Characteristics and Antioxidant Activity of Lignans in Schisandra chinensis and Schisandra sphenanthera from Different Locations

Abstract

Twenty Schisandra samples were collected from different locations. Contents of 7 lignans in the samples were determined and analyzed by HPLC method coupled with hierarchical clustering analysis (HCA) and principal component analysis (PCA), and the antioxidant capacity of Schisandra from the different locations was evaluated by reducing power, ferric thiocyanate (FTC) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) assay. The results showed that there was a significant difference in the content of lignans between Schisandra chinensis and Schisandra sphenanthera. The Schisandra sphenanthera samples in the southwest of China were significantly different from those from the other locations. The antioxidant capacity of Schisandra chinensis was significantly superior to that of Schisandra sphenanthera, and the main antioxidant components were schisandrol A, schisandrol B and schisandrin B based on the result of discrimination analyses. The differences in the chemical composition and antioxidant activity of lignans in Schisandra chinensis and Schisandra sphenanthera from the different locations were investigated in this study, which may provide an experimental basis for the quality control of Schisandra.

Anti‐Aging Effects of Schisandrae chinensis Fructus Extract: Improvement of Insulin Sensitivity and Muscle Function in Aged Mice

“…Presently, we have not been able to identify the active component responsible for the observed beneficial effects on the muscles of aged mice. SF contains many bioactive compounds including lignans, triterpenoids, flavonoids, polyphenol, and polysaccharides [43], and lignans are known to be a major component of SF [43, 44]. Accordingly, we speculated that one or some lignans might be the active compound responsible for this effect, and further studies are required to identify the active ingredients.…”

Combined In Vitro Studies and in Silico Target Fishing for the Evaluation of the Biological Activities of Diphylleia cymosa and Podophyllum hexandrum

“…Regarding the antioxidant capacity of these compounds, studies by Wang et al [88] evaluated the ability of the extracts of S. chinensis and S. sphenanthera to scavenge the DPPH radical. The authors suggested that variations in lignan content between the extracts lead to different antioxidant activities.…”

Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives

“…The chemical composition and resulting biological activity of plant extracts depends on humidity, light, soil type, latitude, season, maturity, harvest time, geographical location, temperature, and other factors [18]. Additionally, the content of individual lignans in SCE fruits depends on the location of the crop, the degree of fruit maturity, and harvest season [19,20,21]. Zhang et al, (2009) studied ten fruit samples from different provinces of China [19].…”

“…This compound constituted 31%–33% of the Schisandra lignans in fruits originating from Korea, and 36%–46% of those from China. In eight out of ten fruit samples, tested by Wang et al, the relationship in the concentration of SCE lignans was schisandrin > gomisin A > schisandrin B [21].…”