Characteristic features of cutaneous melanoma in a dermatology referral centre in Tehran, Iran

Kamyab, Kambiz; Kazemi, Sheyda; Azimi, Pourya; Azizpour, Arghavan; Ghandi, Narges; Pirooz, Elham; Noormohammadpour, Pedram; Mirshams-Shahshahani, Mostafa; Daneshpazhooh, Maryam

doi:10.1111/ajd.12616

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…However, Alshedoukhy A et al [8] reported a female predominance and a younger average age in their study. According to data from the literature [9,10], the lower limbs are the most common localization of skin melanoma, which is similar to our findings. In our study, the most frequent localization site of skin melanoma observed in the lower limb was the sole, followed by the head and neck.…”

Section: Discussionsupporting

confidence: 92%

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Tahiri Elousrouti,

Hammas,

Fadlallah

et al. 2023

Cureus

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Background Cutaneous cancer is the most common malignancy type, among which melanomas are considered the most aggressive and lethal. In Morocco, skin melanoma is the 25th most common cancer. To our knowledge, this is the first and largest Moroccan study specifically describing cutaneous melanoma. Materials and methods We obtained data for 100 patients diagnosed with cutaneous melanoma in the Department of Pathology of Hassan II University Hospital, Morocco. Clinical, histopathological, molecular, and follow-up data were recorded from pathology request forms and the patient’s medical records. Results The mean age of our patients was 65 years old. Histologically, the most prevalent were the nodular (48%) and acro-lentiginous (38%) melanoma subtypes. A total of 66% of the patients had a Breslow thickness of >4 mm. The presence of ulceration was noted in 46% of cases. The average mitoses was 9/1 mm². A total of 44% of patients had metastatic melanoma at the time of diagnosis. The BRAF V600E mutation was found in six cases, and the C-KIT mutation in five cases. The five-year overall survival and metastasis-free survival were 85% and 15%, respectively. There was a significant correlation between Breslow thickness and Clark’s level ( p <0.001), histologic subtype ( p =0.012), and presence of metastasis ( p =0.002). There was a significant difference between the head and neck melanomas and those of the feet, particularly in the histological subtype and the presence of ulceration. BRAF V600E mutation was found in six cases of metastatic melanomas of the head and neck, of which three cases were positive for this mutation, as compared with the 23 cases of acral melanomas, which tested negative for the same mutation. Conclusion The results of our study showed that cutaneous melanomas were characterized by advanced age at diagnosis and late-stage diagnosis with a high Breslow index. The lower limbs were the most affected sites, especially in the plantar region. The acral lentiginous subtype was the most common. The presence of BRAF V600E mutation was associated with a better prognosis.

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Section: Discussionsupporting

confidence: 92%

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Tahiri Elousrouti,

Hammas,

Fadlallah

et al. 2023

Cureus

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“…As previous studies conducted in Iran's different cities showed, the most common histopathological subtype in our study was ALM. The prevalence of the ALM subtype in the Kamyab et al's study [ 9 ] in Tehran was 30%, and in the Handjani et al's study [ 10 ] in southern Iran was 44.8%. These results are consistent with other research studies conducted in the Asian and dark-skinned populations [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 96%

Histopathological Characteristics of Cutaneous Melanoma in Isfahan, Iran, from 2013 to 2018

Malakoutikhah

Mohaghegh

Karimi

et al. 2022

Journal of Skin Cancer

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Objectives. To investigate the histopathological characteristics of cutaneous melanoma in Isfahan from 2013 to 2018, according to histopathological subtype, lesions location, Clark level, and Breslow thickness. Methods. A descriptive, retrospective study in reports of Alzahra Hospital and Dr. Rajabi Pathology Laboratory in Isfahan. Results. In total, 45 patients were included in this study. The most prevalent histopathological subtype was acral lentiginous melanoma (48.89%), followed by lentigo maligna melanoma (17.78%), nodular melanoma (11.11%), and superficial spreading melanoma (8.89%). Most malignant lesions were on the foot and toes (31.1%) and face (24.4%). Tumor invasion level was mainly at Clark level IV (42.2%). Furthermore, the mean depth of tumor penetration (Breslow thickness) was 3.87 ± 3.35. Conclusions. Our study revealed the characteristics of melanoma in the Iranian population. Our results showed a similar trend with previous studies in the Asian population. Further investigations are needed to elucidate the role of ethnic and environmental risk factors for developing melanoma in different populations.

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Skin Cancer: Genetics, Immunology, Treatments, and Psychological Care

Tavakolpour

Daneshpazhooh

Mahmoudi

2017

Cancer Genetics and Psychotherapy

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Characteristic features of cutaneous melanoma in a dermatology referral centre in Tehran, Iran

Cited by 4 publications

References 25 publications

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Histopathologic and Molecular Features of Cutaneous Melanoma in a Moroccan Population

Histopathological Characteristics of Cutaneous Melanoma in Isfahan, Iran, from 2013 to 2018

Skin Cancer: Genetics, Immunology, Treatments, and Psychological Care

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