Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging

Tessier, Jean; Bowyer, Jonathan; Brownrigg, N J; Peers, Ian; Westwood, F. Russell; Waterton, John C.; Maciewicz, Rose A.

doi:10.1016/s1063-4584(03)00162-6

Cited by 72 publications

(74 citation statements)

References 22 publications

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“…To date, MRI tomographic knowledge of rodent joint anatomy and pathology is limited (Tessier et al 2003, Wang & Westwood 2006. Indeed, knowledge accumulated for human clinical MRI has been translated into understanding of MRI of animal joints (Banfield & Morrison 2000).…”

Section: Discussionmentioning

confidence: 99%

Some aspects of rat femorotibial joint microanatomy as demonstrated by high-resolution magnetic resonance imaging

et al. 2006

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SummaryHigh-resolution magnetic resonance images (MRI) of the right femorotibial joint of normal Han:Wistar rats were acquired using a 4.7 Tesla magnet and a single-turn solenoid radio frequency coil (built in-house). Some anatomical findings of the rat femorotibial joint, which have not been reported previously using MRI, are described. The separation of patellar ligament and crural fascia was feasible on MRI. This separation would not be seen on images of lower resolution and its presence on high-resolution images could be mistaken for artefact due to the magic angle effect. Band-like fibrous structures exist in the infra-patellar fat pad, which might be mistaken as ligaments within the femorotibial joint. On sagittal MRI a vessel was seen inserted on the central part of the caudal surface of the patellar ligament. Subcutaneous fascia/cutaneous muscles (panniculus carnosus) could also be demonstrated with MRI in the femorotibial joint area.

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Section: Discussionmentioning

confidence: 99%

Some aspects of rat femorotibial joint microanatomy as demonstrated by high-resolution magnetic resonance imaging

et al. 2006

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“…These phases have been demonstrated in experimental animal models by sequential MR imaging (Gahunia et al 1995, Watson et al 1996a, Tessier et al 2003). Although cartilage represents a thin layer of material relative to the size of the voxels that are typically used for MR imaging, cartilage thickness and volume have been quantified at multiple points in animals as small as guineapigs and rabbits.…”

Section: Interpretation Of Knee Joint Mr Imagesmentioning

confidence: 96%

“…Chemical shift artefacts are due to the protons in fat being mis-mapped relative to water protons ( Figure 6). Susceptibility artefacts occur at the interfaces of structures with different magnetic susceptibilities (Figure 7, Tessier et al 2003). In some surgically-induced OA animal models, the metal debris remaining in the tissue after surgery can cause significant artefacts and distort the images.…”

Section: Imaging Artefactsmentioning

confidence: 99%

“…For example, human knee menisci appear as a dark signal on conventional MR sequences, and increased signal within menisci indicates degeneration or tear. However, with small animals, such as guineapigs and rats, parts of a normal meniscus can appear as an intermediate to bright signal (Figures 7 and 8), a dark signal within meniscus may indicate ossification (Figure 7) (Tessier et al 2003). Another example is that in the epiphysis of both femur and tibia, there are normal notches that could be interpreted as destruction or cysts (Figure 9).…”

Section: Interpretation Of Knee Joint Mr Imagesmentioning

confidence: 99%

“…Magnetic resonance (MR) imaging has already been applied to investigate a variety of OA animal models, including mouse (Munasinghe et al 1995), rat (Wang et al 2005, Wang et al 2006c, guineapig (Watson et al 1996b, Tessier et al 2003, rabbit (Calvo et al 2001, Laurent et al 2003, monkey (Gahunia et al 1995), goat (Laurent et al 2006) and dog (Libicher et al 2005). MR imaging can non-invasively provide detailed images of joints displaying cartilage, skin, synovial cavity, muscle and bones (Wang et al 2006a).…”

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In vivo magnetic resonance imaging of animal models of knee osteoarthritis

Wáng

2008

Lab Anim

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SummaryRecent technical developments in high-field magnetic resonance (MR) scanners, improvement in radio frequency coil design and gradient performance along with the development of efficient pulse sequences and new methods of enhancing contrast have made high-quality imaging of animal arthritis models feasible. MR can provide high-resolution structural information about the osteoarthritic changes in animal models, and also information about the biophysical properties of cartilage. This paper reviews the MR techniques available for animal knee imaging, and the various MR-derived readouts of knee osteoarthritis in animal models. Pitfalls in interpreting animal joint anatomy and joint composition are highlighted.

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Natural History of Knee Cartilage Defects and Factors Affecting Change

Ding¹,

Cicuttini²,

Scott³

et al. 2006

Arch Intern Med

152

162

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Background: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history.Methods: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later.Results: Thirty-three percent of the subjects had a worsening (Ն1-point increase) and 37% of the subjects had an improvement (Ն1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment).Conclusions: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.

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Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging

Cited by 72 publications

References 22 publications

Some aspects of rat femorotibial joint microanatomy as demonstrated by high-resolution magnetic resonance imaging

Some aspects of rat femorotibial joint microanatomy as demonstrated by high-resolution magnetic resonance imaging

In vivo magnetic resonance imaging of animal models of knee osteoarthritis

Natural History of Knee Cartilage Defects and Factors Affecting Change

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