Characteristics and 1-Year Prognosis of Medically Treated Patients With Chronic Heart Failure in Japan-Chronic Heart Failure Analysis Registry in Tohoku District (CHART)-

Koseki, Yoshito; Watanabe, Jobu; Shinozaki, Takahiro; Sakuma, Masashi; Komaru, Tatsuya; Fukuchi, Mitsumasa; Miura, Makoto; Karibe, Akihiko; Konno, Yuji; Numaguchi, Hirotaka; Ninomiya, Mototsugu; Kagaya, Yutaka; Shirato, Kunio

doi:10.1253/circj.67.431

Cited by 35 publications

(31 citation statements)

References 23 publications

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“…8) Some investigations in Japanese subjects have shown that plasma BNP is useful as an independent factor for estimation of the outcome and prediction of sudden death. 9,10) On the other hand, plasma BNP has been reported to increase with increases in the grade of severity of heart disease according to the NYHA classification in a way similar to the plasma levels of ANP, cGMP, and norepinephrine.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between the Plasma Levels of Brain Natriuretic Peptide and Left Ventricular Ejection Fraction in Asymptomatic Patients With Previous Myocardial Infarction

et al. 2005

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SUMMARYWhile the usefulness of measuring the plasma levels of brain natriuretic peptide (BNP) in cases with worsening heart failure and severe heart failure has already been established, the benefits of evaluation of this parameter in asymptomatic stable patients with left ventricular dysfunction is still under debate. Left ventricular function was evaluated in 141 ambulatory outpatients with a previous history of myocardial infarction not associated with symptoms of heart failure for at least one year. The plasma BNP level was also determined in these patients for comparative study. No correlation between the plasma level of BNP and EF was noted in the normal-EF group, while a negative correlation between the two parameters was observed in the low-EF group (Y = 0.439 -0.000266X) (R2 = 0.244, P < 0.0001). The sensitivity was 91.5%, specificity 56.3%, positive predictive accuracy value 61.9%, and negative predictive accuracy value 83.8% for a plasma BNP cut-off level of 89.0 pg/mL.The results suggested that it might be meaningful to measure the plasma BNP level, especially in asymptomatic patients with a previous history of myocardial infarction having a low-EF. (Int Heart J 2005; 46: 1007-1014 Key words: Brain natriuretic peptide, Ejection fraction, Myocardial infarction, Ambulatory outpatients BRAIN natriuretic peptide (BNP) is known to be secreted mainly from the myocardium in acute heart failure and chronic heart failure, to show more marked variation in levels than is known for other neurohumoral factors, 1) and to be correlated with indices of left ventricular functions, including pulmonary artery wedge pressure and left ventricular ejection fraction (EF).

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Section: Discussionmentioning

confidence: 99%

Relationship Between the Plasma Levels of Brain Natriuretic Peptide and Left Ventricular Ejection Fraction in Asymptomatic Patients With Previous Myocardial Infarction

et al. 2005

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“…The main protocol characteristics and results of some studies (87)(88)(89)(90)(91) that evaluated the prognostic value of CNH assays in patients with HF are reported in Table 6. In all of these studies, BNP and NT-proBNP (but not ANP and NT-proANP) were always found to be independent risk markers for morbidity and/or mortality (87)(88)(89).…”

Section: Prognosis In Hfmentioning

confidence: 99%

Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review

2004

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Background:The pathophysiologic and clinical relevance of cardiac natriuretic hormone (CNH) assays has been investigated in numerous experimental and clinical studies. Authors have sought to evaluate the diagnostic accuracy and prognostic relevance of the measurement of CNHs according to evidence-based laboratory medicine principles. Methods: In June 2003, we ran a computerized literature search on National Library of Medicine using keywords "ANP" and "BNP" and found more than 12 300 and 1200 articles, respectively. A more refined search with keywords "ANP or BNP assay" extracted ϳ7000 and 800 articles, respectively. Only studies specifically designed to evaluate the diagnostic accuracy and prognostic relevance of CNH measurements were selected from this huge mass of articles to be discussed in this review. Content: Several studies suggested that CNH assays may be clinically useful for the screening and classification of patients with heart failure, as a prognostic marker in cardiovascular disease, in the follow-up of patients with heart failure, and because they may reduce the need for further cardiac investigation. However, it is difficult to compare even the best-designed studies because not only did the authors evaluate different populations, they also used different gold standards. Conclusions: CNH assays and conventional diagnostic work-ups provide complementary information for evaluation of the presence and severity of cardiac dysfunction and clinical disease. Several aspects of CNH assays are still to be elucidated, and further work is needed to

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“…BNP is a strong predictor of morbidity and mortality in heart failure (51). It has been shown that BNP as well as troponin I and CK-MB levels were elevated in stress CMP as in heart failure or acute myocardial infarction, and increased BNP levels were related to clinical severity, hemodynamic stress, and myocardial contractility (37,38).…”

Section: G6mentioning

confidence: 99%

The relationship of thyroid hormone status with myocardial function in stress cardiomyopathy

Lee

Kang

Ryu

et al. 2009

European Journal of Endocrinology

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Objective: This study aimed to investigate thyroid hormone (TH) status and its relationship with myocardial function as well as clinical and biochemical parameters in stress cardiomyopathy (CMP). Methods: Forty-five patients with stress CMP (the patient group), 31 patients without stress CMP (the control II group), and 58 healthy subjects (the control I group) were included. Sick euthyroid syndrome (SES) was defined as low total triiodothyronine (T 3 ) with normal TSH levels. Results: In the patient group at admission, prevalence of SES was 62.2%. Compared with the control I group, the patient group had a decrease in left ventricular ejection fraction (LVEF) and systolic blood pressure (BP) and an increase in troponin-I, CK-MB, and B-type natriuretic peptide (BNP) levels. Total T 3 levels were reduced, and anti-thyroid peroxidase antibody (anti-TPO Ab) positivity, C-reactive protein (CRP) and cortisol levels were elevated. Total T 3 levels were associated with acute physiology and chronic health evaluation II (APACHE II) score, LVEF, systolic BP, and cortisol levels in multivariate analysis. In the control II group, total T 3 levels were not associated with any variables. In the SES (nZ28) and myocardial dysfunction (MDys, nZ27) subgroups, increased APACHE II score and BNP levels as well as decreased LVEF and systolic BP were significant. Total T 3 levels were reduced, and CRP, cortisol and catecholamines levels were elevated. In the MDys subgroup, anti-TPO Ab positivity and titer were increased. Conclusion: These results suggest that total T 3 levels may be associated with myocardial contractility, clinical severity, and cortisol levels. Thyroid autoimmunity may influence myocardial contractility in stress CMP.

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Characteristics and 1-Year Prognosis of Medically Treated Patients With Chronic Heart Failure in Japan-Chronic Heart Failure Analysis Registry in Tohoku District (CHART)-

Cited by 35 publications

References 23 publications

Relationship Between the Plasma Levels of Brain Natriuretic Peptide and Left Ventricular Ejection Fraction in Asymptomatic Patients With Previous Myocardial Infarction

Relationship Between the Plasma Levels of Brain Natriuretic Peptide and Left Ventricular Ejection Fraction in Asymptomatic Patients With Previous Myocardial Infarction

Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review

The relationship of thyroid hormone status with myocardial function in stress cardiomyopathy

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