The article presents the results of studies conducted in 2011-2016 years on the southern chernozem in the southern Steppe of Ukraine, studied the efficiency of processing winter wheat crops modern growth-regulating drugs in the main periods of vegetation of the crop on the background of mineral fertilizers application. It was determined that the introduction of pre-sowing cultivation of winter wheat fertilizer in a dose of N 30 P 30 (background) and the use of foliar fertilizing of crops at the beginning of the resumption of spring vegetation and the beginning of stooling complex organic fertilizers Organic D2 and Escort-bio created favorable conditions for the formation of optimal indicators of the structure of the crop and, accordingly, a high level of grain yield of the studied varieties. In the variants of fertilizer Organic D2 and Escort-bio plants of winter wheat variety Kolchuga formed 4,42-4,48 t / ha of grain, and plants of Zamozhnist formed 4,96-4,99 t/ha, which exceeded the control by 52,9-55,0 and 62,6-63,6%, respectively. From the studied varieties of winter wheat on a set of indicators, it was determined Zamozhnist as the best variety.