Characterisation of time-independent and time-dependent rheological behaviour simultaneously by multiple loop experimentation

Shanthilal, J.; Bhattacharya, Suvendu

doi:10.1007/s13197-016-2360-3

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…On the other hand, the flow behaviours of non-Newtonian fluids are influenced by the applied shear rate [133]. Fluids that portray time-dependant flow behaviour changes are thixotropic-and rheopexy fluids, whereas time-independent flow-induced changes are observed in fluids of pseudo-plastic, dilatant-, and visco-elastic natures [133,134]. Pseudo-plastic flow behaviour is also termed shear-thinning and is considered the most favourable flow behaviour of non-Newtonian fluids destined for topical application since these fluids are known to show decreased viscosity once subjected to increased shear rates, as is the case with rubbing during topical application.…”

Section: Viscositymentioning

confidence: 99%

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

2020

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Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented by these uniquely simplified systems in terms of muco-adhesiveness and zeta-potential changing capacity lead the way forward to ground-breaking research. Contrarily, SEDDSs destined for topical/transdermal drug delivery have received limited attention. Therefore, this review is focused at utilising principles, established during development of oral SEDDSs, and tailoring them to fit evaluation strategies for an optimised topical/transdermal drug delivery vehicle. This includes a detailed discussion of how the authentic pseudo-ternary phase diagram is employed to predict phase behaviour to find the self-emulsification region most suitable for formulating topical/transdermal SEDDSs. Additionally, special attention is given to the manner of characterising oral SEDDSs compared to topical/transdermal SEDDSs, since absorption within the gastrointestinal tract and the multi-layered nature of the skin are two completely diverse drug delivery territories. Despite the advantages of the topical/transdermal drug administration route, certain challenges such as the relatively undiscovered field of skin metabolomics as well as the obstacles of choosing excipients wisely to establish skin penetration enhancement might prevail. Therefore, development of topical/transdermal SEDDSs might be more complicated than expected.

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Section: Viscositymentioning

confidence: 99%

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

2020

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“…Categorised into saturated fatty acids (stearic and palmitic), unsaturated fatty acids (Linoleic, linolenic and oleic) and polyunsaturated fatty acids. Vegetable oils have high composition of saturated and unsaturated fatty acid which sums up to almost 80% of the oil composition (Shanthilal & Bhattacharya, 2016). However, the FFA composition is not altered during the trans-esterification of oils to produce biodiesel.…”

Section: Free Fatty Acidsmentioning

confidence: 99%

“…Models selected to investigate the correlation among the parameters were Bingham, Herschel-Bulkley, Newton, and Oswald De Waele, also known as the Power-law model. On the account of time independent characteristic observed from the studied samples the rheological models were selected to represent the flow behaviour of the samples (Mezger, 2020;Shanthilal & Bhattacharya, 2016). Mathematical expressions 12-15 display the parameters of the respective rheological models are:…”

Section: Determination Of Rheological Models Describing the Flow Beha...mentioning

confidence: 99%

Rheological and physicochemical analysis of non- edible oils used for biodiesel production

Zakaria

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The knowledge of the physicochemical and rheological flow characteristics of biodiesel feedstock is used for quality control in production, storage and transportation processes. Moreover, the knowledge is applied in redesigning and optimizing facilities that can be used for manufacturing, storage and transportation of the fuel. Non-edible oils analysed in the present study were Cashew Nut Shell Liquid (CNSL), Castor Oil (CO), croton megalocarpus oil (CMO), podocarpus usambarensis oil (PUO) and Thevetia peruviana oil (TPO). Free fatty acid, acid value, saponification value, peroxide value, iodine value, specific gravity and moisture content were determined by following the recommended Association of Official Analytical Chemists (AOAC) methods of analysing physicochemical characteristics. Physicochemical results show that all the selected non-edible vegetable oils with an exception of CNSL, do not require any further treatment. However, due to high Free Fatty Acid (FFA) content in CNSL, direct biodiesel production from the feedstock would be a challenge hence further treatment to reduce the acidity of the feedstock is essential. Rheological flow parameters were analysed using VT-550 Thermo Haake Viscotester monitored by a Rheowin Job manager. The pre-set parameters in the Viscotester were the shear rate and temperature. The shear rate was increased uniformly from 5 𝑠−1 –100 𝑠−1 in 60 seconds at 30-60˚C. Regardless of the analysis temperature, all oils exhibited Newtonian flow behavior, indicating that the viscosity of the oil remained uniform at a constant temperature. The experimental data were fitted into rheological models: Newton, Bingham, Oswald de Waele (power-law), and Herschel Bulkley using Rheowin data evaluation software. The results revealed that Newton and Oswald de Waele models were appropriate to represent the flow behaviour of the oils with the fit of R2 ≥ 0.990.

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Technological and sensorial properties of liquid nitrogen ice cream enriched with protein from brewing waste (trub)

Saraiva

Silva

Anjo

et al. 2019

Int J of Food Sci Tech

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Debittered trub (brewing waste) is an important source of protein source (70.26%). Trub and whey protein were used for 5% protein enrichment of ice cream frozen by liquid nitrogen. Three formulations were elaborated: ice cream standard (ICS), ice cream with whey protein (ICW) and ice cream with trub (ICT). Chemical composition, rheological properties, texture, overrun, melting rate, scanning electron microscopy and a sensorial test were performed. Results showed that ICT presented a higher viscosity, obtained on the upward curve up to 6.76 Pa s−1, consistency index (22.96 (Pa s−1)n), hysteresis area (140.40 mPa s−1) and hardness (31113.33 g) but a lower melting rate (0.38 g min−1), overrun (13.92%) and sensorial acceptability than the other formulations. The addition of trub debittered for protein enrichment improved ice cream properties and demonstrated that it could be used as a food ingredient.

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Characterisation of time-independent and time-dependent rheological behaviour simultaneously by multiple loop experimentation

Cited by 3 publications

References 10 publications

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

Rheological and physicochemical analysis of non- edible oils used for biodiesel production

Technological and sensorial properties of liquid nitrogen ice cream enriched with protein from brewing waste (trub)

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