Characteristics and Risk Factors of Functional Dyspepsia Fulfilling the Rome IV Criteria Overlapping With Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China

Long, Yan-Qin; Xu, Wen-Li; Li, Lu-Xiu; He, Hui-Qin; Wang, Jing-Jie; Shan, Guo-Dong; Dai, Ning; Chen, Hong-Tan

doi:10.5056/jnm23084

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…The prevalence has been found to be 15.3% in studies that define FC according to Rome I criteria, 11.2% in studies using Rome II, 11.4% in studies using Rome III, and 10.1% in studies using Rome IV criteria (Barberio et al., 2021 ). FC has a negative impact on patients' quality of life and causes a significant financial burden (Abdullah et al., 2015 ; Long et al., 2023 ). Approximately 50% of patients with constipation are not completely satisfied with standard treatment (Johanson & Kralstein, 2007 ) due to lack of efficacy or safety concerns.…”

Section: Introductionmentioning

confidence: 99%

Xylo‐oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium

Yi,

Wang,

Xue

et al. 2023

Food Science & Nutrition

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Functional constipation (FC) has a negative impact on patients' quality of life. We hypothesized that dietary supplementation with xylo‐oligosaccharides (XOS) or fructo‐oligosaccharides (FOS) would improve constipation symptoms by influencing the gut microbiota. A randomized double‐blind controlled trial was conducted in FC patients. Patients were randomly divided into 6 groups and given a dietary supplement containing XOS at doses of 3, 5, or 10 g/day, FOS at doses of 10 and 20 g/day, or placebo at 5 g/day for one month. We compared improvements in gastrointestinal function after the intervention using the Bristol Stool Form Scale (BSFS), Cleveland Clinic Constipation Score (CCCS), and Quality of Life Scale for Patients with Constipation (PAC‐QoL). 16S rRNA sequencing was used to assess changes in the structure of the gut microbiota. Changes in individual bacteria had significant effects in reducing gastrointestinal symptoms during the intervention, even though the flora structure remained unchanged from baseline. Compared to FOS, XOS enriched Bifidobacterium at a lower dose, and patients receiving XOS supplementation showed significant improvements in constipation symptoms without side effects such as diarrhea and flatulence.

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Section: Introductionmentioning

confidence: 99%

Xylo‐oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium

Yi,

Wang,

Xue

et al. 2023

Food Science & Nutrition

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Efficacy and safety of Jiao Wei Xiao Shi decoction in patients with functional dyspepsia: A study protocol for a randomized controlled trial

Zhang,

Huang,

Yusup

et al. 2024

Preprint

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Background Functional dyspepsia (FD) is the most prevalent gastrointestinal disorder worldwide. Current medicine often faces limitations in the treatment of FD. Traditional Chinese medicine (TCM), with a history of thousands of years, offers a great contribution to Chinese people with FD. Jiao Wei Xiao Shi decoction (JWXSD) is a traditional Chinese medical prescription. However, the efficacy of JWXSD in FD is lacking. Therefore, this study will evaluate the efficacy and safety of JWXSD for the treatment of FD. Methods A randomized controlled trial will be conducted at Beijing University of Chinese Medicine. 72 participants with FD will be randomly allocated to three groups (JWXSD groups, Mosapride group and Placebogroup) at a ratio of 1:1:1. The primary outcome is Nepean Dyspepsia Symptom Index (NDSI). The secondary outcomes include the Nepean Dyspepsia Life Quality Index (NDLQI), Body Mass Index (BMI) and Pittsburgh Sleep Quality Index(PSQI). Primary and secondary outcomes will be evaluated at weeks 1, 3, 4, 8, 12 and 16. Adverse events will be assessed during the study. Discussion The outcomes from this trial will compare JWXSD, mosapride and placebo in FD participants. This study will provide clinical evidence that JWXSD can help to improve FD. Trial registration Chinese Clinical Trial Registry: ChiCTR2400082798. Registered on April 8, 2024.

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Dyspepsia in medical university students: prevalence of symptoms and risk factors

Paliy,

Zayika,

Chernova

et al. 2024

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Dyspepsia is one of the most common symptom complex encountered in internal medicine and includes a group of symptoms related to the gastroduodenal region of the gastrointestinal tract. The purpose of the research was to study the prevalence of dyspepsia symptoms among the 1-6 years students of National Pirogov Memorial Medical University, Vinnytsya, who did not seek medical help for symptoms of dyspepsia and also to establish risk factors for its development among the students in comparison with general practitioners. Using the Microsoft Forms platform we conducted a survey of 300 respondents aged 17-65, among them 168 (56%) were domestic students of the 1st-6th year of study, 64 (21,3%) were foreign students of the 5th-6th year of study, and 68 (22.7%) referred to the doctors of general practice. To assess the presence or absence of complaints from the respondents we used a modified FSSG (Frequency Scale for Symptoms of GERD) questionnaire supplemented with questions about the age, gender, body weight and height of the respondents, the course of study and academic success (applied to the students), the presence of chronic diseases of gastro-intestinal track, taking pharmaceutical drugs, smoking and alcohol consumption, indicating the number of doses per week. There was an additional question about native country in the questionnaire for foreign students. The arithmetic mean and standard error of the arithmetic mean were calculated. The statistical probability of the difference between two samples was calculated using the Student's t-test. We used the χ2 method to assess the influence of various factors on the occurrence of dyspepsia and GERD symptoms, and the correlation analysis was performed using the non-parametric Spearman method. It was found that in the group of domestic students, compared to foreign ones, there were significantly more (p<0.05) of those who noted the presence of dyspepsia symptoms (21.4% versus 10.9%), and significantly fewer (p<0.01) almost healthy (60.7% vs. 79.7%). Meanwhile, no significant differences were found between the groups of domestic students and the doctors of general practice, and between the groups of foreign students and the doctors (p>0.05). In all three groups we established a relationship between the presence of symptoms of dyspepsia and GERD and the presence of gastrointestinal diseases in the anamnesis of the respondents. Thus, the coefficient of Spearman’s ranks for the group of domestic students was 0.36, for the doctors group -0.43, and for foreign students group – 0.6 (p<0.01). In the groups of domestic students and foreign ones a correlation was established (p<0.01) between taking medication and the appearance of symptoms of dyspepsia and GERD. In particular, the Spearman rank coefficient for the group of domestic students was 0.2 and for the foreign students group – 0.42. At the same time, such a relationship was absent in the surveyed group of family medicine doctors (p>0.05). The coefficient of Spearman’s ranks for the doctors group was 0.43. The obtained results indicate that symptoms of dyspepsia, GERD and their combination were found in all examined groups. The presence of gastrointestinal pathology in the anamnesis is a risk factor for dyspepsia and GERD regardless of the respondents groups.

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Characteristics and Risk Factors of Functional Dyspepsia Fulfilling the Rome IV Criteria Overlapping With Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China

Cited by 3 publications

References 55 publications

Xylo‐oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium

Xylo‐oligosaccharides improve functional constipation by targeted enrichment of Bifidobacterium

Efficacy and safety of Jiao Wei Xiao Shi decoction in patients with functional dyspepsia: A study protocol for a randomized controlled trial

Dyspepsia in medical university students: prevalence of symptoms and risk factors

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