Characteristics and applications of cyclodextrin complexes

Żandarek, Joanna; Gumułka, Paweł; Starek, Małgorzata; Dąbrowska, Monika

doi:10.32383/farmpol/152762

Cited by 2 publications

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“…Based on the information presented above, searching for new administration forms of this drug and modifying its release rate is necessary. Cyclodextrins (CDs) are cyclic oligosaccharides linked by α-1,4-glycosidic bonds [12]. Due to the hydrophilic outer surface, they are well soluble in water, while the inner space is hydrophobic and may contain another hydrophobic substance, forming an inclusion complex.…”

Section: Introductionmentioning

confidence: 99%

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Controlled Delivery of Celecoxib—β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Jarosz,

Latosiński,

Gumułka

et al. 2023

Pharmaceutics

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Considering the potential of nanostructured titanium dioxide layers as drug delivery systems, it is advisable to indicate the possibility of creating a functional drug delivery system based on anodic TiO2 for celecoxib as an alternative anti-inflammatory drug and its inclusion complex with β-cyclodextrin. First, the optimal composition of celecoxib—β-cyclodextrin complexes was synthesized and determined. The effectiveness of the complexation was quantified using isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR) nuclear magnetic resonance (1H NMR), and scanning electron microscopy (SEM). Then, nanostructured titanium dioxide layers (TiO2) were synthesized using the electrochemical oxidation technique. The TiO2 layers with pore diameters of 60 nm and layer thickness of 1.60 µm were used as drug delivery systems. The samples were modified with pure celecoxib and the β-cyclodextrin-celecoxib complex. The release profiles shown effective drug release from such layers during 24 h. After the initial burst release, the drug was continuously released from the pores. The presented results confirm that the use of nanostructured TiO2 as a drug delivery system can be effectively used in more complicated systems composed of β-cyclodextrin—celecoxib complexes, making such drugs available for pain treatment, e.g., for orthopedic surgeries.

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Section: Introductionmentioning

confidence: 99%

“…Cyclodextrins (CDs) are cyclic oligosaccharides linked by α-1,4-glycosidic bonds [ 12 ]. Due to the hydrophilic outer surface, they are well soluble in water, while the inner space is hydrophobic and may contain another hydrophobic substance, forming an inclusion complex.…”

Section: Introductionmentioning

confidence: 99%

Controlled Delivery of Celecoxib—β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Jarosz,

Latosiński,

Gumułka

et al. 2023

Pharmaceutics

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Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines

et al. 2022

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Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native β-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether β-CD), hydroxypropyl β-cyclodextrin, and hydroxyethyl β-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl β-cyclodextrin, and curcumin: hydroxypropyl β-cyclodextrin were 7.33, 7.28, and 19.05 µg/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl β-cyclodextrin complex on the direct cell lines of MCF-7.

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Characteristics and applications of cyclodextrin complexes

Cited by 2 publications

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Controlled Delivery of Celecoxib—β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Controlled Delivery of Celecoxib—β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines

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