Characteristics and clinical correlates of restless legs syndrome in schizophrenia

Na, Kyoung-Sae; Lee, Heon Jeong; Jung, Sung Won; Cho, Sung Nam; Han, Changsu; Kim, Yong Ku; Kim, Seung Hyun; Lee, Min Soo; Joe, Sook Haeng; Jung, In Kwa

doi:10.1016/j.pnpbp.2007.03.011

Cited by 65 publications

(50 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The exclusion criteria were as follows: (1) too psychotic, agitated or mutistic to be interviewed; (2) presence of other axis I diagnoses, mental retardation, a neurological disorder or head injury, or a history of alcohol or other substance abuse, and (3) serious medical diseases or other conditions that could be confused with RLS, such as anemia, renal failure, radiculopathy and peripheral neuropathy. The clinical characteristics and correlates of neuroleptics-induced RLS have been described previously [7] . The study protocol was approved by the ethics committee of the Korea University Medical Center, and all of the participants provided written informed consent.…”

Section: Subjectsmentioning

confidence: 99%

“…There may also be a genetic contribution to antipsychotics-induced RLS, as is the case in idiopathic RLS. Our previous investigation of the characteristics of antipsychotics-induced RLS [7] revealed that the doses of antipsychotics and the cumulative exposure to neuroleptics did not differ between patients with RLS and those without RLS symptoms. This suggests that even though antipsychotics could precipitate RLS symptoms, the susceptibility to RLS differs between individuals.…”

mentioning

confidence: 95%

“…Several cases of antipsychotics-induced RLS have been reported [3][4][5][6] , and we determined that the prevalence of RLS was more than twofold higher in schizophrenics (21.4%) than in controls [7] . Moreover, neuroleptics-induced RLS was shown to be related to severe psychiatric symptoms [7] . Antipsychotics-induced RLS was attributed to blocking of dopamine receptors by antipsychotics [8] .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association Study between Antipsychotics- Induced Restless Legs Syndrome and Polymorphisms of Dopamine D1, D2, D3, and D4 Receptor Genes in Schizophrenia

Choi²,

Park

et al. 2008

Neuropsychobiology

Self Cite

View full text Add to dashboard Cite

Objective: The cause of restless legs syndrome (RLS) is not yet clear, but more promising theories involve dopaminergic deficiency and genetic causes. This study investigated whether single-nucleotide polymorphisms in the genes of dopamine receptors DRD1, DRD2, DRD3 and DRD4 are associated with antipsychotics-induced RLS in schizophrenia. Methods: We evaluated 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group and its rating scale for RLS. Genotyping was performed for the DRD1 gene –48A/G, DRD2 gene TaqI A, DRD3 gene Ser9Gly and DRD4 gene –521C/T single-nucleotide polymorphisms. The method of multifactor dimensionality reduction was used to analyze gene-gene interactions. Results: We classified the schizophrenic patients into 96 with and 94 without RLS symptoms. The genotype frequencies of all polymorphisms investigated did not differ significantly between these 2 groups. MDR analysis did not show a significant effect of the 4 dopamine receptor gene variants on susceptibility to antipsychotic-induced RLS symptoms (p > 0.05). Conclusions: These genetics data suggest that the analyzed polymorphisms of the dopamine genes may not be associated with RLS symptoms in schizophrenia. Confirming the results reported here requires a larger-scale study involving patients taking specific antipsychotics.

show abstract

Section: Subjectsmentioning

confidence: 99%

mentioning

confidence: 95%

mentioning

confidence: 99%

See 1 more Smart Citation

Association Study between Antipsychotics- Induced Restless Legs Syndrome and Polymorphisms of Dopamine D1, D2, D3, and D4 Receptor Genes in Schizophrenia

Choi²,

Park

et al. 2008

Neuropsychobiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Foi estimada em 21,4% a prevalência de SPI na esquizofrenia 54 . Quando a SPI surge em paciente com esquizofrenia em uso de neurolépticos, pode-se mudar de classe de neuroléptico e/ou acrescentar clonazepam 55 .…”

Section: Aumentaçãounclassified

A relevância da síndrome das pernas inquietas (doença de willis-ekbom) para a prática clínica diária com pacientes com transtornos psiquiátricos

