Characteristic spectral studies and in vitro Antimicrobial and in vivo multi‐infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions: Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium

“…However, the small shift of this band either may be due to the shifting of δ(N-H) def which is caused by the coordination of NH 2 to tin or their participation in the intermolecular hydrogen bonding, as reported previously for R 3 Sn(HL) (H 2 L = dipeptide) derivatives [12,19]. The ν as (Sn-C) and ν s (Sn-C) bands in all of the di-and trialkyltin(IV) tyrosylalaninates are observed in the range 634 ± 43 cm −1 , whereas in the di-and triphenyltin(IV) tyrosylalaninates, the corresponding ν as (Sn-C) and ν s (Sn-C) are observed at 230 ± 17 cm −1 and 227 ± 1 cm −1 , respectively, suggesting the existence of a bent C-Sn-C moiety [1,7].…”

“…For Me 2 Sn(IV)-dipeptide systems, the carboxylate group acts as an anchoring group for the metal-promoted deprotonation of the amide nitrogen (assistied by chelate formation). It has been found that in these dipeptide ligands, [−C(O)O − , N − , NH 2 ] coordinated complexes are dominant in the neutral pH (6)(7)(8) range with a trigonal-bipyramidal structure. Therefore, it can be concluded that R n Sn (4−n)+ (n = 2 and 3) species may interact strongly with the O/N donor groups of the protein and can effectively disturb DNA duplication process, and the interaction of organotin(IV) moiety with tyrosylalanine may serve as model for metalprotein interactions.…”

“…In order to get a better insight in how the organotin species behave inside the biological systems, it is necessary to study their coordination behavior with biomolecules that can occur in the biological medium. Therefore, considerable efforts have been made to understand the binding mode of organotin compounds with biologically relevant ligands such as amino acids [1,2,[7][8][9][10][11][12][13] and dipeptides [1,2,[12][13][14][15][16][17][18][19][20][21][22][23][24], which constitute a very important class of biomolecules. Further, diorganotin(IV) derivatives of dipeptides [12,14,18] have been found to exhibit potent anti-inflammatory activity; thus such compounds may hold the potential to be placed in the class of nonsteroidal anti-inflammatory drugs (NSAIDs).…”

“…Model studies using small peptides as low-molecular-weight protein mimics may furnish essential 2 ISRN Spectroscopy details on the metal ion-protein interactions. Several investigations are directed at exploring the coordination chemical behavior of di-and triorganotin(IV) cations towards amino acids [1,2,[7][8][9][10][11][12][13], dipeptides [1,2,[12][13][14][15][16][17][18][19][20][21][22][23][24], or tripeptides [12,25,26] in the solid state. However, a few works focused on the solution equilibrium studies for such systems [27][28][29][30] which could provide essential information on the biospeciation of organotin moiety and thus on its bioavailability.…”

In Vitro and in Silico Antimicrobial Study of Stannane of Pyridoxal 5-Phosphate

“…Stannanes have gained an edge over other organometallics owing to their bioavailability in ecosystem and entrance into the food chain, the fact they are less dangerous to the environment and their pharmaceutical applications [3]. So by keeping in mind the various applications of stannane/ organotin (IV) complexes and further continuation of our work [4,5], we here report the synthesis, characterization, in vitro and insilico antimicrobial study of stannane of pyridoxal 5-phosphateto develop a novel broad-spectrum antibacterial agent.…”