Characteristic Distribution of Mast Cells in Dog Liver

Fujita, Tsuneo

doi:10.1679/aohc1950.24.435

Cited by 13 publications

(1 citation statement)

References 8 publications

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“…Many studies are available in the human literature investigating MC populations in various organs and tumors [17], with several researches concerning human prostate tissue [22,23,24,25,41,42,43]. In contrast, as far as the veterinary literature is concerned, only a few studies have been carried out in order to evaluate MC distribution and morphological features in normal organ and tissues [44,45,46,47,48], or to investigate MCD in neoplastic conditions [35,39,49,50,51,52], especially in relation to angiogenesis [35,47,51], and no information is available regarding prostate tissue.…”

Section: Discussionmentioning

confidence: 99%

Tumor–Microenvironment Interaction: Analysis of Mast Cell Populations in Normal Tissue and Proliferative Disorders of the Canine Prostate

Defourny

Romanucci

Grieco

et al. 2019

Veterinary Sciences

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Mast cells (MCs) are involved in angiogenesis, tissue remodeling and immunomodulation in several human and animal tumors, although their exact role is still controversial. Since no information is available in canine prostate carcinoma (PC) and normal prostate tissues, the aims of this study were to evaluate the possible correlations between MC distribution, molecular expression and microvessel density (MVD) in normal prostatic tissue and proliferative disorders of the canine prostate. All samples (6 normal, 15 benign prostate hyperplasia-BPH, 8 PC) were stained with Toluidine Blue and immunohistochemically evaluated for tryptase, c-Kit (CD117) and CD31. Mast cell density (MCD) and MVD were quantified by the hot-spot method. MCD was significantly increased in periglandular/peritumoral areas, when compared with intraglandular/intratumoral areas, in all groups (p = 0.03). C-Kit expression was strongly associated with PC (ρ = 0.75 p = 0.03), whereas positive correlation between tryptase and c-Kit expression (ρ = 0.64 p = 0.01) was observed in periglandular areas of BPH. MVD showed a correlation with MCD in BPH (ρ = 0.54 p = 0.04). Our data support the importance of c-Kit in regulating MC proliferation. The predominant location of MCs in peritumoral areas of canine PC was similar to the human counterpart, in which PC cells are supposed to produce substances attracting MCs to the tumor microenvironment.

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