Tavares

Dutra

Daker

2017

Debates em Psiquiatria

View full text Add to dashboard Cite

ResumoNo passado, a síndrome das pernas inquietas (SPI) foi conceitualizada como uma neurose de sensibilidade e uma ansiedade na tíbia. O objetivo do presente trabalho é demonstrar para os médicos, particularmente para os psiquiatras, que a SPI, hoje, é uma doença neuropsiquiátrica complexa e crônica, comum e tratável, com acometimento sensório-motor, alterações do sistema dopaminérgico e distúrbios da homeostasia do ferro cerebral. A sintomatologia é exclusivamente subjetiva e pode ser crônico-persistente ou intermitente. Há uma urgência para mover as pernas, acompanhada de disestesia nas mesmas, que piora com repouso ou inatividade, sendo aliviada pelo movimento. O diagnóstico é exclusivamente clínico. Algumas medicações precisam ser reduzidas ou descontinuadas porque podem piorar a SPI: alguns antidepressivos (particularmente inibidores seletivos da recaptação da serotonina, inibidores da recaptação da serotonina e noradrenalina e mirtazapina), neurolépticos, antieméticos, anti-histamínicos e outros. É relevante observar que não há piora com o antidepressivo bupropiona. O tratamento não farmacológico inclui higiene do sono e atividades físicas. As drogas utilizadas no tratamento pertencem a quatro grupos: dopaminérgicos (agonistas diretos e precursores de dopamina); α 2 δ-ligantes; benzodiazepínicos; e opioides. A aumentação é a principal complicação no tratamento de longo prazo: início mais cedo dos sintomas ao longo A RELEVÂNCIA DA SÍNDROME DAS PERNAS INQUIETAS (DOENÇA DE WILLIS-EKBOM) PARA A PRÁTICA CLÍNICA DIÁRIA COM PACIENTES COM TRANSTORNOS PSIQUIÁTRICOS RELEVANCE OF THE RESTLESS LEGS SYNDROME (WILLIS-EKBOM DISEASE) FOR DAILY CLINICAL PRACTICE WITH PATIENTS WITH PSYCHIATRIC DISORDERSdo dia; início mais rápido com o repouso; expansão dos sintomas para os membros superiores e o tronco; e encurtamento do efeito dos tratamentos. Supõe-se que a superestimulação dopaminérgica seja a causa da aumentação.Palavras-chave: Síndrome das pernas inquietas, doença de Willis-Ekbom, transtorno do sono, movimentos periódicos dos membros, metabolismo do ferro cerebral, dopamina. AbstractIn the past, the restless legs syndrome (RLS) was conceptualized as a sensitivity neurosis and tibial anxiety. The objective of the present study is to demonstrate, to physicians in general and psychiatrists in particular, that today, RLS is a complex and chronic, common and treatable, neuropsychiatric disorder with sensorimotor involvement, alterations of the dopaminergic system, and brain iron homeostasis disorders. Symptoms are exclusively subjective and can be chronic-persistent or intermittent. There is an urge to move the legs, accompanied by limb dysesthesias, which worsens with rest or inactivity and improves with movement. Diagnosis is exclusively clinical. Some medications have to be reduced or discontinued because they may worsen RLS, e.g., some antidepressants (particularly selective serotonin reuptake inhibitors, serotonin and noradrenalin reuptake inhibitors, and mirtazapine), neuroleptics, antiemetics, antihistamines, http:/...

show abstract

“…A diagnosis of RLS and PLMS is also typically based on a PSG. There are very few studies of movement-related sleep disorders in SZ, and estimates of RLS and PLMS range between 13% to 21% [29]. The exact neurobiological mechanisms are not understood, although one hypothesis proposes that dopamine deficiency is a likely cause [30].…”

Section: Movement-related Sleep Disordersmentioning

confidence: 99%

Sleep dysfunctions in schizophrenia: A practical review

Waters¹,

Manoach²

2012

OJPsych

View full text Add to dashboard Cite

Characteristics and clinical correlates of restless legs syndrome in schizophrenia

Cited by 65 publications

References 27 publications

Association Study between Antipsychotics- Induced Restless Legs Syndrome and Polymorphisms of Dopamine D1, D2, D3, and D4 Receptor Genes in Schizophrenia

Association Study between Antipsychotics- Induced Restless Legs Syndrome and Polymorphisms of Dopamine D1, D2, D3, and D4 Receptor Genes in Schizophrenia

A relevância da síndrome das pernas inquietas (doença de willis-ekbom) para a prática clínica diária com pacientes com transtornos psiquiátricos

Sleep dysfunctions in schizophrenia: A practical review

Contact Info

Product

Resources

About