Characteristic Regional Cerebral Blood Flow Patterns in Anorexia Nervosa Patients With Binge/Purge Behavior

Naruo, Tetsuro; Nakabeppu, Yoshiaki; Sagiyama, Ken-ichiro; Munemoto, Takao; Homan, Naoko; Deguchi, Daisuke; Nakajo, Masayuki; Nozoe, Shigeo

doi:10.1176/appi.ajp.157.9.1520

Cited by 61 publications

(29 citation statements)

References 8 publications

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“…As described above, previous brain imaging studies have shown pictures of food to emaciated and malnourished AN individuals. These studies found altered activity not only in the insula and OFC, but in broad regions including mesial temporal, parietal, and the anterior cingulate cortex when ill AN subjects were compared to controls (122,(125)(126)(127)129,197).…”

Section: Feeding Behaviormentioning

confidence: 97%

“…When emaciated and malnourished AN individuals are shown pictures of food, they display abnormal activity in the insula and orbitofrontal cortex (OFC) as well as in mesial temporal, parietal, and the anterior cingulate cortex (122)(123)(124)(125)(126)(127). Studies using SPECT, PET-O15, or fMRI, found that when subjects ill with AN ate food, or were exposed to food, they had activated temporal regions, and often increased anxiety (122,(124)(125)(126). Those results could be consistent with anxiety provocation and related amygdala activation, and the notion that the emotional value of an experience is stored in the amygdale (128).…”

Section: Appetitive Regulationmentioning

confidence: 99%

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Neurobiology of anorexia and bulimia nervosa

Kaye

2008

Physiology & Behavior

527

369

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Section: Feeding Behaviormentioning

confidence: 97%

Section: Appetitive Regulationmentioning

confidence: 99%

Neurobiology of anorexia and bulimia nervosa

Kaye

2008

Physiology & Behavior

527

369

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“…Furthermore, brain imaging has been performed in conjunction with paradigms and tasks that are meant to elicit areas of brain activation that might be specific to AN pathophysiology [12] . Most paradigms are based on 2 integral parts of AN pathophysiology: weight phobia [13][14][15][16] and body image distortion [17][18][19][20] . Among these studies, imaging modalities and tasks are not consistent, and some patient groups are small.…”

Section: Influence Of Satiety and Subjective Valence Rating On Cerebrmentioning

confidence: 99%

Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women

Gizewski¹,

Rosenberger

Greiff³

et al. 2010

Neuropsychobiology

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Background: There is evidence that patients with anorexia nervosa (AN) demonstrate specific cerebral activation patterns in response to visual food stimulation. We postulated that cerebral activation patterns could represent different perceptions of high-calorie images during hunger and satiety and could be determined by patients’ subjective ratings. Methods: After 6 h of starvation and also in a state of satiety, 12 female patients with AN and 12 normal-weight women were assessed by use of fMRI with high-calorie food images. All patients suffered from a restrictive type of AN. Heart rates, subjective ratings of satiety and valences of the visual stimuli were assessed. Results: Food stimuli presented during a state of hunger were associated with significant activation of the anterior cingulate cortex and insula in the control group and of the prefrontal and central cortices and insula in the AN group. During the hunger state activation in AN of the dorsal posterior cingulate cortex was revealed compared to the controls. In the state of satiety, activation of the left insula was observed in the AN group. Use of the food valence judgment as a covariate confirmed the insula activation and revealed additional activation of the orbitofrontal, cingulate and medial temporal cortices. Conclusion: Our results indicate differences in cerebral activation patterns due to different perceptions of high-calorie food images, modulated by feelings of hunger or satiety, among AN patients with modulation by subjective ratings of food valence.

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“…Previous brain imaging studies have shown pictures of food to emaciated and malnourished AN individuals. These studies found altered activity not only in the insula and OFC, but in broad regions including mesial temporal, parietal, and the anterior cingulate cortex when ill AN subjects were compared to controls (Nozoe et al, 1993;Ellison et al, 1998;Naruo et al, 2000;Gordon et al, 2001;Uher et al, 2004). In addition, one study used pictures of food and functional magnetic resonance imaging (fMRI) to study individuals who were recovered from AN (Uher et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa

Wagner

Aizenstein

Mazurkewicz

et al. 2007

Neuropsychopharmacol

239

203

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Anorexia nervosa (AN) is an illness characterized by aversion to ingestion of normally palatable foods. We examined whether there is a primary disturbance of taste processing and experience of pleasure using a sucrose/water task in conjunction with functional magnetic resonance imaging (fMRI). To avoid confounding effects of illness, 16 women recovered from restricting-type AN were compared to 16 control women (CW). We used a region of interest-based fMRI approach to test the idea that individuals with AN have differential neural activation in primary and secondary taste cortical regions after sucrose and water administration. Compared to CW, individuals recovered from AN showed a significantly lower neural activation of the insula, including the primary cortical taste region, and ventral and dorsal striatum to both sucrose and water. In addition, insular neural activity correlated with pleasantness ratings for sucrose in CW, but not in AN subjects. Altered taste processing may occur in AN, based on differences in activity in insular-striatal circuits. These data provide the first evidence that individuals with AN process taste stimuli differently than controls, based on differences in neural activation patterns.

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Characteristic Regional Cerebral Blood Flow Patterns in Anorexia Nervosa Patients With Binge/Purge Behavior

Abstract: Specific activation in cortical regions suggests an association between habitual binge/purge behavior and the food recognition process linked to anxiety in patients with anorexia nervosa.

Cited by 61 publications

References 8 publications

Neurobiology of anorexia and bulimia nervosa

Neurobiology of anorexia and bulimia nervosa

Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women

Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa

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