Characteristics and mortality of severe hyponatraemia – a hospital‐based study

Abstract

Severe hyponatraemia in hospital patients is associated with prolonged admissions and significantly increased mortality compared with normonatraemic patients. A particular group at high risk of death are those whose Na levels fall after admission. They may represent a 'sicker' group, and deserve increased monitoring and surveillance.

Rapid Correction Rate of Hyponatremia as an Independent Risk Factor for Neurological Complication Following Liver Transplantation

“…However, the significance of hyponatremia has been overlooked in clinical practice, and cases of mild chronic hyponatremia are generally considered benign (Decaux 2006). Recent studies have reported that hyponatremia is associated with a high mortality rate in various medical conditions (Baran and Hutchinson 1984;Tierney et al 1986;Gill et al 2006;Whelan et al 2009;Waikar et al 2009;Wald et al 2010). Hyponatremia is particularly prevalent in chronic liver disease and associated with a poor prognosis in patients with end stage liver disease waiting for a liver transplant (Angeli et al 2006;Kim et al 2008;Basto et al 2011).…”

Les troubles de l’équilibre hydrosodé chez les patients hospitalisés

“…6 A variety of risk factors have been reported for hospital-acquired hyponatremia, including older age, diabetes mellitus, chronic kidney disease, surgery, pulmonary infection, diuretic therapy, administration of antibiotics, opioid analgesia, and the use of hypotonic intravenous fluids. [7][8][9] It is important to recognize that hyponatremia, while frequent, is not a trivial diagnosis. It is associated with serious complications that have been linked to increased morbidity and mortality.…”

“…It is associated with serious complications that have been linked to increased morbidity and mortality. 1,8,[10][11][12][13] The presence of hyponatremia after an acute ST-elevation myocardial infarction in congestive heart failure and in patients with cirrhosis has been found to predict mortality. [10][11][12][13] Similarly, in critically ill patients, severe hyponatremia (serum [Na ? ]…”

“…\ 125 mmol l -1 ) has been shown to be an independent predictor of hospital mortality, with an estimated risk for death approaching 40%. 1 Gill et al 8 recently found that severe hyponatremia (serum [Na ? ] \ 125 mmol l -1 ) was associated with significantly higher mortality (27% vs. 9%, P = 0.009) and a longer duration of hospitalization (16 days vs. 13 days, P \ 0.005).…”

“…Moreover, mortality was reported higher for those patients whose hyponatremia initially worsened after hospital admission. 8 Clinical presentation of hyponatremia Symptoms attributable to hyponatremia correlate both with the severity and the rate of decline in serum [Na ? ] and generally reflect neurologic dysfunction induced by cerebral edema.…”