Characteristics and outcomes of SARS-CoV-2 positivity in neonates born to mothers with COVID-19 in Klang Valley, Malaysia: a retrospective observational study

Lim, Sok Bee; See, Kwee Ching; Law, Kian Boon; Kamarudin, Nor Izwah Mohamed

doi:10.1016/j.ijregi.2022.10.001

Cited by 2 publications

(6 citation statements)

References 10 publications

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“…Exposure to infected mothers is an established risk factor [ 22 , 23 , 25 ]. This is especially true when the newborn–maternal contact occurs if the mother first becomes infected in the immediate postpartum phase [ 25 ].…”

Section: Covid-19 Among Infantsmentioning

confidence: 99%

“…Evidently, there is little clinical evidence to differentiate COVID-19 from other viral respiratory illnesses for all severities, and where any such differences may exist, the predictive values would be low. The frequency of infected newborns seen in prospective cohorts has been very low [ 22 , 25 , 54 - 57 ]. Among these studies, the number of those overtly symptomatic is another lower proportionate fraction.…”

Section: Covid-19 Among Infantsmentioning

confidence: 99%

“…Nosocomial transmission is accepted and includes infants as young as those in the early postpartum period. 2,8,11,[18][19][20][21][22][23][24] Some groups have experienced a paucity of such transmis-sions, but institutional outbreaks, including infants, have been cited. 2,19) Furthermore, there may be a very high rate of secondary infec tions in the outbreak setting affecting newborns, mothers, and healthcare workers.…”

Section: Role Of Contact Spreadmentioning

confidence: 99%

“…8) Exposure to infected mothers is an established risk factor. 22,23,25) This is especially true when the newborn-maternal contact occurs if the mother first becomes infected in the immediate postpartum phase. 25) Newborn in-rooming may be associated with a higher risk of infection, but no as sociation was found in feeding mode in one study.…”

Section: Role Of Contact Spreadmentioning

confidence: 99%

“…The frequency of infected newborns seen in prospective cohorts has been very low. 22,25,[54][55][56][57] Among these studies, the number of those overtly symptomatic is another lower proportionate fraction. Although this infrequency is rather consistent, some studies have not carefully considered the impact of the close timing of maternal infection on the delivery process.…”

Section: Manifestations Of Infant Infectionmentioning

confidence: 99%

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COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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Infants aged <1 year represent a seemingly more susceptible pediatric subset for infections. Despite this, coronavirus disease 2019 (COVID-19) infection has not been proven as more serious in this age group (outside the very early neonatal period) than in others. Indeed, a considerable number of asymptomatic infections have been recorded, and the symptoms and morbidity associated with COVID- 19 differ minimally from those of other respiratory viral infections. Whether due to an abundance of caution or truly reduced susceptibility, infections in infants have not raised the same profile as those in other age groups. In addition to direct severe acute respiratory syndrome coronavirus 2 diagnostic tests, laboratory markers that differentiate COVID-19 from other viral infections lack specificity in infants. Gastrointestinal presentations are common, and the neurological complications of infection mirror those of other respiratory viral infections. There have been relatively few reports of infant deaths. Under appropriate precautions, breastfeeding in the context of maternal infections has been associated with tangible but infrequent complications. Vaccination during pregnancy provides protection against infection in infants, at least in the early months of life. Multi-inflammatory syndrome in children and multi-inflammatory syndrome in neonates are commonly cited as variants of COVID-19; however, their clinical definitions remain controversial. Similarly, reliable definitions of long COVID in the infant group are controversial. This narrative review examines the key clinical and laboratory features of COVID-19 in infants and identifies several areas of science awaiting further clarification.

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Section: Covid-19 Among Infantsmentioning

confidence: 99%

Section: Covid-19 Among Infantsmentioning

confidence: 99%

Section: Role Of Contact Spreadmentioning

confidence: 99%

Section: Role Of Contact Spreadmentioning

confidence: 99%

Section: Manifestations Of Infant Infectionmentioning

confidence: 99%

See 3 more Smart Citations

COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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Vertical transmission of SARS-CoV-2 – data from the German COVID-19 related obstetric and neonatal outcome study (CRONOS)

Mand,

Rüdiger,

Hütten

et al. 2024

Journal of Perinatal Medicine

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Objectives We aimed to determine the frequency of SARS-CoV-2 positivity in newborns born to mothers with peripartum SARS-CoV-2 infection in a German cohort, to identify potential risk factors associated with neonatal SARS-CoV-2 infection, and to present short-term outcomes of newborns with vertical transmission of SARS-CoV-2. Methods Data on women with SARS-CoV-2 infection occurring anytime during their pregnancy was gathered prospectively within the CRONOS registry. From April 2020 to February 2023 a total of 8,540 women had been registered. The timing and the probability of mother-to-child transmission in neonates born to women with perinatal SARS-CoV-2 infection were classified using the WHO classification system. The severity of maternal infection, maternal vaccination status, type of dominant virus, and perinatal outcome parameters were analyzed as potential risk factors for neonatal SARS-CoV-2 infection. Results 6.3 % resp. 42.9 % of tested newborns and stillbirths were SARS-CoV-2 positive. 2.1 % of newborns with confirmed and possible SARS-CoV-2 infection were identified. Severe maternal COVID-19 (odds ratio 4.4, 95 % confidence interval 1.8–11.1) and maternal infection with the Delta virus (OR 3.2, 1.4–7.7) were associated with neonatal SARS-CoV-2 infection. Newborns with a confirmed or possible infection were significantly more often admitted to the NICU (65.2 % neonatal infection vs. 27.5 % non, p<0.001). Conclusions The rate of neonatal SARS-CoV-2 positivity was higher in our cohort than previously reported, neonatal SARS-CoV-2 infections were rare. Our data emphasizes confirmative testing should be performed in newborns of SARS-CoV-2 infected mothers to identify neonatal SARS-CoV-2 infection as an underlying pathology leading to NICU admission.

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Characteristics and outcomes of SARS-CoV-2 positivity in neonates born to mothers with COVID-19 in Klang Valley, Malaysia: a retrospective observational study

Cited by 2 publications

References 10 publications

COVID-19 among infants: key clinical features and remaining controversies

COVID-19 among infants: key clinical features and remaining controversies

Vertical transmission of SARS-CoV-2 – data from the German COVID-19 related obstetric and neonatal outcome study (CRONOS)

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