Characteristics and outcomes of health and social care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland

Siddiqui, Moneeza K; Parcell, Benjamin J.; Allstaff, Sarah; Palmer, Colin N.A.; Chalmers, James D.; Bell, Samira

doi:10.1183/13993003.02568-2020

Cited by 10 publications

(12 citation statements)

References 4 publications

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“…I read with interest the recently published report by Siddiqui and colleagues [ 1 ] which described the characteristics and outcomes of Health and Social Care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland.…”

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confidence: 99%

“…Health care workers (HCWs) are at risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection [ 1 , 2 ]. The best way for HCWs to prevent infection with SARS-CoV-2 is through training and demonstrated competency in putting on and removing, also known as donning and doffing, personal protective equipment (PPE) [ 3 ].…”

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confidence: 99%

“…In Mexico, 92% of affected HCWs had mild or moderate COVID-19, supporting the findings of Siddiqui et al . [ 1 ] The case fatality rate of COVID-19 in HCWs based on all cases reported by the Mexican Secretariat of Health was 1.48% (683/46 013) [ 6 , 7 ], as compared with an overall COVID-19 case fatality rate of 15.26% (25 096/162 379) (difference, 13,78%; 95% confidence interval: 13,57% to 13,98%; p<0.001).…”

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confidence: 99%

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Healthcare workers with COVID-19 in Mexico

Ñamendys‐Silva

2020

Eur Respir J

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confidence: 99%

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confidence: 99%

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Healthcare workers with COVID-19 in Mexico

Ñamendys‐Silva

2020

Eur Respir J

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“…It has been argued that healthcare workers are at increased risk of exposure to SARS-CoV-2 and potentially in uence in-hospital transmission [17,18]. As of August 25 in Mexico, there have been 568,621 con rmed COVID-19 cases and 61,450 associated deaths, and 97,632 health workers have been infected with SARS-CoV-2 (42% nurses, 27% medical staff, and 31% other health workers).…”

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confidence: 99%

SARS-CoV-2 Identification in Saliva: Are We Interpreting the Results Correctly?

Ramírez-Hinojosa

Rodríguez-Sánchez

Romero-Gonzalez

et al. 2020

Preprint

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BackgroundIn the present study, we obtained cycle threshold (Ct) values by qRT-PCR and compared them with clinical and laboratory data from saliva specimens of inpatients with COVID-19 and asymptomatic health workers (AHW).MethodsSaliva specimens from inpatients with COVID-19 and AHW were studied by qRT-PCR using three sets of primers for the N (N1, N2, and N3) gene of SARS-CoV-2. The Ct values obtained were compared with the clinical and laboratory data.ResultsData from 58 inpatients (37 critically ill patients and 21 patients with severe disease) and 105 AHW were analysed. In our system, the limit of viral detection corresponded to a Ct =46.5; therefore, our analysis focused on comparing the positivity rate obtained when using Ct <40 as the cut-off with that obtained using Ct <46 as the cut-off. The positivity rate was increased when the Ct cut-off of 46 was used as the criterion, yielding a sensitivity of 87.9% for patients and a sensitivity of 43% for AHW. The bivariate analysis revealed an association between Ct <40 for N2 and mechanical ventilation assistance among patients (p=0.013). In addition, the serological values of alanine transaminase (ALT), aspartate-transaminase (AST), lactate dehydrogenase (LDH), ferritin and creatine kinase–MB (CK-MB) showed significant correlations with the Ct values of N1 and N3.ConclusionDue to the intrinsic characteristics of the qRT-PCR process, obtaining amplification curves implies the presence of an active viral replication process, while Ct values may correlate with some clinical data. Our results support the claim that physicians should be informed of the Ct values obtained during the amplification of viral markers, as well as the Ct values that correspond to the limit of detection for viral RNA, which vary according to the characteristics of each system and amplification protocol used.

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“…Among the groups at greatest risk for acquiring COVID-19 infection are the health personnel, particularly doctors, 4 , 5 whose work in a precarious and fragmented health system puts them at a risk to fall ill and even lose their lives. 5 The best way for healthcare workers to prevent this infection is through the appropriate personal protective-equipment supply.…”

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confidence: 99%