oxidative stress indicators are strongly influenced by combustion sources. Grange et al 19 clearly identified that road traffic and carbonaceous wood combustion sources had the greatest mass-normalized oxidative potential, and was clearly the most potent source of PM2.5 in Switzerland.…”

Section: Introductionmentioning

confidence: 99%

Health effects of carbonaceous PM2.5 compounds from residential fuel combustion and road transport in Europe

Paisi,

Kushta,

Pozzer

et al. 2024

Sci Rep

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Exposure to fine particulate matter (PM2.5) is associated with an increased risk of morbidity and mortality. In Europe, residential fuel combustion and road transport emissions contribute significantly to PM2.5. Toxicological studies indicate that PM2.5 from these sources is relatively more hazardous, owing to its high content of black and organic carbon. Here, we study the contribution of the emissions from these sectors to long-term exposure and excess mortality in Europe. We quantified the impact of anthropogenic carbonaceous aerosols on excess mortality and performed a sensitivity analysis assuming that they are twice as toxic as inorganic particles. We find that total PM2.5 from residential combustion leads to 72,000 (95% confidence interval: 48,000–99,000) excess deaths per year, with about 40% attributed to carbonaceous aerosols. Similarly, road transport leads to about 35,000 (CI 23,000–47,000) excess deaths per year, with 6000 (CI 4000–9000) due to carbonaceous particles. Assuming that carbonaceous aerosols are twice as toxic as other PM2.5 components, they contribute 80% and 37%, respectively, to residential fuel combustion and road transport-related deaths. We uncover robust national variations in the contribution of each sector to excess mortality and emphasize the importance of country-specific emission reduction policies based on national characteristics and sectoral shares.

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“…The oxidative potential (OP) is a measure of the capacity of PM to oxidize target molecules and is considered a better metric of PM toxicity than PM mass alone (Calas et al 2018;Molina et al 2020). Recent works have shown that cytotoxic and ecotoxic effects measured using in vitro tests depend on PM chemical composition rather than on mass concentrations, and that cytotoxicity is correlated with acellular OP measurements, although the strength of the correlation may display seasonal and site-to-site variations (Guascito et al 2023;Lionetto et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of PM10 oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements

Clemente

Gil-Moltó

Yubero

et al. 2023

Air Qual Atmos Health

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The oxidative potential (OP) of PM10 daily samples collected at a traffic site in southeastern Spain during summer and winter was assessed by two acellular assays: the ascorbic acid (AA) and dithiothreitol (DTT) methods. Although PM10 levels were similar during both periods, OP values (expressed in nmol min−1 m−3) showed a defined seasonal trend. The AA activity was higher in summer than in winter, whereas the DTT reactivity exhibited an opposite seasonal pattern. Both assays were sensitive to different PM10 components, as shown by the results of the linear correlation analysis. Moreover, the relationship between OP values and PM10 chemical species was not the same during summer and winter, indicating that particle toxicity is associated with different sources during the warm and cold seasons. When OP values were expressed on a mass basis (nmol min−1 µg−1), lower correlation coefficients with PM10 chemical species were generally obtained compared to volume-normalized activities. These outcomes suggest that only some specific components have a significant intrinsic oxidative potential.

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Characterisation of the correlations between oxidative potential and in vitro biological effects of PM10 at three sites in the central Mediterranean

Cited by 39 publications

References 92 publications

Indoor–Outdoor Oxidative Potential of PM_2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Indoor–Outdoor Oxidative Potential of PM_2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Health effects of carbonaceous PM2.5 compounds from residential fuel combustion and road transport in Europe

Sensitivity of PM10 oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements

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Characterisation of the correlations between oxidative potential and in vitro biological effects of PM10 at three sites in the central Mediterranean

Cited by 39 publications

References 92 publications

Indoor–Outdoor Oxidative Potential of PM2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Indoor–Outdoor Oxidative Potential of PM2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Health effects of carbonaceous PM2.5 compounds from residential fuel combustion and road transport in Europe

Sensitivity of PM10 oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements

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Product

Resources

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Indoor–Outdoor Oxidative Potential of PM_2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities

Indoor–Outdoor Oxidative Potential of PM_2.5 in Wintertime Fairbanks, Alaska: Impact of Air Infiltration and Indoor Activities