CHARACTERISTICS AND REGULATION OF BIOFILM FORMATION INSALMONELLA

Abstract

The ability to from biofilms, which is a common feature in Salmonella serovars, is the main cause of persistent infections and permanent contamination in both clinical and industrial systems. Because the biofilm structures are significantly more resistant to environmental stress conditions than the planktonic forms of bacteria, it is often impossible to remove them through conventional disinfection or sterilization practices. Therefore, it has become necessary to develop effective strategies in combating biofilms, which are defined as the dominant form of microbial life. To achieve this goal, it is necessary to understand the genetic regulatory mechanisms that control the transition from planktonic form to the biofilm form and the related changes in gene expression. In this review, the current state of knowledge regarding gene regulation systems that affect the biofilm formation in Salmonella, has been summarized and discussed.

Comparative Microbiota Analyses in Rats Administered S. Typhimurium 14028 and its dam and seqA Mutants

“…Here, too, the most critical point is to investigate Salmonella-gut microbiota relationships in all aspects (Burnett et Furthermore, obtained data indicating that activity of the Dam and SeqA in Salmonella plays a role in the regulation of various genes that govern many metabolic and physiological processes, including attachment to host target cells, colonization, cell invasion, systemic invasion, persistence, and bio lm formation. Besides, these genes have been placed in a key position in studies based on Salmonella pathogenicity and virulence with the increasing data (Giacomodonato et al 2004;Uğur et al 2018;Akçelik and Akçelik 2021). In this study, which is planned in line with all this literature information and experience, in addition to investigating the dysbiosis caused by the intestinal microbiota of rats infected with the Salmonella Typhimurium 14028 strain, which is known to form bio lm structures in adverse environmental conditions, and its dam and seqA mutants without bio lm-forming ability (determination of the change in healthy rat microbiota), the e ciency of the dam and seqA genes in the Salmonellamicrobiota connection is the goal of this study.…”