Characteristics and risk factors of lower urinary tract dysfunction in patients with Parkinson's disease: A systematic evaluation and meta-analysis

Zhang, Hongxia; Wang, Xueqi; Xu, Hao; Jing, Xiubing; Yue, Jiajia

doi:10.1016/j.clineuro.2021.106885

Cited by 4 publications

(2 citation statements)

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“…In the general population, two or more voids per night were considered to be bothersome, according to a survey involving 6000 participants [50]. A meta-analysis stated that seven factors are directly related to nocturia: disease duration, age, sleep impairments, constipation, H&Y scores >2, and higher scores on the UPDRS-III and MMSE evaluations [51]. The strong association between nocturia and sleep impairments may be explained by the delayed sleep re-onset after awakening during night due to the need to void [52].…”

Section: Discussionmentioning

confidence: 99%

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Nocturia and Sleep in Parkinson’s Disease

Diaconu

Irincu

Ungureanu

et al. 2023

JPM

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Background: Nocturia has a high prevalence in Parkinson’s Disease (PD) and is known to be a bothersome symptom for people with Parkinson’s disease (PwPD). Objective: to characterize nocturia in a sample of PwPD, in relation to sleep, fatigue and other non-motor symptoms (NMS). Methods: we assessed 130 PwPD using a comprehensive battery of scales, which includes the Non-Motor Symptoms Questionnaire (NMSQ), International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), Parkinson’s Disease Sleep Scale version 2 (PDSS-2), Parkinson’s Disease Questionnaire (PDQ-39), The Overactive Bladder Questionnaire-Short form (OABq-SF), and the Parkinson’s Fatigue Scale (PFS-16). Results: according to the positive answers to the item of the NMSQ related to nocturia, patients were divided into PwPD + nocturia, and PwPD − nocturia. Nocturia was reported by 112 patients (86.15%). Quality of life in PwPD + nocturia was worse than in PwPD − nocturia, according to the PDQ-39 scores (13.32 ± 9.00 vs. 26.29 ± 14.55, p < 0.001). Sleep was significantly disturbed in PwPD + nocturia compared to PwPD − nocturia, according to the total scores of various scales, such as PDSS-2, PFS-16. PwPD who complained of nocturia presented higher scores of several NMS. Conclusions: nocturia has a high prevalence in PwPD and it is associated with impaired sleep, fatigue, and reduced quality of life.

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Section: Discussionmentioning

confidence: 99%

“…Other non-motor domains that presented correlations with nocturia in our study were apathy, pain, and gastrointestinal domains. According to the results of the meta-analysis conducted by Zhuang et al, constipation represents a risk factor for dysfunction of the lower urinary tract [51].…”

Section: Discussionmentioning

confidence: 99%