Characteristic linear lesions and longitudinally extensive spinal cord lesions in Chinese patients with neuromyelitis optica

Liu, Zhengqi; Qiu, Wei; Zou, Yan; Lv, Kefeng; Long, Youming; You, Wenxia; Zheng, Xueping; Hu, Xueqiang

doi:10.1016/j.jns.2010.02.026

Cited by 32 publications

(23 citation statements)

References 20 publications

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“…Serum NMOIgG antibodies were tested using aquaporin 4-transfected cells from a commercial sampling kit (EUROIMMUN AG, Lübeck, Germany) according to the manufacturer's instructions. The sensitivity and specificity of NMO-IgG by this method for NMO patients in our cohort was 84.0 and 85.0%, respectively [8].…”

Section: Laboratory Testsmentioning

confidence: 58%

“…The MS Center of the Third Affiliated Hospital of Sun YatSen University is one of the largest referral centers for MS and other demyelinating diseases in Southern China [8]. Potential ATM cases were identified by querying the patient database from January 1, 1995 to October 31, 2009 for a final diagnosis of myelopathy, myelitis, MS, or NMO.…”

Section: Patients and Classificationmentioning

confidence: 99%

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Acute transverse myelitis in demyelinating diseases among the Chinese

Qiu

Liu

et al. 2011

J Neurol

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The aim of the study was to characterize the demographic, clinical, and prognostic features of Chinese patients with acute transverse myelitis (ATM). The clinical data from ATM patients in a demyelinating disease database were analyzed retrospectively. Sixty-seven ATM patients with a follow-up duration longer than 2 years were identified. The frequency of neuromyelitis optica-related ATM (NMO-ATM) was high in our cohort (40.3%). Recurrent ATM (R-ATM), with a female predominance, was common in total idiopathic ATM (69.0%, 20/29). In R-ATM with longitudinally extensive spinal cord lesions (LESCLs), the high seropositivity of NMO-IgG, spinal cord lesions mostly involved the central gray matter and severer long-term disability were similar to NMO-ATM. In RTM without LESCLs, low seropositivity of NMO-IgG, preferentially involvement of the peripheral white matter and relative better neurological recovery were consistent with multiple sclerosis-related ATM (MS-ATM). The transition rates to MS in patients with acute partial transverse myelitis (APTM) and acute complete transverse myelitis (ACTM) were not significant (16.7 vs. 6.3%, P = 0.753), while LESCLs (OR = 11.4, P = 0.028) were significantly correlated with transition to NMO. The presence of LESCLs was the only variable showing a higher risk for reaching Rankin 3 (hazard ratio: 2.5, 95% CI: 1.0-6.1). Chinese patients with ATM had demographic, clinical, and prognostic features different from those in Western populations. Idiopathic R-ATM, common in Chinese, is a heterogeneous entity that shares partial clinical, spinal MRI and prognostic features with MS-ATM and NMO-ATM. The length of spinal cord lesion, rather than APTM/ACTM, may be a prognostic factor associated with clinical outcome and long-term disability in our population.

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Section: Laboratory Testsmentioning

confidence: 58%

Section: Patients and Classificationmentioning

confidence: 99%

Acute transverse myelitis in demyelinating diseases among the Chinese

Qiu

Liu

et al. 2011

J Neurol

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“…Anti-AQP4 antibody status was determined by anti-AQP4 antibody assay on an anti-AQP4-transfected cell line from a commercial Biochip kit (Euroimmun, Germany) [18] . Briefly, serum (1: 10) or CSF (1: 1) was diluted in phosphate-buffered saline (PBS).…”

Section: Anti-aqp4 Antibody Testing In Csf and Serummentioning

confidence: 99%

Aquaporin 4 Antibodies in the Cerebrospinal Fluid Are Helpful in Diagnosing Chinese Patients with Neuromyelitis Optica

Long

Qiu

Liu

et al. 2012

Neuroimmunomodulation

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Objective: It was the aim of this study to compare the diagnostic efficiency of anti-aquaporin 4 (AQP4) antibody detection between serum and cerebrospinal fluid (CSF) samples in Chinese patients with central nervous system demyelinating diseases. Methods: Anti-AQP4 antibodies were detected by a cell-based assay. We calculated the sensitivity, specificity and coherence in 118 patients with neuromyelitis optica (NMO, n = 39), multiple sclerosis (n = 34), longitudinally extensive transverse myelitis (LETM, n = 22), optic neuritis (ON, n = 6), opticospinal multiple sclerosis (n = 8) and acute partial transverse myelitis (n = 9). Results: Forty-four serum samples (33.8%) were positive for anti-AQP4 antibodies. Anti-AQP4 antibody seropositivity was 76.9, 59.1 and 16.7% in patients with NMO, LETM and ON, respectively. Sixty-five CSF samples (50%) were positive for anti-AQP4 antibodies. Anti-AQP4 antibody positivity was 87.1, 81.8, 83.3, 62.5 and 11.8% in patients with NMO, LETM, ON, opticospinal multiple sclerosis and multiple sclerosis, respectively. The ĸ value of the coherence test was 0.585 (p < 0.0001) between the two types of samples. The antibody positivity rate was significantly different between the two body fluids (p = 0.0008, McNemar test). The sensitivity and specificity were 74.3 and 100% in serum, 85.7 and 88.2% in CSF, and 94.3 and 88.2% for serum and CSF combined, respectively. Conclusion: The sensitivity of anti-AQP4 antibodies in the CSF was higher than that in the serum, and their combined use is helpful in diagnosing Chinese patients with NMO.

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“…6 Linear medullary lesions reported in 48% of Chinese patients discriminate between NMOSD and MS and our patient had such involvement of the medulla. 9 Atypical presentations such as seen in our patient could delay a diagnosis of NMOSD. This may cause increased morbidity as each relapse is likely to result in disability.…”

Section: Oy-stersmentioning

confidence: 65%