Study Need and Importance: Patient and clinical factors are the most commonly identified variables associated with hospital readmission after radical cystectomy, but other factors may be important drivers of outcomes, such as hospital and physician characteristics. This study investigates the contribution of patient, physician, and hospital factors on hospital readmission after radical cystectomy. What We Found: Of 3,530 patients analyzed within the Surveillance Epidemiology, and End ResultsÀMedicare database, 1,291 (36.6%) were readmitted within 90 days of the index surgery. Complications were more frequent in the readmission cohort (89.0% vs 55.2%, P < .001). On multilevel multivariable analysis, factors significantly associated with readmission included continent urinary diversion (OR 1.55, 95% CI 1.21, 2.00), greater National Cancer Institute comorbidity index (2-<4 vs 0-<2, OR 1.35, 95% CI 1.05, 1.75; 4D vs 0-<2, OR 1.76, 95% CI 1.20, 2.58), American Joint Committee on Cancer stage (P [ .04), and hospital region (P [ .05). Neither hospital volume, physician volume, teaching hospital status, nor National Cancer Institute center designation was associated with hospital readmission. The main source of UROLOGY PRACTICE Ò Ó 2022 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.