Depending on rock pore compressibility, a change in effective confining pressure (ECP) can have a significant influence on supercritical CO 2 (SC-CO 2) migration characteristics in natural reservoirs. In this study, a tight glutenite sample was used to conduct porosity/permeability measurements under different ECPs of 1.5, 5.5, 9.5, 13.5, 17.5 and 21.5 MPa. Then a SC-CO 2 drainage core flooding experiment, which was monitored using nuclear magnetic resonance (NMR) technique, was conducted at an ECP of 5.5 MPa. Measurement results show that the porosity and permeability of the sample were comparatively low (at an ECP of 1.5 MPa, 8.3% and 2.4 mD, respectively). With increasing ECP, the porosity/permeability decreased rapidly initially then more slowly at the larger ECP value. NMR results shows that SC-CO 2 preferentially displaced water creating flow channels inside the sample. At SC-CO 2 breakthrough, the average residual water saturation was 69.86%. Following breakthrough, SC-CO 2 continued to displace the water creating more substantial flow channels until they were sufficient to transport the SC-CO 2 at the fixed flow rate, resulting in a residual water saturation of 42.72%. A two-dimensional computational model was then established based on these experimental results to simulate the fluid behaviors at an ECP of 5.5 MPa, and then the model was