Characteristics and anticancer properties of Sunitinib malate-loaded poly-lactic-co-glycolic acid nanoparticles against human colon cancer HT-29 cells lines

Abstract

Purpose: To develop poly-lactic-co-glycolic acid (PLGA)-based nanoparticles (NPs) for the delivery of sunitinib malate (STM) to colon cancer cells. Methods: Three different formulations (F1-F3) were developed by nano-precipitation technique using various concentrations of PLGA. The NPs were evaluated for particle size, polydispersity index, zeta potential, drug entrapment, and drug loading, using differential scanning calorimetry (DSC), Fouriertransform infrared spectroscopy (FTIR), x-ray diffraction (XRD), and scanning electron microscopy (SEM). Furthermore, in vitro drug release and anticancer studies were carried out on the formulations. Results: Among the three NPs, optimized NP (F3) of STM was chosen for in vitro anti-cancer study against H-29 human colon cancer cells lines based on its particle size (132.9 nm), PDI (0.115), zeta potential (-38.12 mV), entrapment efficiency (52.42 %), drug loading (5.24 %), and drug release (91.26 % in 48 h). A significant anti-cancer activity of the optimized NPs was observed, relative to free STM. Conclusion: These findings suggest that STM-loaded NPs possess significant anti-cancer activity against human colon cancer HT-29 cells lines.

Boosting the Anticancer Activity of Sunitinib Malate in Breast Cancer through Lipid Polymer Hybrid Nanoparticles Approach

“…Peaks at the fingerprint region were interpreted, and additional or absent peaks were then studied for possible functional group interactions between drug and excipients. Spectrums were then collaged and presented for compatibility study [33].…”

“…Sample (pure SM and SLPN4) were characterized by XRD to identify the nature of solid-state. X-ray diffractometer (Ultima IV, Rigaku Inc., Tokyo, Japan) was used with the following set parameters: Cu-kα radiation at 40 kV/40 mA, scan rate of 0.500 • /min in the 0-60 (2θ) range, at a fixed monocromator (U4), attached with scintillation detector [33].…”

Development of NIPAAm-PEG acrylate polymeric nanoparticles for co-delivery of paclitaxel with ellagic acid for the treatment of breast cancer

“…The size and morphology are the two most important parameters that decide if these particles can be used as a carrier for drugs or not [22]. Blank nanoparticles showed the size of about 123 ± 2 nm.…”

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“…When the gelation process is complete, the alginate cannot return to the sol phase. Therefore, alginate is classified to be an irreversible impression material and distinguished from reversible impression materials [6][7][8][9][10][11][12]. Alginates are found in both marine brown algae (Phaeophyceae) and bacteria as capsular polysaccharides, although all commercial alginates are currently derived from algal sources alone.…”