2015
DOI: 10.1136/lupus-2015-000112
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Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-responders

Abstract: IntroductionThe kidney biopsy is used to diagnose and guide initial therapy in patients with lupus nephritis (LN). Kidney histology does not correlate well with clinical measurements of kidney injury or predict how patients will respond to standard-of-care immunosuppression. We postulated that the gene expression profile of kidney tissue at the time of biopsy may differentiate patients who will from those who will not respond to treatment.MethodsThe expression of 511 immune-response genes was measured in kidne… Show more

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Cited by 41 publications
(25 citation statements)
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“…IRF1 is a transcription factor that is activated by type I IFN signaling and is important for development of (32), and prediction of treatment response in lupus nephritis(33). Importantly, IRF1 has been identified as a central regulator of target genes in lupus monocytes(34) and has been reported as a transcription factor of caspase-1(35, 36).…”
Section: Resultsmentioning
confidence: 99%
“…IRF1 is a transcription factor that is activated by type I IFN signaling and is important for development of (32), and prediction of treatment response in lupus nephritis(33). Importantly, IRF1 has been identified as a central regulator of target genes in lupus monocytes(34) and has been reported as a transcription factor of caspase-1(35, 36).…”
Section: Resultsmentioning
confidence: 99%
“…The complete protocol for RNA isolation and analysis was previously described (6). In brief, formalin-fixed and paraffin-embedded (FFPE) kidney biopsy tissue blocks were sectioned.…”
Section: Methodsmentioning
confidence: 99%
“…Pathway analysis was done as described previously (6). In brief, pathway analysis was conducted using less stringent criteria than those used to identify differentially expressed genes.…”
Section: Methodsmentioning
confidence: 99%
“…The applicability of molecular analyses of the kidney biopsy to LN treatment is illustrated by a recent survey of transcript expression of immune genes in kidney biopsies done at LN flare. Patients who had early complete clinical renal responses to standardof-care induction therapies could be distinguished from nonresponders on the basis of transcript expression profiles (56). A similar approach could conceivably be applied to patients being treated with novel therapies to define which patients are likely to respond to a particular treatment.…”
Section: The Kidney Biopsy In Lnmentioning
confidence: 99%