Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Chen, Bo‐Yan; Lin, Wei-Ming; Li, Yulin; Bi, Chao; Du, Lin‐Juan; Liu, Yuan; Zhou, Lujun; Liu, Ting; Xu, Shuo; Shi, Chaoji; Zhu, Hong; Wang, Yongli; Sun, Jian‐Yong; Liu, Yan; Zhang, Wu‐Chang; Zhang, Zhiyuan; Zhang, Huili; Zhu, Yaqin; Duan, Sheng-Zhong

doi:10.1128/spectrum.01956-22

Cited by 9 publications

(9 citation statements)

References 68 publications

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“…Fungi derived from dietary sources, such as mushrooms and Ganoderma, were specifically excluded as these fungi are typically transient and lack activity in the gut. Utilizing this database, we observed that Saccharomyces was the most prevalent genus in this cohort, which is supported by previous findings [ 27 – 29 ]. Especially, S. cerevisiae accounted for 41.5% of the fungal composition.…”

Section: Discussionsupporting

confidence: 91%

Altered gut mycobiome in patients with end-stage renal disease and its correlations with serum and fecal metabolomes

Ren,

Chen,

Guo

et al. 2024

J Transl Med

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Background The relationship between the gut mycobiome and end-stage renal disease (ESRD) remains largely unexplored. Methods In this study, we compared the gut fungal populations of 223 ESRD patients and 69 healthy controls (HCs) based on shotgun metagenomic sequencing data, and analyzed their associations with host serum and fecal metabolites. Results Our findings revealed that ESRD patients had a higher diversity in the gut mycobiome compared to HCs. Dysbiosis of the gut mycobiome in ESRD patients was characterized by a decrease of Saccharomyces cerevisiae and an increase in various opportunistic pathogens, such as Aspergillus fumigatus, Cladophialophora immunda, Exophiala spinifera, Hortaea werneckii, Trichophyton rubrum, and others. Through multi-omics analysis, we observed a substantial contribution of the gut mycobiome to host serum and fecal metabolomes. The opportunistic pathogens enriched in ESRD patients were frequently and positively correlated with the levels of creatinine, homocysteine, and phenylacetylglycine in the serum. The populations of Saccharomyces, including the HC-enriched Saccharomyces cerevisiae, were frequently and negatively correlated with the levels of various toxic metabolites in the feces. Conclusions Our results provided a comprehensive understanding of the associations between the gut mycobiome and the development of ESRD, which had important implications for guiding future therapeutic studies in this field.

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Section: Discussionsupporting

confidence: 91%

Altered gut mycobiome in patients with end-stage renal disease and its correlations with serum and fecal metabolomes

Ren,

Chen,

Guo

et al. 2024

J Transl Med

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“…While bacteria are the primary components of the gut microbiome, other symbionts like viruses, fungi, and archaea also play significant roles. Recent studies ( Chen et al, 2023 ; Li et al, 2024 ) have suggested a link between viruses and the incidence of atherosclerotic diseases, indicating that other components of the human symbiotic microbial system, beyond bacteria, may have associations with PAD that warrant further investigation. Our current analysis focuses solely on the correlation between the gut microbiota and PAD, leaving the relationships between other components of the human symbiotic microbial system and PAD to be explored in future research.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota’s causative relationship with peripheral artery disease: a Mendelian randomization study

Tian,

Yao,

Skudder-Hill

et al. 2024

Front. Microbiol.

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IntroductionThe relationship between gut microbiota and peripheral artery disease (PAD) remains understudied. While traditional risk factors like smoking and hyperlipidemia are well-understood, our study aims to determine the potential causative association of gut microbiota with PAD using Mendelian Randomization.MethodsData from the International MiBioGen Consortium and the FinnGen research project were used to study 211 bacterial taxa. Instrumental variables, comprising 2079 SNPs, were selected based on significance levels and linkage disequilibrium. Analyses were conducted utilizing the inverse-variance weighted (IVW) method and other statistical MR techniques to mitigate biases, processed in R (v4.3.1) with the TwosampleMR package.ResultsThree bacterial taxa, namely genus Coprococcus2, RuminococcaceaeUCG004, and RuminococcaceaeUCG010, emerged as protective factors against PAD. In contrast, family. FamilyXI and the genus Lachnoclostridium and LachnospiraceaeUCG001 were identified as risk factors.ConclusionOur findings hint at a causative association between certain gut microbiota and PAD, introducing new avenues for understanding PAD’s etiology and developing effective treatments. The observed associations now warrant further validation in varied populations and detailed exploration at finer taxonomic levels.

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“…Gut microbiome diversity decrease emblematizes that pathogenic strains occupy the ecological niche of the intestinal mucosa, causing harmful bacterial metabolites or gut bacteria to enter the blood through the disrupted intestinal barrier and promote systematic chronic subacute in ammation [22,23]. This ongoing systemic in ammation can drive the progression of metabolic disease [24], cardiovascular disease [25],…”

Section: Discussionmentioning

confidence: 99%

Oral Microbiome Diversity Predicts All-cause Mortality in the General Population: A Prospective Population-based Cohort Study

Yang

et al. 2023

Preprint

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Background Increasing evidence suggests a potential link between oral microbiome diversity and the occurrence of multiple chronic extraoral diseases. However, evidence regarding oral microbiota diversity and long-term prognosis in the general population is limited. This prospective study aimed to investigate whether oral microbiome diversity is associated with all-cause mortality in the general population.Results During a mean follow-up period of 8.9 years, 429 deaths occurred. After multivariate adjustment, a negative association was observed between oral microbiome α diversity and all-cause mortality (P < 0.01). Significant differences in all-cause mortality risk were observed between the different clusters based on the oral microbiome β diversity (Log-rank P < 0.001). Subgroup analyses revealed that oral microbiome diversity was independently associated with all-cause mortality in individuals with extraoral diseases, particularly those with diabetes mellitus and hypertension. A multivariate logistic regression model demonstrated that increased dietary fiber intake and reduced antibiotic use were significantly associated with higher oral microbiome α diversity.Conclusions Higher oral microbiome diversity was significantly associated with a lower risk of all-cause mortality in the general population and in individuals with extraoral diseases, especially diabetes mellitus and hypertension. Reasonable restrictions on antibiotic use and high dietary fiber intake may increase oral microbiome diversity, thereby reducing the risk of all-cause mortality.

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Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Cited by 9 publications

References 68 publications

Altered gut mycobiome in patients with end-stage renal disease and its correlations with serum and fecal metabolomes

Altered gut mycobiome in patients with end-stage renal disease and its correlations with serum and fecal metabolomes

Gut microbiota’s causative relationship with peripheral artery disease: a Mendelian randomization study

Oral Microbiome Diversity Predicts All-cause Mortality in the General Population: A Prospective Population-based Cohort Study

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