Characteristic Appearances of Peripheral Schwannoma on High-Resolution Ultrasonography And MRI: Comparison Between Antoni A-Dominant and Antoni B-Dominant Types

Fujioka, Kazumi

doi:10.26717/bjstr.2020.32.005221

Cited by 3 publications

(6 citation statements)

References 34 publications

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“…One of the problems in differentiating peripheral nerve tumors is that imaging findings of schwannomas, neurofibromas, and other neurogenic tumors are very similar, including the “target sign.” A recent study by Ogata et al (14) (24 patients, 11 schwannomas, and 13 other peripheral tumors) and review by Fujioka (15) both explored the potential of US in differential diagnosis of schwannomas. Authors reported the “target sign” among important but rare findings, consistent with the presence of hypercellular Antoni A areas in the center and myxoid Antoni B areas in the periphery (15). Although sonoelastography is a known tool for differentiating between benign and malignant peripheral soft-tissue lesions (22), its application in the diagnosis of benign tumors is limited.…”

Section: Discussionmentioning

confidence: 99%

“…The target sign was reported in 4.9% of non-schwannoma cases, but only in 2D imaging, suggesting that the target sign of schwannomas is more sensitive on elastography. Histological examination shows a hypercellular center and a hypocellular periphery rich in marcrophages and collagen fibers (15). The differences in internal compositions of schwannomas can be observed on elastography but less obvious on 2D images.…”

Section: Discussionmentioning

confidence: 99%

“…It is noted that US provides excellent information for the initial assessment, but problems in differentiating between subcutaneous schwannomas and other subcutaneous tumors may arise (14). A recent review by Fujioka (15) in 2020 reported signs of distinction between Antoni A-dominant and Antoni B-dominant schwannoma types and suggested high-resolution US as one of the diagnostic techniques of choice along with color Doppler US.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

et al. 2022

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Background Ultrasound (US) diagnostic techniques have the advantages of low cost, convenient operation, and high availability. Purpose To explore the diagnostic accuracy of multiparametric US in evaluating signs of peripheral schwannoma. Material and Methods This retrospective case-control study included patients with soft-tissue masses on the limbs (divided into the schwannoma and non-schwannoma groups) between January 2017 and November 2020. US features were compared between the two groups, and receiver operating characteristics analysis was used to evaluate the diagnostic efficacy of these features. Results A total of 165 patients were included in this study; of them, 63 (38.2%) were diagnosed with schwannoma. Regular morphology (95.2% vs. 39.2%), cystic degeneration (71.4% vs. 27.5%), target sign on elastography (82.5% vs. 0), and polar blood supply sign (87.3% vs. 14.7%) were more common in schwannomas than in non-schwannoma lesions (all P < 0.001). Combining the four signs for diagnosis of schwannomas, the sensitivity, specificity, and accuracy were 95.24%, 96.08%, and 95.76%, respectively, with an area under the curve (AUC) of 0.987 (95% confidence interval = 0.955–0.998). Entering and exiting nerve sign was observed in 87.3% of schwannomas and in 3.0% of non-schwannoma lesions ( P < 0.001), while split-fat sign was similar between the two groups (9.5% vs. 2.0%; P = 0.068). Conclusion Polar blood supply sign and target sign on elastography are specific US signs in peripheral schwannomas. The combination of two-dimensional imaging, color flow imaging, and elastography can achieve an excellent diagnostic accuracy in schwannomas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

et al. 2022

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“…Recently, the study using the ultra-highfrequency ultrasound in the evaluation of pediatric pilomatricoma has been reported [11]. The author usually performs US studies for dermatologic fields with a high-resolution, broad-band (5MHz-18MHz) linear transducer (Nobulus Hitachi, Ltd.Tokyo, Japan) and described several reports in the dermatologic area [2,4,5,[12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Ultrasound In Dermatologymentioning

confidence: 99%

Acral Calcified Angioleiomyoma Along with Radiological Features

Fujioka

2021

BJSTR

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Angioleiomyoma (ALM) is a rare benign, vascular smooth muscle tumor originating from the tunica media of the vessel wall. It typically arises in the cutaneous, subcutaneous tissue of the lower extremities in middle-aged women. The author has previously described the solid subtype of ALM as a painful and vascularized subcutaneous tumor and indicated that all painful cutaneous and subcutaneous tumors used as the acronym "ENGLAND" or "LEND an EGG" show vascularized appearances on high-resolution color Doppler ultrasonography (US). Whereas ALMs of the fingers, toes, hands, and fee as acral type, namely acral calcified ALMs are rarely found. Kacerovska et al. mentioned that the lesion was pathologically composed of mature smooth muscle cells and vascular pattern accompanied with the prominent calcifications. In this article, the current knowledges of the acral calcified ALM have been reviewed in detail. Based on the evidence, acral calcified ALM pathologically shows the changes including calcification, sometimes extensive calcification hyalinization, and bleeding. Similar to the ordinary ALM, it is putative that acral calcified ALM also tends to represent painful and pathologically vascularized tumor. In addition to the characteristic manifestation of painful and vascularized tumor on color Doppler US, an acral calcified ALM should be considered as the differential diagnosis if the mass shows the calcification on high-resolution US in acral regions.

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“…The author has reported a subcutaneous NF representing compressed fascia using both highresolution ultrasonography (US) and magnetic resonance imaging (MRI) appearances [4] and a rare case of intradermal type showing the primarily in the dermis accompanied by the dilatation and proliferation of the vessels using high-resolution color Doppler ultrasound [5], it is known that high-resolution US can clearly represent the location of the dermis and subcutaneous, association of the fascia, and the presence of dilation and proliferation of the vessels. The author usually performs US studies for dermatologic fields with a high-resolution, broad-band (5MHz-18MHz) linear transducer and described several studies [4,5,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: High-resolution Ultrasonography Appearances In Nodular Fasciitismentioning

confidence: 99%

Nodular fasciitis: USP6-associated neoplasia through multiple pathways

Fujioka¹

2021

JCRCT

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Even though nodular fasciitis (NF) is benign and self-limited nature, the presentations of clinical, ultrasonographic, and pathological features have been described as mimicking sarcoma. Erickson-Johnson et al. suggested that ubiquitin-specific protease 6 (USP6) transcriptional upregulation may be the driving force behind the high proliferative activity and growth of NF. When the lesion showed the proliferative findings of the margin on both ultrasonography (US) and pathology, accompanied by clinically rapid growth, self-limited and/or regress course, NF could be strongly suggested as previously described. In this article, the author reviews the current knowledge of NF as USP6-associated neoplasia and also describes the therapeutic strategy in NF. In addition to the presentations of clinical, ulrtrasonographic, and pathological appearances of NF, the evaluation of percentage of USP6 break-apart FISH signals reflecting lifetime and mitotic counts in NF may be a potential procedure for accurate diagnosis in particularly young NF. It is putative that the inhibition of USP6-related genes might be the potential therapeutic strategies for the extremely rare malignant nodular fasciitis.

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Characteristic Appearances of Peripheral Schwannoma on High-Resolution Ultrasonography And MRI: Comparison Between Antoni A-Dominant and Antoni B-Dominant Types

Cited by 3 publications

References 34 publications

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma

Acral Calcified Angioleiomyoma Along with Radiological Features

Nodular fasciitis: USP6-associated neoplasia through multiple pathways

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