Characteristics and Gender Differences Concerning Pulmonary Hemodynamics in Clawn Miniature Pigs

Abstract

Abstract:The characteristics and gender differences of the pulmonary hemodynamic parameters of 16 Clawn miniature pigs were examined and the data were compared with reports concerning dogs and other pig species. The pulmonary systolic, diastolic and mean arterial blood pressures of the mini-pig were slightly higher than those of the dog, respectively, but both the right atrial pressure and pulmonary capillary wedge pressure were within the normal physiological ranges of the dog. Concerning gender differences in hemodynamic parameters of the mini-pig, the female values, except the right atrial pressure, were slightly higher than those of the male, but no significant differences were recognized. The present study results will help pulmonary researchers understand the differences between Clawn miniature pigs and dogs for accurate analysis of experimental results.

Sex- and age-related differences in arterial pressure and albuminuria in mice

“…This was the case when Deschepper and colleagues [29] measured SAP (tail-cuff) in 13 strains of mice and discovered sex differences in only four strains; a sex difference in SAP was not detected in the FVB/N strain under baseline conditions contrary to our data. Additionally, a sex difference in SAP or DAP was not identified in 12-week-old rats [38], 3–4-month-old guinea pigs [39], or adult Clawn miniature pigs [40]. Nonetheless, it is important to recognize that failure to detect dimorphism in arterial pressure between the sexes most likely reflects the lack of statistical power and/or the low sensitivity of the method used to measure arterial pressure.…”