Characteristics and Spontaneous Recovery of Tinnitus Related to Idiopathic Sudden Sensorineural Hearing Loss

Mühlmeier, G; Baguley, David; Cox, Tony; Suckfüll, M.; Meyer, Thomas

doi:10.1097/mao.0000000000001081

Cited by 44 publications

(49 citation statements)

References 23 publications

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“…Finally, a significant positive correlation was found between mean AT and THI as well as negative correlations between mean AT and mean SDS and between mean SDS and THI (Table 1). This confirms the association between loss of auditory input, tinnitus onset and speech discrimination impairment in the acute phase of the disease (Muhlmeier et al, 2016).…”

Section: Correlation Analysissupporting

confidence: 83%

Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss

et al. 2017

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Results in studies concerning cortical changes in idiopathic sudden sensorineural hearing loss (ISSNHL) are not homogeneous, in particular due to the different neuroimaging techniques implemented and the diverse stages of ISSNHL studied. Considering the recent advances in state-of-the-art positron emission tomography (PET) cameras, the aim of this study was to gain more insight into the neuroanatomical differences associated with the earliest stages of unilateral ISSNHL and clinical-perceptual performance changes. After an audiological examination including the mean auditory threshold (mean AT), mean speech discrimination score (mean SDS) and Tinnitus Handicap Inventory (THI), 14 right-handed ISSNHL patients underwent brain [F]fluorodeoxyglucose (FDG)-PET within 72 h of the onset of symptoms. When compared to an homogeneous group of 35 healthy subjects by means of statistical parametric mapping, a relative increase in FDG uptake was found in the right superior and medial frontal gyrus as well as in the right anterior cingulate cortex in ISSNHL patients. Conversely, the same group showed a significant relative decrease in FDG uptake in the right middle temporal, precentral and postcentral gyrus as well as in the left posterior cingulate cortex, left lingual, superior, middle temporal and middle frontal gyrus and in the left insula. Regression analysis showed a positive correlation between mean THI and glucose consumption in the right anterior cingulate cortex and a positive correlation between mean SDS and glucose consumption in the left precentral gyrus. The relative changes in FDG uptake found in these brain regions and the positive correlation with mean SDS and THI scores in ISSNHL could possibly highlight new aspects of cerebral rearrangement, contributing to further explain changes in those functions that support speech recognition during the sudden impairment of unilateral auditory input.

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Section: Correlation Analysissupporting

confidence: 83%

Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss

et al. 2017

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“…There exists a multitude of cross-sectional studies on factors associated with chronic tinnitus (e.g., this Frontiers Topic), whereas only few studies have attempted to assess participants with acute tinnitus ( 5 – 7 ) including a study that investigated tinnitus patients one year after their first visit to a clinic if they entered the clinic within 6 months of tinnitus onset ( 8 ). Therefore, time course as well as mechanisms involved in the transition from the acute to the chronic condition are unknown, and factors predisposing for the development of a chronic, disabling, or decompensated tinnitus are mostly inferred from retrospective reports.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, time course as well as mechanisms involved in the transition from the acute to the chronic condition are unknown, and factors predisposing for the development of a chronic, disabling, or decompensated tinnitus are mostly inferred from retrospective reports. Furthermore, studies on acute tinnitus usually were concerned with tinnitus following sudden HL ( 6 , 7 ) or acute acoustic trauma ( 9 ), which appear to be distinct as indicated by high remission rates which may reach 70% ( 10 ). High remission rates concomitant with an incidence of HL are likely related to partial recovery of hearing function in the first weeks after a temporary threshold shift ( 11 ), but not all patients can relate tinnitus onset to worsening of their hearing.…”

Section: Introductionmentioning

confidence: 99%

Transition from Acute to Chronic Tinnitus: Predictors for the Development of Chronic Distressing Tinnitus

et al. 2017

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BackgroundAcute tinnitus and its transition to chronic tinnitus are poorly investigated, and factors associated with amelioration versus exacerbation are largely unknown. Aims of this study were to identify early predictors for the future development of tinnitus severity.MethodPatients with tinnitus of no longer than 4 weeks presenting at an otolaryngologist filled out questionnaires at inclusion (T1), as well as 3 (T3), and 6 months (T4) after tinnitus onset. 6 weeks after onset, an interview was conducted over the phone (T2). An audiogram was taken at T1, perceived tinnitus loudness, and tinnitus-related distress were assessed separately and repeatedly together with oversensitivity to external sounds and the levels of depression and anxiety. Furthermore, coping strategies with illness were recorded.ResultsComplete remission until T4 was observed in 11% of the 47 participants, while voiced complaints at onset were stable in the majority. In the subgroup with a relevant level of depression at T1, tinnitus-related distress worsened in 30% until T4. For unilateral tinnitus, perceived loudness in the chronic condition correlated strongly with hearing loss at 2 kHz on the tinnitus ear, while a similar correlation was not found for tinnitus located to both ears or within the head.ConclusionResults suggest early manifestation of tinnitus complaints, and stress the importance of screening all patients presenting with acute tinnitus for levels of depression and tinnitus-related distress. Furthermore, hearing levels should be monitored, and use of hearing aids should be considered to reduce tinnitus loudness after having ascertained that sound sensitivity is within normal range.

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“…Previous studies have shown that the symptom of tinnitus decreased from 70% to 30% after 7 to 10 days SCT. In IT steroid procedure the improvement is much higher, ranging from 75% to 100% (Choi et al 2013;Hyun 2016;Mühlmeier et al 2016). In the current study, in terms of tinnitus, there was a significant improvement in 7 out of 8 patients.…”

Section: Discussionmentioning

confidence: 98%

Intratympanic Methylprednisolone Injection in Idiopathic Sudden Sensorineural Hearing Loss after Failure of Systemic Corticosteroid Therapy

Ho¹,

Idrus²,

Saim³

et al. 2018

JSM

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Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected cochlea. The objective of the current study was to evaluate the hearing outcomes of high dose IT methylprednisolone among ISSNHL patients after failure of systemic corticosteroid therapy (SCT). Hearing outcomes of SCT were evaluated over a 15 months period. Upon failure of SCT, the treatment was continued with higher dose IT steroid (methylprednisolone 62.5 mg/mL). Pre-treatment and post-treatment audiometric evaluations were analysed using pure tone audiogram (PTA). There were 36 patients diagnosed with ISSNHL included in the study. After two weeks of SCT, eighteen (56.3%) patients had hearing improvement of more than 10 dB. Another fourteen (43.7%) patients had no hearing improvement (less than 10 dB). Following that, twelve patients were recruited for weekly IT methylprednisolone for three weeks. During the one month follow up after completion of IT therapy, six patients (50%) showed more than 10 dB improvement in the PTA with a mean of 19.37 dB (p<0.05). Out of the six, two patients had more than 20 dB hearing improvement. Almost all patients in this study had an improvement in their symptoms of tinnitus and vertigo. High dose IT methylprednisolone after failure of SCT resulted in significant improvement in the patients' hearing outcome during one month follow up. The IT therapy not only improved the patients' hearing but in addition reduced the symptoms of tinnitus and vertigo.

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Characteristics and Spontaneous Recovery of Tinnitus Related to Idiopathic Sudden Sensorineural Hearing Loss

Cited by 44 publications

References 23 publications

Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss

Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss

Transition from Acute to Chronic Tinnitus: Predictors for the Development of Chronic Distressing Tinnitus

Intratympanic Methylprednisolone Injection in Idiopathic Sudden Sensorineural Hearing Loss after Failure of Systemic Corticosteroid Therapy

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